Effects of Cassava Juice (Manihot esculenta Crantz) on Renal and Hepatic Function and Motor Impairments in Male Rats

Abstract

Cassava (Manihot esculenta Crantz) is a plant that contains neurotoxins such as linamarin and lotaustraline. Its long-term consumption is associated with neuronal damage and contributes to the development of motor impairment in humans and rats. We investigated the effects of the consumption of cassava juice on renal and hepatic function and motor impairments in male rats. The rats received the vehicle, non-toxic and toxic doses of cassava juice, or linamarin as a pharmacological control, over 35 consecutive days. The effects were evaluated in an open field test, rotarod, and swim test. The toxic cassava dose and linamarin resulted in motor impairments in the rotarod and swim test from day 7 of treatment. The toxic cassava dose and linamarin increased the parameters that indicate renal and hepatic damage, with the exception of total protein and albumin levels. Behavioral variables that show motor incoordination (i.e., latency to fall in the rotarod) were negatively correlated with biochemical parameters of renal and kidney damage, whereas spin behavior was positively correlated. Our data indicate that chronic oral consumption of cassava juice caused renal and hepatic damage that was correlated with motor coordination impairment in rats, similarly to their principal neurotoxic compound, linamarin.

Exploration of Maternal and Fetal Toxicity Risks for Metronidazole-Related Teratogenicity and Hepatotoxicity through an Assessment in Albino Rats

“…Based on the present findings, the GIII group increased the levels of ALT, AST, and ALP, and the changes were more evident with an increase in the experimental period (0-20th dpc). In general, increases in serum concentration levels of ALT, AST, ALP, and TP are biological markers of hepatic damage [54]. The effect on the liver, a pivotal organ of metabolic homeostasis, is reflected in the levels of AST [55].…”

Laparoscopic versus open hepatectomy for intrahepatic cholangiocarcinoma in patients aged 60 and older: a retrospective cohort study

“…Second, a substantial proportion of patients lacked sufficient c-reactive protein (CRP) levels; thus, CRP/Alb ratios could not be calculated [24][25][26]. The total bilirubin level (TBIL) is a significant index of liver function [27][28][29][30], and thus, TBIL was monitored and high TBIL was promptly treated. Additionally, TBIL was an important independent prognosis predictor for ICC patients [31][32][33] and was significantly higher in the OH than LH group on the first postoperative blood tests (Table 3).…”