Effects of cationic liposomes with stearylamine against virus infection

Tahara, Kohei; Kobayashi, Manami; Yoshida, Shuhei; Onodera, Risako; Inoue, Naoki; Takeuchi, Hirofumi

doi:10.1016/j.ijpharm.2018.04.001

Cited by 34 publications

(19 citation statements)

References 24 publications

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“…The SA liposomes are non-toxic and could increase antiviral effects by reducing cholesterol content, which intensify concurrently with increased binding of SA liposomes to the cell membrane. SA liposomes potentiate the entry of virus particles into host cells and are compatible with the antiviral drug acyclovir [163]. Hence, liposomes are the best carrier molecules to deliver antiviral drugs.…”

Section: Liposomesmentioning

confidence: 99%

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

et al. 2020

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Infectious diseases account for more than 20% of global mortality and viruses are responsible for about one-third of these deaths. Highly infectious viral diseases such as severe acute respiratory (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease (COVID-19) are emerging more frequently and their worldwide spread poses a serious threat to human health and the global economy. The current COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of 27 July 2020, SARS-CoV-2 has infected over 16 million people and led to the death of more than 652,434 individuals as on 27 July 2020 while also causing significant economic losses. To date, there are no vaccines or specific antiviral drugs to prevent or treat COVID-19. Hence, it is necessary to accelerate the development of antiviral drugs and vaccines to help mitigate this pandemic. Non-Conventional antiviral agents must also be considered and exploited. In this regard, nanoparticles can be used as antiviral agents for the treatment of various viral infections. The use of nanoparticles provides an interesting opportunity for the development of novel antiviral therapies with a low probability of developing drug resistance compared to conventional chemical-based antiviral therapies. In this review, we first discuss viral mechanisms of entry into host cells and then we detail the major and important types of nanomaterials that could be used as antiviral agents. These nanomaterials include silver, gold, quantum dots, organic nanoparticles, liposomes, dendrimers and polymers. Further, we consider antiviral mechanisms, the effects of nanoparticles on coronaviruses and therapeutic approaches of nanoparticles. Finally, we provide our perspective on the future of nanoparticles in the fight against viral infections.

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Section: Liposomesmentioning

confidence: 99%

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

et al. 2020

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“…An in vivo study was carried out in several mammalian cell lines, including A549 cells, that show a significant reduction in the viral load without any toxic effect. The antiviral potency of SA liposomes can further be altered by reducing the concentration of cholesterol, which increases the induced strong bond interaction with the viral capsid [92]. Further, recent advancement in the nano formulation leads to development of hybrid combination of carbon-based nanoparticles with liposomes.…”

Section: Liposomesmentioning

confidence: 99%

Recent Advancement in Nanotechnology-Based Drug Delivery System Against Viral Infections

et al. 2021

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In the last few decades, the exponential rise in the incidence of viral infections sets a global health emergency across the world. The biomimetic architecture, the ability to hijack host immune responses, continuous antigen shifting, and drafting are the major critical factors that are responsible for the unavailability of a concrete therapeutic regimen against viral infections. Further, inappropriate pharmacodynamic physicochemical and biological parameters such as low aqueous solubility, poor permeability, high affinity for plasm proteins, short biological half-lives, and fast elimination from the systemic circulation are the major critical factors that govern the suboptimal drug concentration at the target site that leads to the development of drug resistance. To address this issue, nanotechnology-based drug delivery approach is emerged as an altering method to attain the optimal drug concentration at the target site for a prolonged period by integrating the nanoengineering tools in the synthesis of nanoparticles. Nanodimensional configuration with enhanced permeability and retention effect, increased surface-area-to-volume ratio, provision for surface functionalization, etc., are the privileged aspects that make it an effective drug delivery system for dispensing the antiviral therapeutics. However, size, shape, charge, and surface topology of nanoparticles are the greater influential factors that determine target-specific drug delivery, optimum cellular uptake, degree of opsonization by the host immune cells, drug retention time, transcytosis, the extension of biological half-life, in vivo stability, and cytotoxicity. The review will enlighten the elaborative role of nanotechnology-based drug delivery and the major challenging aspect of clinical safety and efficacy.

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“…Relevant antiviral strategies are gaining more attention since the outbreak of COVID‐19, as researchers are looking for similarities among pathogenic viruses instead of only developing traditional point‐to‐point methodology . Numerous antiviral agents targeting the viral envelope were reported, including titanium dioxide (TiO 2 ) nanomaterials, silica nanoparticles (SiNPs), liposomes, peptides, etc. For example, Jackman et al.…”

Section: Antiviral Principles and Mechanismsmentioning

confidence: 99%

“…prepared a kind of cationic liposomes incorporated with stearylamine (SA) and proved their antiviral activity against recombinant baculovirus without loading active pharmaceutical ingredients. They demonstrated that the binding of SA liposomes to host cell membranes prevented viral entry and the antiviral activity of SA liposomes on HSV‐1 is comparable to that of antiviral drug acyclovir …”

Section: Detailed Description Of Various Antiviral Materialsmentioning

confidence: 99%

Advances in Antiviral Material Development

Liang

Ahamed

et al. 2020

ChemPlusChem

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His current research interests include Environmental Impact Assessment, Toxicity, Waste Management, and Electrochemical applications. He has worked in various government-funded and consulting projects at NTU. He is trained in Life Cycle Assessment tools such as GaBi and SimaPro, Nanotools such as AFM, Ellipsometry, ATR-FTIR and QCMD, USEtox® 2.0-Characterization fact. Liya Ge obtained her B.Eng. in chemical engineering from Zhejiang University, China in 1999. From 1999-2002, she worked as an Engineer in State Oceanic Administration, China. She subsequently completed her PhD study in analytical chemistry from Nanyang Technological University (NTU), Singapore in 2005. Since then, Dr. Ge has been working as a researcher and later a senior researcher in NTU. Her current research interests cover analytical chemistry including the development of sensors, biosensors and micro total analysis systems for rapid on-site detection and point-of-care diagnosis. Xiaoxu Fu is currently a PhD student at the School of Civil and Environmental Engineering at Nanyang Technological University (NTU), Singapore. He got his master degree in the same school in NTU and his bachelor degree in Shanghai Jiao Tong university in China. His scienfic research and interest is focused on conducting polymers and their application on biomedical, analytical and environmental applications. Grzegorz Lisak obtained his M.Sc. (Chem. Eng.) in physical chemistry in 2007 from Poznań University of Technology, Poland. He obtained his D.Sc. (Tech.

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Effects of cationic liposomes with stearylamine against virus infection

Cited by 34 publications

References 24 publications

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

Recent Advancement in Nanotechnology-Based Drug Delivery System Against Viral Infections

Advances in Antiviral Material Development

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