Effects of Cedrus atlantica extract on acute myeloid leukemia cell cycle distribution and apoptosis

Hung, Pei‐Hsiu; Hsieh, Ming‐Chang; Lee, Shan-Chih; Huang, Xiao‐Fan; Chang, Kai‐Fu; Chen, Szu-Yin; Lee, Ming-Shih; Tsai, Nu‐Man

doi:10.1007/s11033-020-05947-w

Cited by 7 publications

(2 citation statements)

References 36 publications

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“…Atlantic cedar ( Cedar atlantica ) is characterized by wide biological activity, including anti-inflammatory [ 19 ], anticancer [ 20 , 21 ], antioxidant [ 22 ], antimicrobial [ 23 ], and insecticidal [ 24 ] activities. An analgesic effect has also been described [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Antioxidant, In Vitro and In Situ Antimicrobial, Antibiofilm, and Anti-Insect Activity of Cedar atlantica Essential Oil

Kačániová

Galovičová

Valková

et al. 2022

Plants

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The present study was designed to evaluate commercial cedar essential oil (CEO), obtained by hydrodistillation from cedar wood, in relationship to its chemical composition and antioxidant, in vitro and in situ antimicrobial, antibiofilm, and anti-insect activity. For these purposes, gas chromatography–mass spectrometry, DPPH radical-scavenging assay, agar and disc diffusion, and vapor phase methods were used. The results from the volatile profile determination showed that δ-cadinene (36.3%), (Z)-β-farnesene (13.8%), viridiflorol (7.3%), and himachala-2,4-diene (5.4%) were the major components of the EO chemical constitution. Based on the obtained results, a strong antioxidant effect (81.1%) of the CEO was found. CEO is characterized by diversified antimicrobial activity, and the zones of inhibition ranged from 7.33 to 21.36 mm in gram-positive and gram-negative bacteria, and from 5.44 to 13.67 mm in yeasts and fungi. The lowest values of minimal inhibition concentration (MIC) were noted against gram-positive Micrococcus luteus (7.46 µL/mL) and against yeast Candida krusei (9.46 µL/mL). It seems that the vapor phase of CEO can inhibit the growth of the microscopic filamentous fungi of the genus Penicillium according to in situ antifungal analysis on bread, carrots, and celery. This finding confirms the impact of CEO on the change in the protein structure of older biofilms of Pseudomonas fluorescens and Salmonella enterica subsp. enterica. Insecticidal activity of a vapor phase has also been demonstrated against Pyrrhocoris apterus. CEO showed various advantages on antimicrobial activity, and it is an ideal substitute for food safety.

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Section: Introductionmentioning

confidence: 99%

Chemical Composition, Antioxidant, In Vitro and In Situ Antimicrobial, Antibiofilm, and Anti-Insect Activity of Cedar atlantica Essential Oil

Kačániová

Galovičová

Valková

et al. 2022

Plants

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“…Each year, between 80,000 and 100,000 m 3 of logs are used for veneering and sawing, constituting approximately 90% of the country’s total production (HCEFLCD 2013) . Cedarwood essential oils (EOs) have also shown promising biological activities, including antioxidant, − antimicrobial, , antifungal, , antiviral, anti-inflammatory, , analgesic, , anticancer, − and insecticidal , properties. Furthermore, these EOs are used in perfumes and cosmetics due to the presence of hemachalenes .…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Hydrodistillation of Healthy Cedrus atlantica Manetti and Infected by Trametes pini and Ungulina officinalis: Effect on Antibacterial Activity Utilizing a Mixture-Design Method

Moustaid,

Saffaj,

Annemer

et al. 2023

ACS Omega

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The Atlas cedar belongs to the Pinaceae family of trees and can be found in a crucial resinous mountain forest in Morocco that spans 133,000 hectares. This endemic species is valued for its wood quality and essential oil (EO), which has various biological activities. However, pathogenic fungi, particularly Trametes pini and Ungulina officinalis , frequently attack Atlas cedarwood, causing significant damage and loss of value. This study aims to extract EO from both healthy and infected Atlas cedarwood to promote its valorization and to assess the antibacterial properties of the resulting EOs. The EOs from healthy and sick cedarwood, as well as a combination of these woods, were extracted using hydrodistillation and simultaneous hydrodistillation. Gas chromatography and mass spectrometry were used to examine the chemical compositions of the EOs. In addition, the disk diffusion method and a measurement of the minimum inhibitory concentration were used to assess the EOs’ antibacterial activity against two bacterial strains, namely, Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). The results show that the extraction yields of healthy cedarwood, cedarwood infected by Trametes pini , and cedarwood infected by U. officinalis were 1.43 ± 0.03, 0.56 ± 0.03, and 0.26 ± 0.06%, respectively, Moreover, the antibacterial results showed that neither the healthy nor the diseased cedar oil had any impact on either strain. However, the EOs from some binary mixtures (75:25, 50:50, and 25:75%) of cedarwood infected by Trametes pini and cedarwood infected by U.ngulina officinalis and the mixture of healthy cedarwood and cedarwood infected by the two fungi inhibited the growth of S. aureus with different MIC values. The findings of this research could lead to the development of new products with antibacterial properties, such as natural disinfectants, and reduce the amount of waste generated by the cedar industry.

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Latex C-serum from Hevea brasiliensis induces apoptotic cell death in a leukemic cell line

Buncherd¹,

Hongmanee²,

Saechan³

et al. 2023

Mol Biol Rep

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Effects of Cedrus atlantica extract on acute myeloid leukemia cell cycle distribution and apoptosis

Cited by 7 publications

References 36 publications

Chemical Composition, Antioxidant, In Vitro and In Situ Antimicrobial, Antibiofilm, and Anti-Insect Activity of Cedar atlantica Essential Oil

Chemical Composition, Antioxidant, In Vitro and In Situ Antimicrobial, Antibiofilm, and Anti-Insect Activity of Cedar atlantica Essential Oil

Simultaneous Hydrodistillation of Healthy Cedrus atlantica Manetti and Infected by Trametes pini and Ungulina officinalis: Effect on Antibacterial Activity Utilizing a Mixture-Design Method

Latex C-serum from Hevea brasiliensis induces apoptotic cell death in a leukemic cell line

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