Effects of celecoxib on volumes of hematoma and edema in patients with primary intracerebral hemorrhage

Park, Hee-Kwon; Lee, Seung‐Hoon; Chu, Kon; Roh, Jae-Kyu

doi:10.1016/j.jns.2008.12.020

Cited by 35 publications

(17 citation statements)

References 29 publications

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“…47 A small, retrospective study investigated the efficacy/ safety of the cyclooxygenase-2 inhibitor celecoxib, in patients with ICH compared with a similar control group and reported a significant reduction in edema volume on follow-up imaging. 48 The 49 DFO was well tolerated, and not associated with an increase in serious adverse effects or mortality. Phase 2 evaluation of DFO is currently underway.…”

Section: Pharmacological Manipulation Of Inflammation and Oxidative Smentioning

confidence: 91%

Hematology and Inflammatory Signaling of Intracerebral Hemorrhage

Ziai

2013

Stroke

129

120

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Section: Pharmacological Manipulation Of Inflammation and Oxidative Smentioning

confidence: 91%

Hematology and Inflammatory Signaling of Intracerebral Hemorrhage

Ziai

2013

Stroke

129

120

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“…23,59 One retrospective study analyzed the volumes of hematoma and edema in 17 patients treated with celecoxib. 93 Treatment significantly reduced the volume of brain edema and the ratio of initial hematoma and edema volumes to follow-up volumes compared with the control group. The results of a Phase II trial investigating the efficacy of celecoxib are currently pending.…”

mentioning

confidence: 83%

Thrombin and hemin as central factors in the mechanisms of intracerebral hemorrhage–induced secondary brain injury and as potential targets for intervention

Babu¹,

Bagley²,

Di³

et al. 2012

FOC

165

138

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Intracerebral hemorrhage (ICH) is a subtype of stoke that may cause significant morbidity and mortality. Brain injury due to ICH initially occurs within the first few hours as a result of mass effect due to hematoma formation. However, there is increasing interest in the mechanisms of secondary brain injury as many patients continue to deteriorate clinically despite no signs of rehemorrhage or hematoma expansion. This continued insult after primary hemorrhage is believed to be mediated by the cytotoxic, excitotoxic, oxidative, and inflammatory effects of intraparenchymal blood. The main factors responsible for this injury are thrombin and erythrocyte contents such as hemoglobin. Therapies including thrombin inhibitors, N-methyl-D-aspartate antagonists, chelators to bind free iron, and antiinflammatory drugs are currently under investigation for reducing this secondary brain injury. This review will discuss the molecular mechanisms of brain injury as a result of intraparenchymal blood, potential targets for therapeutic intervention, and treatment strategies currently in development.

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“…There was no difference in the number of adverse events between the 2 groups. These results suggested that celecoxib may be safe and efficacious in patients with primary ICH [106].…”

Section: Edema: Celecoxibmentioning

confidence: 74%

Treatment Targets in Intracerebral Hemorrhage

Sangha

Gonzales

2011

Neurotherapeutics

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Intracerebral hemorrhage (ICH) imparts a higher mortality and morbidity than ischemic stroke. The therapeutic interventions that are currently available focus mainly on supportive care and secondary prevention. There is a paucity of evidence to support any one acute intervention that improves functional outcome. This chapter highlights current treatment targets for ICH based on the pathophysiology of the disease.

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Effects of celecoxib on volumes of hematoma and edema in patients with primary intracerebral hemorrhage

Cited by 35 publications

References 29 publications

Hematology and Inflammatory Signaling of Intracerebral Hemorrhage

Hematology and Inflammatory Signaling of Intracerebral Hemorrhage

Thrombin and hemin as central factors in the mechanisms of intracerebral hemorrhage–induced secondary brain injury and as potential targets for intervention

Treatment Targets in Intracerebral Hemorrhage

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