Effects of centrophenoxine on body composition and some biochemical parameters of demented elderly people as revealed in a double-blind clinical trial

Fülöp, Tamás; Wórum, I; Csongor, J.; Leövey, A; Szabó, Tamás; Pék, Gy.; Zs.‐Nagy, Imre

doi:10.1016/0167-4943(90)90025-2

Cited by 8 publications

(2 citation statements)

References 15 publications

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“…A considerable rehydration of the intracellular mass was observed in the verum group at the expense of the extracellular liquid. Meanwhile, body weight remained unchanged 67. These data are mentioned here to demonstrate that nootropica, like CPH (and most probably also like BCE‐001), also behave in humans in the same predictable way as MHA.…”

Section: In Vivo Biological Effects Of Cph and Bce‐001supporting

confidence: 64%

Pharmacological Interventions against Aging through the Cell Plasma Membrane

Zs.‐Nagy

2002

Annals of the New York Academy of Sciences

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As was shown in a recent review by this author (Ann. N.Y. Acad. Sci., 928: 187-199, 2001), oxyradicals cannot be considered only as harmful by-products of the oxidative metabolism, but living cells and organisms implicitly require their production. This idea is supported by numerous facts and arguments, the most important of which is that the complete inhibition of the oxyradical production by KCN (or by any block of respiration) kills the living organisms long before the energy reserves would be exhausted. This new theoretical approach not only helps our understanding of the normal functions of the living organisms, such as the basic memory mechanisms in the brain cells, but also helps in identifying the site-specific, radical-induced damaging mechanisms that represent the undesirable side effects of oxygen free radicals. First of all, these effects make the cell plasma membrane vulnerable and cause a series of intracellular functional disorders, as described by the membrane hypothesis of aging (MHA). The logical way for any antiaging intervention therefore should be to increase the available number of loosely bound electrons inside the plasma membrane that are easily accessible for OH(*) free radical scavenging. The present review summarizes the available knowledge regarding the theory of the use of membrane-related antiaging pharmaca, like centrophenoxine (CPH), tested in both animal experiments and human clinical trials. A modified, developed version of CPH coded as BCE-001 is also reported.

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Section: In Vivo Biological Effects Of Cph and Bce‐001supporting

confidence: 64%

Pharmacological Interventions against Aging through the Cell Plasma Membrane

Zs.‐Nagy

2002

Annals of the New York Academy of Sciences

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“…CPH treatment of 8 weeks improved the psychometric and behavioral performance in about 50% of patients with medium-level dementia. The placebo group displayed improvement only in 27% [99]. A considerable rehydration of the intracellular mass was observed in the verum group at the expense of the extracellular liquid, while the body weight remained unchanged.…”

Section: Human Experiments With Centrophenoxinementioning

confidence: 78%

Aging of Cell Membranes: Facts and Theories

Zs-Nagy

2014

Interdisciplinary Topics in Gerontology and Geriatrics

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This chapter is intended to outline the main results of a research trend realized by the author during the last 45 years, focused on the main role played by the cell membrane in the aging process. It is a very wide field; therefore, the reader cannot expect in this limited space a detailed description, but will be given a wide, interdisciplinary insight into the main facts and theories regarding cellular aging. The central idea described here is the concept called the membrane hypothesis of aging (MHA). The history, the chemical roots, physicochemical facts, biophysical processes, as well as the obligatory biochemical consequences are all touched in by indicating the most important sources of detailed knowledge for those who are more interested in the basic biology of the aging process. This chapter covers also the available anti-aging interventions on the cell membrane by means of the centrophenoxine treatment based on the MHA. It also briefly interprets the possibilities of a just developing anti-aging method by using the recombinant human growth hormone, essential basis of which is the species specificity, and the general presence of receptors of this hormone in the plasma membrane of all types of cells.

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Risk Associated with the Use of Selected Ingredients in Food Supplements

Jędrejko

Lazur

Muszyńska

2021

Chemistry & Biodiversity

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This review focuses on four new product categories of food supplements: pre‐workout, fat burner/thermogenic, brain/cognitive booster, and hormone/testosterone booster. Many food supplements have been shown to be contaminated with unauthorized substances. In some cases, the ingredients in the new categories of dietary supplements were medicinal products or new synthetic compounds added without performing clinical trials. Some of the new ingredients in dietary supplements are plant materials that are registered in the pharmacopoeia as herbal medicines. In other cases, dietary supplements may contain plant materials that have no history of human use and are often used as materials to ‘camouflage’ stimulants. In the European Union, new ingredients of dietary supplements, according to European Food Safety Authority or unauthorized novel food. Furthermore, selected ingredients in dietary supplements may be prohibited in sports and are recognized as doping agents by World Anti‐Doping Agency.

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Effects of centrophenoxine on body composition and some biochemical parameters of demented elderly people as revealed in a double-blind clinical trial

Cited by 8 publications

References 15 publications

Pharmacological Interventions against Aging through the Cell Plasma Membrane

Pharmacological Interventions against Aging through the Cell Plasma Membrane

Aging of Cell Membranes: Facts and Theories

Risk Associated with the Use of Selected Ingredients in Food Supplements

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