Effects of central irisin administration on the uncoupling proteins in rat brain

Erden, Yavuz; Tekin, Suat; Sandal, Süleyman; Önalan, Ebru Etem; Tektemur, Ahmet; Kırbağ, Sevda

doi:10.1016/j.neulet.2016.02.046

Cited by 32 publications

(14 citation statements)

References 68 publications

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“…Inhibiting ROS formation may be a potential strategy for the treatment of I/R‐induced AKI. Irisin, although discovered as a metabolic regulator, has been found to improve mitochondrial function and reduce ROS formation (Askari et al, 2018; Batirel, Bozaykut, Mutlu Altundag, Kartal Ozer, & Mantzoros, 2014; Bi et al, 2020; Bi, Zhang, Ren, Du, Li, Wang, Wei, et al, 2019; Bi, Zhang, Ren, Du, Li, Wang, Zhang, et al, 2019; Butt, Hackett, & Volkoff, 2017; Chen et al, 2017; de Oliveira Bristot, de Bem Alves, Cardoso, da Luz Scheffer, & Aguiar, 2019; Deng et al, 2018; Erden et al, 2016; J. Fan, Zhu, et al, 2019; Mazur‐Bialy, Kozlowska, Pochec, Bilski, & Brzozowski, 2018; Ren et al, 2019, 2020; Tan, Ouyang, Xiao, Zhong, & Dong, 2019; Z. Wang, Chen, et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Involvement of GPX4 in irisin's protection against ischemia reperfusion‐induced acute kidney injury

Zhang

Ren

et al. 2020

Journal Cellular Physiology

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Ischemia reperfusion (I/R)-induced acute kidney injury (AKI) is a common and serious condition. Irisin, an exercise-induced hormone, improves mitochondrial function and reduces reactive oxygen species (ROS) production. Glutathione peroxidase 4 (GPX4) is a key regulator of ferroptosis and its inactivation aggravates renal I/R injury by inducing ROS production. However, the effect of irisin on GPX4 and I/Rinduced AKI is still unknown. To study this, male adult mice were subjected to renal I/R by occluding bilateral renal hilum for 30 min, which was followed by 24 hr reperfusion. Our results showed serum irisin levels were decreased in renal I/R mice. Irisin (250 μg/kg) treatment alleviated renal injury, downregulated inflammatory response, improved mitochondrial function, and reduced ER stress and oxidative stress after renal I/R, which were associated with upregulation of GPX4. Treated with RSL3 (a GPX4 inhibitor) abolished irisin's protective effect. Thus, irisin attenuates I/R-induced AKI through upregulating GPX4.

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Section: Discussionmentioning

confidence: 99%

Involvement of GPX4 in irisin's protection against ischemia reperfusion‐induced acute kidney injury

Zhang

Ren

et al. 2020

Journal Cellular Physiology

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“…Also, in brain ischemia state, the researchers observed that marked increased levels of ROS and malondialdehyde were reduced by irisin treatment in peri-infarct brain tissues [ 130 ]. Furthermore, uncoupling proteins, as a regulator in mitochondrial biogenesis and neuroprotection and synaptic function in the CNS, was increased by high dose administration of irisin in all brain areas [ 131 , 132 , 133 ]. Given these clinical application of irisin, we speculate that irisin may contribute to the improvement of neuropathy by reducing neuroinflammation, and enhancing synaptic functions in AD brain.…”

Section: Discussionmentioning

confidence: 99%

The Role of Irisin in Alzheimer’s Disease

Kim

Song

2018

JCM

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Alzheimer’s disease (AD) is characterized by progressive memory dysfunction, oxidative stress, and presence of senile plaques formed by amyloid beta (Aβ) accumulation in the brain. AD is one of the most important causes of morbidity and mortality worldwide. AD has a variety of risk factors, including environmental factors, metabolic dysfunction, and genetic background. Recent research has highlighted the relationship between AD and systemic metabolic changes such as glucose and lipid imbalance and insulin resistance. Irisin, a myokine closely linked to exercise, has been associated with glucose metabolism, insulin sensitivity, and fat browning. Recent studies have suggested that irisin is involved in the process in central nervous system (CNS) such as neurogenesis and has reported the effects of irisin on AD as one of the neurodegenerative disease. Here, we review the roles of irisin with respect to AD and suggest that irisin highlight therapeutic important roles in AD. Thus, we propose that irisin could be a potential future target for ameliorating AD pathology and preventing AD onset.

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“…Irisin was shown to influence UCP2 expression depending on time of exposure. Indeed, acute central irisin administration was found to decrease UCP2 mRNA expression in the rat hypothalamus, while opposite effects were observed following long‐term intracerebroventricular infusion of irisin . Irisin was also found to increase the expression of brain‐derived neurotrophic factor (BDNF), a neurotrophin that regulates neuronal activity and survival, as well as neurogenesis and synapse formation and may improve cognitive function …”

Section: Introductionmentioning

confidence: 99%

Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain

Natalicchio

Marrano

Biondi

et al. 2019

Diabetes Metabolism Res

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Background Irisin, a newly discovered muscle‐derived hormone, acts in different organs and tissues, improving energy homeostasis. In this study, we assessed, for the first time, the effects of intraperitoneal irisin injections on circulating levels of leptin and ghrelin, mRNA expression of the major hypothalamic appetite regulators and brain neurotrophic factors, as well as feeding behaviour in healthy mice. Methods Twelve male 6‐week‐old C57BL/6 mice were randomized into two groups and intraperitoneally injected daily with irisin (0.5 μg/g body weight) or vehicle (phosphate‐buffered saline [PBS]) for 14 days. On the last day of observation, leptin and ghrelin levels were measured with an enzyme‐linked immunosorbent assay (ELISA). mRNA levels of genes of interest were analysed by quantitative reverse transcription polymerase chain reaction (qRT‐PCR) in brain extracts. Results Irisin administration did not change leptin or ghrelin serum concentrations. However, irisin injection increased CART, POMC, NPY, and BDNF mRNA levels, without affecting the mRNA expression of AgRP, orexin, PMCH, and UCP2. Finally, over the time frame of irisin treatment, body weight and feeding behaviour were unaltered. Conclusions These results suggest that intraperitoneal injection of irisin, although without effects on feeding behaviour and body weight, can increase the expression of anorexigenic and neurotrophic genes in mouse brain.

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Effects of central irisin administration on the uncoupling proteins in rat brain

Cited by 32 publications

References 68 publications

Involvement of GPX4 in irisin's protection against ischemia reperfusion‐induced acute kidney injury

Involvement of GPX4 in irisin's protection against ischemia reperfusion‐induced acute kidney injury

The Role of Irisin in Alzheimer’s Disease

Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain

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