Effects of castration and testosterone in male mice on Schistosoma mansoni

Berg, Edward

doi:10.1016/0035-9203(57)90127-x

Cited by 23 publications

(6 citation statements)

References 14 publications

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“…Fewer worms develop in male rodent hosts than in females and castration and exogenous hormones have the expected effects (Berg 1957, Nakazawa et al 1997. Fulford et al (1998) propose that in mice and in humans that this might be related to dehydroepiandrosterone levels.…”

Section: Worm Development Fecundity and Fecal Egg Excretionmentioning

confidence: 99%

Experimental models of Schistosoma mansoni infection

Cheever

Lenzi²,

Lenzi³

et al. 2002

Mem. Inst. Oswaldo Cruz

121

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Section: Worm Development Fecundity and Fecal Egg Excretionmentioning

confidence: 99%

Experimental models of Schistosoma mansoni infection

Cheever

Lenzi²,

Lenzi³

et al. 2002

Mem. Inst. Oswaldo Cruz

121

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“…Mathies (1954Mathies ( , 1959 showed a similar relationship between infections of male and female mice with Aspicularis tetraptera; he also found that gonadectomy significantly lowered the worm burden and that oestradiol administered to the male mouse was detrimental to the establishment of heavy infections, while testosterone had little or no effect in either male or female mice. Berg (1953Berg ( ,1957 showed that injection of testosterone into mice infected with Schistosoma mansoni lowered the survival of the parasite, but Robinson (1959) denied any such modification of the survival rate. It is worthy of note that a sex difference to an infection may occur in invertebrate hosts.…”

Section: Introductionmentioning

confidence: 99%

Certain aspects of the host-parasite relationship of Nematospiroides dubius (Baylis). I. Resistance of male and female mice to experimental infections

Dobson

1961

Parasitology

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1. It has been shown that there is a difference between the resistance of male and female mice to infection with Nematospiroides dubius.2. More parasites were harboured, during both the larval and adult parasitic phases, by male mice.3. These worms were found to occupy a similar relative length of the intestine between the stomach and the caecum in male and female mice infected for either 5 or 10 days.4. The relative length of the intestine infected on the fifth day was significantly greater than that infected on the tenth day.This investigation was carried out during the tenure of a Research Studentship from the Department of Scientific and Industrial Research. I should like to thank Professor I. Chester Jones, in whose department the work was done, for the facilities provided and Dr E. T. B. Francis for his helpful and critical supervision.

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“…57 Female mice manifested a heavier worm burden than males during chronic infection, as the presence of testosterone results in decreased schistosome survival and increased host survival in experimental infections, and the extent of pulmonary vascular remodeling correlated with levels of inflammatory cytokines and lung egg burden. [58][59][60] The complement systems of mice and rats are different, and rats have natural immunity to schistosomiasis infection, which suggests that the complement signaling system may play a critical role in regulating proinflammatory and pro-proliferative processes in the initiation of PH. 61,62 Praziquantel can prevent development of Sch-PAH in female mice and reverse established pulmonary vascular remodeling, with significantly reduced mRNA expression of IL-13, IL-8, and IL-4 in lungs.…”

Section: Schistosome-related Pahmentioning

confidence: 99%

Experimental animal models of pulmonary hypertension: Development and challenges

Ding

et al. 2022

Anim Models and Exp Med

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Pulmonary hypertension (PH) is a severe, progressive vascular disorder characterized by elevation in pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR), finally leading to right heart failure and death. During the rise in PAP and PVR, vascular remodeling is accompanied by accumulation of pulmonary artery smooth muscle cells (PASMCs), endothelial cells (ECs), fibroblasts, myofibroblasts and pericytes in pulmonary arterial wall, which leads to thickening of the inner and outer linings of blood vessels, loss and obstructive remodeling of the pulmonary vascular bed and perivascular inflammation. 1-3 Associated with multiple primary causes, PH encompasses a group of clinical entities. According to the latest classification proposed by the Sixth World Symposium on PH, the disease can develop due to pulmonary arterial disorder, left heart disease, lung disease or hypoxia, chronic thromboembolic disease and other unclear or multifactorial mechanisms. 4 Though current treatments can improve clinical symptoms and hemodynamic abnormality to some extent, it is difficult to target pulmonary vascular remodeling and

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Effects of castration and testosterone in male mice on Schistosoma mansoni

Cited by 23 publications

References 14 publications

Experimental models of Schistosoma mansoni infection

Experimental models of Schistosoma mansoni infection

Certain aspects of the host-parasite relationship of Nematospiroides dubius (Baylis). I. Resistance of male and female mice to experimental infections

Experimental animal models of pulmonary hypertension: Development and challenges

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