Effects of centipedic acid on acute lung injury: A dose-response study in a murine model

Gondim, Fladimir de Lima; Moura, Marcelle Ferreira; Sousa, Allison Matias de; Ferreira, Ruth Mesquita; Serra, Daniel Silveira; Lima, Mary Anne Sousa; Pimenta, Antônia Torres Ávila; Zin, Walter A.; Cavalcante, Francisco Sales Ávila

doi:10.1016/j.resp.2022.103988

Respiratory Physiology & Neurobiology

2023

DOI: 10.1016/j.resp.2022.103988

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Effects of centipedic acid on acute lung injury: A dose-response study in a murine model

Fladimir de Lima Gondim

Marcelle Ferreira Moura

Allison Matias de Sousa

et al.

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2023

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FIXED OIL DERIVED FROM Caryocar coriaceum (PEQUI FRUIT) PREVENTS TISSUE AND FUNCTIONAL ALTERATIONS IN THE RESPIRATORY SYSTEM INDUCED HOUSEHOLD AIR POLLUTION ORIGINATING FROM BIOMASS

Sousa,

Gondim,

Santos

et al. 2023

Environ. Smoke

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The reuse of biomass residue can be in different ways, such as pellets obtained through the compaction of green coconut shell. Despite the advantages, studies relate the burning of biomass as the main source of household air pollution. Indoor pollution is also correlated with serious consequences for groups considered at risk, such as asthmatics. As a result, the population is looking for alternative and low-cost treatments through natural products with anti-inflammatory characteristics, such as the fixed oil of Caryocar coriaceum (CC). In the present study, we evaluated the effects of oral CC ingestion on the respiratory system of mice submitted to a model of chronic exposure to smoke from the combustion of coconut shell pellets (CSP) and submitted to the OVA-induced asthma model. We performed analysis of the gaseous composition in the exposure chamber and analyzes of different aspects of the respiratory system. CC could prevent inflammatory cell infiltration and alveolar collapse. Furthermore, it was able to avoid changes in the airway resistance, tissue resistance, elastance, compliance and inspiratory capacity. Our findings demonstrate the effects of long-term exposure to indoor pollution and suggest that dietary intake of CC may be a strategy to prevent respiratory diseases.

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FIXED OIL DERIVED FROM Caryocar coriaceum (PEQUI FRUIT) PREVENTS TISSUE AND FUNCTIONAL ALTERATIONS IN THE RESPIRATORY SYSTEM INDUCED HOUSEHOLD AIR POLLUTION ORIGINATING FROM BIOMASS

Sousa,

Gondim,

Santos

et al. 2023

Environ. Smoke

Self Cite

View full text Add to dashboard Cite

show abstract

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Effects of centipedic acid on acute lung injury: A dose-response study in a murine model

Cited by 1 publication

References 35 publications

FIXED OIL DERIVED FROM Caryocar coriaceum (PEQUI FRUIT) PREVENTS TISSUE AND FUNCTIONAL ALTERATIONS IN THE RESPIRATORY SYSTEM INDUCED HOUSEHOLD AIR POLLUTION ORIGINATING FROM BIOMASS

FIXED OIL DERIVED FROM Caryocar coriaceum (PEQUI FRUIT) PREVENTS TISSUE AND FUNCTIONAL ALTERATIONS IN THE RESPIRATORY SYSTEM INDUCED HOUSEHOLD AIR POLLUTION ORIGINATING FROM BIOMASS

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