Effects of Cerebrospinal Fluid Drainage on Pro-Inflammatory and Anti-Inflammatory Cytokines Expression in the Subventricular Zone of Kaolin-Induced Hydrocephalic Rats
Muhammad Arifin Parenrengi,
Ahmad Data Dariansyah,
Wihasto Suryaningtyas
et al.
Abstract:Background: To determine the neuroprotective effect of CSF drainage by analyzing its impact on the expression and the ratio of pro-and anti-inflammatory cytokines in the subventricular zone in kaolininduced hydrocephalic rats. Method: Sprague-Dawley rats of 23 weeks of age (n=36) were used in this study. The rats were randomly divided into normal control, hydrocephalus, and CSF drainage-treated groups. Hydrocephalus was obtained by injecting 0,05 cc of 20% kaolin suspension into the cisterna magna. The CSF dra… Show more
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