Effects of celiac superior mesenteric ganglionectomy on glucose homeostasis and hormonal changes during oral glucose tolerance testing in rats

Abstract

The liver plays an important role in the maintenance of whole-body glucose homeostasis. In the prandial state, some of the glucose which is absorbed by the gastrointestinal tract is converted into glycogen and stored in the liver. In contrast, the liver produces glucose by glycogenolysis and gluconeogenesis while fasting. Thus, the liver contributes to maintaining blood glucose level within normoglycemic range. Magnusson et al. using the 13 C-nuclear magnetic resonance system [1, 2] observed that both hepatic glycogenolysis and

Laparoscopic treatment of median arcuate ligament syndrome without ganglionectomy of the celiac plexus in the hybrid operating room: Report of a case

“…In animal experimental study about the pathogenesis of acute cholecystitis, ganglionectomy of the celiac plexus alone did not induce acute cholecystitis, but it played an important role in the progression of the inflammatory process in ischemia-reperfusion injury [ 12 ]. In another animal experiment, it was reported that the celiac plexus regulated hepatic glucose metabolism and was a critical component in the maintenance of blood glucose homeostasis [ 13 ]. Based on these reports, surgical indication of ganglionectomy of the celiac plexus in MALS patients should be considered carefully.…”

Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans

“…After oral glucose loading, blood levels of secretory factors other than insulin, such as gut-derived incretins, and activity of sympathetic nerve system fluctuate dramatically in humans. 16,17,20) Further cellular or animal studies are needed to determine whether incretins and sympathetic nerve system regulate circulating levels of SeP during OGTT.…”

Interventional metabology: A review of bariatric arterial embolization and endovascular denervation for treating metabolic disorders

“…Early research demonstrated that celiac ganglionectomy improved glucose tolerance in rats, 58 and surgical or chemical sympathetic denervation of the common hepatic artery improves glucose tolerance and postprandial glucose clearance 59 . Hurr et al 60 showed that liver sympathetic nerve activity increased in the obese mice, and hepatic steatosis was alleviated by sympathetic denervation.…”