Effects of carvacrol on ketamine-induced cardiac injury in rats: an experimental study

Karakurt, Tülay Ceren Ölmeztürk; Emir, İzzet; Bedir, Zehra; Erdem, Kezban Tuna Ozkaloglu; Süleyman, Halis; Sarıgül, Cengiz; Mendil, Ali Sefa

doi:10.1080/01480545.2022.2155664

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…The protective effects of carvacrol on ketamine‐induced cardiotoxicity were shown by decreasing the levels of MDA, TNF‐α, IL‐1β, and IL‐6 in the tissue and increasing the levels of antioxidant parameters such as in tissue glutathione (GSH) and SOD levels in the heart tissues (Ölmeztürk Karakurt et al., 2022 ). Carvacrol could mitigate the negative effects of ketamine by preventing lipid peroxidation and inflammatory response.…”

Section: Resultsmentioning

confidence: 99%

Protective effects of carvacrol on lipid profiles, oxidative stress, hypertension, and cardiac dysfunction – A comprehensive review

Khazdair,

Moshtagh,

Anaeigoudari

et al. 2024

Food Science & Nutrition

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Cardiovascular diseases (CVDs) are a class of illnesses that affect the heart or blood vessels, leading to the most common causes of death worldwide. In 2017, CVD caused approximately 17.8 million deaths that were increased approximately to 20.5 million deaths in 2021, globally. Also, nearly 80% of worldwide CVD deaths occur in some countries. Some herbs and their constituents due to their several pharmacological activities have been used for medicinal purposes. Carvacrol is a phenolic mono‐terpenoid found in the oils of aromatic herbs with several biological properties. The possible therapeutic effects of carvacrol on lipid profiles, oxidative stress, hypertension, and cardiac dysfunction were summarized in the current study. The data from this review article were obtained by searching the terms including; “Carvacrol”, “Hypertension”, Hypotensive, “Cardiac dysfunction”, “Ischemia”, “Lipid profile”, and Oxidative stress in several web databases such as Web of Sciences, PubMed Central, and Google Scholar, until November 2023. The results of the reviewed studies revealed that carvacrol inhibits acetylcholinesterase (AchE) activity and alters lipid profiles, reducing heart rate as well as systolic and diastolic blood pressure (BP). Carvacrol also decreased the proinflammatory cytokine (IL‐1β), while increasing secretion of anti‐inflammatory cytokine (IL‐10). Moreover, carvacrol improved oxidative stress and mitigated the number of apoptotic cells. The pharmacological effects of carvacrol on CVD might be through its antioxidative, anti‐inflammatory, and antiapoptotic effects. The mentioned therapeutic effects of carvacrol on lipid profile, hypertension, and cardiac dysfunction indicate the possible remedy effect of carvacrol for the treatment of CVD.

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Section: Resultsmentioning

confidence: 99%

Protective effects of carvacrol on lipid profiles, oxidative stress, hypertension, and cardiac dysfunction – A comprehensive review

Khazdair,

Moshtagh,

Anaeigoudari

et al. 2024

Food Science & Nutrition

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“…Carvacrol leads to reduced levels of inflammatory factors [19,20], inhibits the formation of atheroma plaques [21], increases the levels of antioxidant enzymes and activation of endothelial nitric oxide synthase (eNOS) [22], and reduces senescence cell [23]. Furthermore, carvacrol instigates the angiogenesis of human mesenchymal cells by modulating the differentiation of these cells [24].…”

Section: Introductionmentioning

confidence: 99%

Carvacrol Improves Vascular Function in Hypertensive Animals by Modulating Endothelial Progenitor Cells

et al. 2023

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Carvacrol, a phenolic monoterpene, has diverse biological activities, highlighting its antioxidant and antihypertensive capacity. However, there is little evidence demonstrating its influence on vascular regeneration. Therefore, we evaluated the modulation of carvacrol on endothelial repair induced by endothelial progenitor cells (EPC) in hypertension. Twelve-week-old spontaneously hypertensive rats (SHR) were treated with a vehicle, carvacrol (50 or 100 mg/kg/day), or resveratrol (10 mg/kg/day) orally for four weeks. Wistar Kyoto (WKY) rats were used as the normotensive controls. Their systolic blood pressure (SBP) was measured weekly through the tail cuff. The EPCs were isolated from the bone marrow and peripherical circulation and were quantified by flow cytometry. The functionality of the EPC was evaluated after cultivation through the quantification of colony-forming units (CFU), evaluation of eNOS, intracellular detection of reactive oxygen species (ROS), and evaluation of senescence. The superior mesenteric artery was isolated to evaluate the quantification of ROS, CD34, and CD31. Treatment with carvacrol induced EPC migration, increased CFU formation and eNOS expression and activity, and reduced ROS and senescence. In addition, carvacrol reduced vascular ROS and increased CD31 and CD34 expression. This study showed that treatment with carvacrol improved the functionality of EPC, contributing to the reduction of endothelial dysfunction.

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Carvacrol and its effect on cardiovascular diseases: From molecular mechanism to pharmacological modulation

Mansi,

Garg,

Sahu

2024

Food Bioscience

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Effects of carvacrol on ketamine-induced cardiac injury in rats: an experimental study

Cited by 3 publications

References 28 publications

Protective effects of carvacrol on lipid profiles, oxidative stress, hypertension, and cardiac dysfunction – A comprehensive review

Protective effects of carvacrol on lipid profiles, oxidative stress, hypertension, and cardiac dysfunction – A comprehensive review

Carvacrol Improves Vascular Function in Hypertensive Animals by Modulating Endothelial Progenitor Cells

Carvacrol and its effect on cardiovascular diseases: From molecular mechanism to pharmacological modulation

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