Effects of catecholamine depleting agents on noradrenaline blood pressure reversal

光, 小澤; 裕, 丸山

doi:10.1254/fpj.61.387

Folia Pharmacologica Japonica

1965

DOI: 10.1254/fpj.61.387

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Effects of catecholamine depleting agents on noradrenaline blood pressure reversal

小澤光¹,

丸山裕²

Abstract: Bloodpressure reversal in urethane anesthetized rat.Action of noradrenaline (NA) in rat pretreated with reserpine 2mg/kg/day for first two days and ]mg/kg/day for next two days before experiment.

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1969

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SUPERSENSITIVITY TO ISOPROTERENOL AND a NEW ADRENERGIC Β-Mimetic AGENT TRIMETHOQUINOL ON THE BLOOD PRESSURE OF THE RESERPINE TREATED RAT

Ozawa

Otsuki

Shiroishi

1969

Japanese Journal of Pharmacology

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Supersensitivity to catecholamines in various organs after reserpine treatment has been reported by many investigators. Trendelenburg et al.(1) described that this action was associated with the impairment of uptake of catecholamines to adrenergic nerve terminals.On the other hand isoproterenol, one of the catecholamines, was not retained by the heart (2). Neither cocaine (3) nor denervation (4) could cause' supersensitivity to this amine.However, Fleming et al. (5) reported that after reserpine 'treatment the isolated ileum of rabbit became more sensitive to isoproterenol and recently Khan et al. (6) also showed that on the isolated rat fundus strip preparation reserpine and guanethidine increased the sensitivity to isoproterenol. But further evidences for these phenomena were not obtained.In a previous paper (7) authors reported briefly that on the blood pressure of the rat treated with reserpine the hypotensive action of isoproterenol was potentiated.In order to confirm our previous results, the effects of reserpine on the sensitivity to isoproterenol and a new adrenergic Q-stimulating agent trimethoquinol (8) were studied on the blood pressure of the rat. METHODS AND MATERIALSMale albino rats of Wistar strain were anesthetized with urethane 1.0-1.6 g/kg by subcutaneous injection.The blood pressure was recorded from the carotid artery with a mercury manometer or electrotransducer.Schedules of pretreatment with reserpine were as follows : The dose was 2 mg/kg/day on the first two days and 1 mg/kg/day on the next two days were given subcutaneously prior the experiments.Isoproterenol and trimethoquinol were given intravenously in doses ranging from 0.001 to 1,000 pg/kg.Injections were made into jugular vein via cannulated polyethylene tube.

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SUPERSENSITIVITY TO ISOPROTERENOL AND a NEW ADRENERGIC Β-Mimetic AGENT TRIMETHOQUINOL ON THE BLOOD PRESSURE OF THE RESERPINE TREATED RAT

Ozawa

Otsuki

Shiroishi

1969

Japanese Journal of Pharmacology

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show abstract

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Effects of catecholamine depleting agents on noradrenaline blood pressure reversal

Abstract: Bloodpressure reversal in urethane anesthetized rat.Action of noradrenaline (NA) in rat pretreated with reserpine 2mg/kg/day for first two days and ]mg/kg/day for next two days before experiment.

Cited by 1 publication

References 0 publications

SUPERSENSITIVITY TO ISOPROTERENOL AND a NEW ADRENERGIC Β-Mimetic AGENT TRIMETHOQUINOL ON THE BLOOD PRESSURE OF THE RESERPINE TREATED RAT

SUPERSENSITIVITY TO ISOPROTERENOL AND a NEW ADRENERGIC Β-Mimetic AGENT TRIMETHOQUINOL ON THE BLOOD PRESSURE OF THE RESERPINE TREATED RAT

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