Effects of caudate lesions on the acquisition and retention of Sidman avoidance in the rat

Allen, Joseph D.; Mitcham, Judson C.; Byrd, James I.

doi:10.3758/bf03328923

Cited by 13 publications

(8 citation statements)

References 11 publications

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“…The 2-DG autoradiograph revealed that, in adult Paired rats, the medial part of the posterior striatum showed an increased activity compared to Unpaired and Odor animals. A growing literature suggests the involvement of the striatum in interval timing (Allen et al, 1972 ; Hikosaka et al, 1989 ; Matell et al, 2003 ; Höhn et al, 2011 ). According to McGeorge and Faull ( 1989 ), the lateral dorsal striatum receives projections from the sensori-motor cortex, while the medial posterior dorsal striatum receives inputs from the piriform cortex (McGeorge and Faull, 1989 ) and the amygdala (McDonald, 1991 ).…”

Section: Discussionmentioning

confidence: 99%

Infant rats can learn time intervals before the maturation of the striatum: evidence from odor fear conditioning

Boulanger-Bertolus

Hegoburu

Ahers

et al. 2014

Front. Behav. Neurosci.

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Interval timing refers to the ability to perceive, estimate and discriminate durations in the range of seconds to minutes. Very little is currently known about the ontogeny of interval timing throughout development. On the other hand, even though the neural circuit sustaining interval timing is a matter of debate, the striatum has been suggested to be an important component of the system and its maturation occurs around the third post-natal (PN) week in rats. The global aim of the present study was to investigate interval timing abilities at an age for which striatum is not yet mature. We used odor fear conditioning, as it can be applied to very young animals. In odor fear conditioning, an odor is presented to the animal and a mild footshock is delivered after a fixed interval. Adult rats have been shown to learn the temporal relationships between the odor and the shock after a few associations. The first aim of the present study was to assess the activity of the striatum during odor fear conditioning using 2-Deoxyglucose autoradiography during development in rats. The data showed that although fear learning was displayed at all tested ages, activation of the striatum was observed in adults but not in juvenile animals. Next, we assessed the presence of evidence of interval timing in ages before and after the inclusion of the striatum into the fear conditioning circuit. We used an experimental setup allowing the simultaneous recording of freezing and respiration that have been demonstrated to be sensitive to interval timing in adult rats. This enabled the detection of duration-related temporal patterns for freezing and/or respiration curves in infants as young as 12 days PN during odor fear conditioning. This suggests that infants are able to encode time durations as well as and as quickly as adults while their striatum is not yet functional. Alternative networks possibly sustaining interval timing in infant rats are discussed.

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Section: Discussionmentioning

confidence: 99%

Infant rats can learn time intervals before the maturation of the striatum: evidence from odor fear conditioning

Boulanger-Bertolus

Hegoburu

Ahers

et al. 2014

Front. Behav. Neurosci.

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show abstract

“…This general interpretation may also account for caudateinduced deficits that have been observed in several other tasks, including various avoidance paradigms (Neil1 and Crossman, 1971;Allen et al, 1972;Mitcham and Thomas, 1972;Allen and Davison, 1973;Winocur, 1974;Prado-Acala et al, 1975) cued Morris water maze performances (Whishaw and Kolb, 1984;Whishaw et al, 1987), brightness discrimination (Schwartzbaum and Donovick, 1968) right-left maze discrimination (Cook and Kesner, 1984) and visual/olfactory conditioned emotional responding (Viaud and White, 1989).…”

Section: Discussion Of Experimentsmentioning

confidence: 99%

Differential effects of fornix and caudate nucleus lesions on two radial maze tasks: evidence for multiple memory systems

1989

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The present experiments were designed to examine the hypothesis that the mammalian brain contains anatomically distinct memory systems. Rats with bilateral lesions of caudate nucleus or fimbria-fornix and a control group were tested postoperatively on 1 of 2 versions of the radial maze task. In a standard win-shift version, each of the 8 arms of the maze was baited once, and the number of errors (revisits) in the first 8 choices of each trial was recorded. Fimbria-fornix rats were impaired in choice accuracy, while caudate animals were unimpaired relative to controls. Different groups of rats with similar lesions were tested on a newly developed win-stay version of the radial maze, in which the location of 4 randomly selected baited arms was signaled by a light at the entrance to each arm, and which required rats to revisit arms in which reinforcement had been previously acquired within a trial. Rats with fimbria-fornix lesions were superior to controls in choice accuracy on the win-stay radial maze task, while caudate animals were impaired relative to controls. The results demonstrate a double dissociation of the mnemonic functions of the hippocampus and caudate nucleus. Some implications of the presence of 2 memory systems in the mammalian brain are discussed.

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“…Rats with dorsal striatum lesions are also impaired on various tasks involving escape and avoidance responses. Green, Beatty, and Schwartzbaum (1967) showed that dorsal striatum lesions impair acquisition of a two-chamber active avoidance response, and there are numerous other reports of similar effects (Allen & Mitcham, 1972;Green et al, 1967;Neill & Grossman, 1970). These tasks can be represented as S-R associations between environmental cues (usually explicit) and simple running responses.…”

Section: Dorsal Striatummentioning

confidence: 96%

Multiple Parallel Memory Systems in the Brain of the Rat

White

McDonald

2002

Neurobiology of Learning and Memory

813

625

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Effects of caudate lesions on the acquisition and retention of Sidman avoidance in the rat

Cited by 13 publications

References 11 publications

Infant rats can learn time intervals before the maturation of the striatum: evidence from odor fear conditioning

Infant rats can learn time intervals before the maturation of the striatum: evidence from odor fear conditioning

Differential effects of fornix and caudate nucleus lesions on two radial maze tasks: evidence for multiple memory systems

Multiple Parallel Memory Systems in the Brain of the Rat

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