Effects of castration and testosterone on Fel d I production by sebaceous glands of male cats: I—immunological assessment

Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen

“…Bastien et al observed an 80‐fold difference in salivary Fel d 1 levels between the lowest‐producing and highest‐producing cats in a 64‐cat group and up to a 76‐fold difference between the lowest and highest salivary Fel d 1 levels in individual cats. Studies have shown that male cats produce 3‐5 times less Fel d 1 after neutering; these findings, combined with observations that Fel d 1 production could be restored to preneutering levels with the administration of exogenous testosterone, suggest an influential role of testosterone on Fel d 1 production …”

Secretoglobins: Sexually Dimorphic Expression of Androgen-Binding Protein mRNA in Mouse Lacrimal Glands

“…30 Fel dI production was regulated by androgens. 31,47 In rat, the C3 component of prostatein was expressed in male lacrimal glands, but not in female glands and not in the lacrimal glands of castrated males or testicular feminized animals. 7 Androgen administration induced C3 mRNA and protein expression in female and in castrated male lacrimal glands.…”

Structural Characterization of the Tetrameric form of the Major Cat Allergen Fel d 1

“…22 Uteroglobin, CC16 and ABP may carry ligands such as steroids, 17,18,23,24 and the expression of both uteroglobin and CC16 in epithelial cells is controlled by steroids. 18,[25][26][27] It has been demonstrated that both natural and recombinant uteroglobin are potent inhibitors of extracellular phospholipase A 2 (PLA 2 ) activity 28 and that these anti-inflammatory activities appear to reside in a nonapeptide region (corresponding to residues 39-47) of the third α-helix of uteroglobin. 29, 30 Chowdhury et al thereafter assessed the critical role of residues Lys43 and Asp46 of uteroglobin for its PLA 2 -inhibitory activity.…”