Effects of cataract surgery in Japanese patients with neovascular age-related macular degeneration

Abstract

Purpose To investigate the effects of cataract surgery in Japanese patients with neovascular age-related macular degeneration (nAMD). Methods The primary endpoint in this prospective, observational study was patient satisfaction at 6 months after cataract surgery in patients with nAMD. Secondary endpoints comprised changes in best-corrected visual acuity (BCVA), M-chart score, central retinal thickness (CRT), AMD status, and number of AMD treatments. All examinations were performed before surgery, and at 1, 3, and 6 months postoperatively. Results Fifty patients (52 eyes) were included in this study (32 men; mean age, 76.1 ± 7.1 years). Thirty-nine patients (75.0%) reported satisfaction with cataract surgery. BCVA significantly improved at all postoperative timepoints (all p < 0.0001), whereas differences in M-chart scores were not statistically significant. The number of eyes with BCVA ≤ 0.3 logarithm of the minimum angle of resolution (logMAR) increased from 21 to 38; however, CRT did not change. The number of AMD treatments did not change during follow-up. All questionnaire scores showed postoperative improvement. Univariate and multivariate analyses revealed that final BCVA ≤ 0.3 logMAR was significantly associated with patient satisfaction. Conclusion Cataract surgery significantly improved vision in Japanese patients with nAMD, without affecting AMD status. Patients were satisfied with cataract surgery, especially with respect to improvement of distance vision.

The Effect of Intravitreal Bevacizumab Injection in Wet Age-Related Macular Degeneration Patients with Cataract Surgery

“…AREDS (age-related eye disease study)는 나이관련황반변성을 진단받은 1,939안을 대상으로 시행한 코호트 연구로 백내장 수술을 시행하 고 최소 18개월까지 경과를 보았고 그 기간 내에 유의한 시력호전 을 보였다고 하였다[33]. 그 외에도 백내장수술이 나이관련황반변 성의 질병 활성도에 영향을 미치지 않으며 시력 호전을 보인다는 연구는 다수 있었다[34][35][36]. 그러므로 백내장 수술과 동시에 유리 체강내 베바시주맙 주입술을 시행하는 경우 발생할 수 있는 백내장 수술 후 발생할 수 있는 황반부종을 억제할 수 있을 것으로 생각되 었다.…”