Effects of carnosine on long-term plasticity of medial perforant pathway/dentate gyrus synapses in urethane-anesthetized rats: an in vivo model

Süer, Cem; Dolu, Nazan; Artis, S.; Aydoğan, Sami

doi:10.1007/s00221-009-1899-x

Cited by 10 publications

(2 citation statements)

References 40 publications

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“…Monophasic 10 V and 0.175-ms pulses were generated by the A/D board (Powerlab/8SP, ADInstruments, Colorado Springs, CO, USA) of a computer and triggered to a stimulator which was connected to an isolator (Suer et al, 2009). Biological signals were amplified (1000×).…”

Section: Methodsmentioning

confidence: 99%

Effects of cold exposure on behavioral and electrophysiological parameters related with hippocampal function in rats

Elmarzouki

Aboussaleh

Bitiktas

et al. 2014

Front. Cell. Neurosci.

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Aim: Behavioral and mental changes may occur in people exposed to cold stress by decreasing their work efficiency and their mental capacity while increasing the number of accidents on the job site. The goal of this study was to explore the effect of cold stress in spatial learning performance excitability and LTP.Materials and Methods: Three to four month old rats were randomly divided into four groups to form a control group and a cold stress group for each sex. The groups of cold stressed animals were placed in a cold room ambient temperature of 4°C for 2 h day. Adrenal glands and body weight (g) were recorded in control and stressed rats during the cold exposure. Spatial learning (acquisition phase) and memory (probe trial) were tested in the Morris water maze (MWM) immediately after daily exposure. Latency to locate the hidden platform, distance moved (DM), mean distance to platform, swim speed (SS) and time spent in the platform quadrant were compared between genders and treatments. Field potential recordings were made, under urethane anesthesia, from the dentate gyrus (DG) granule-cell layer, with stimulation of the medial perforant pathway 2 h after the probe trial. This study examined spatial memory as measured by MWM performance and hippocampal long-term potentiation (LTP) in the DG after exposure to cold in a repeated stress condition for 2 h/day for 5 days.Results: The cold-exposed female rats needed less time to find the hidden platform on day 1 (43.0 ± 13.9 s vs. 63.2 ± 13.2 s), day 2 (18.2 ± 8.4 s vs. 40.9 ± 12.2 s) and on day 4 (8.0 ± 2.1 s vs. 17.2 ± 7.0 s) while cold-exposed male rats showed a decreased escape latency (EL) on day 1 only (37.3 ± 12.5 s vs. 75.4 ± 13.1 s). Cold-exposed male rats spent less time in the target quadrant (30.08 ± 6.11%) than the control male rats (37.33 ± 8.89%). Two hour cold exposure decreased population spike (PS) potentiation during both induction (218.3 ± 21.6 vs. 304.5 ± 18.8%) and maintenance intervals (193.9 ± 24.5 vs. 276.6 ± 25.4%) in male rats. Meanwhile cold exposure did not affect the body weight (C: 221 ± 2.5 vs. S: 222 ± 1.7) but it impacts the adrenal gland relative weight (S: 27.1 ± 1.8 mg vs. C: 26.2 ± 1.4 mg).Conclusion: Overall, the results show that repeated cold exposure can selectively improve spatial learning in adult female rats, but impaired retention memory for platform location in male rats. It is possible that impaired LTP underlies some of the impaired retention memory caused by cold exposure in the male rats.

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Section: Methodsmentioning

confidence: 99%

Effects of cold exposure on behavioral and electrophysiological parameters related with hippocampal function in rats

Elmarzouki

Aboussaleh

Bitiktas

et al. 2014

Front. Cell. Neurosci.

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“…In addition to these glutamate regulators with a wide range of efficacy, the last two decades of neuropsychopharmacology research has concentrated on complementary and herbal medicine to develop more effective and less expensive therapeutic agents with safer side effect profiles for alleviating symptoms of mood and behavioral disorders ( 94 , 95 ). In an in-vivo experiment, Süer et al reported that L-carnosine might also play a role in synaptic plasticity ( 96 ). Multiple studies have revealed that the application of L-carnosine would be of benefit in neuropsychiatric disorders, including autism, schizophrenia, obsessive-compulsive disorder, attention-deficit hyperactivity disorder, major depression disorder, Alzheimer’s, and Parkinson’s diseases ( 97 , 98 ).…”

Section: Discussionmentioning

confidence: 99%

Ketamine and other Glutamate Receptor Modulating Agents for Treatment-Resistant Depression: A Systematic Review of Randomized Controlled Trials

Shamabadi¹,

Ahmadzade²,

Aqamolaei³

et al. 2022

IJPS

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Objective: Available treatments of depression have limited efficacy and unsatisfactory remission rates. This study aims to review randomized controlled trials (RCTs) investigating effects of glutamate receptor modulators in treating patients with resistant depression. Method: The study protocol was registered in PROSPERO (CRD42021225516). Scopus, ISI Web of Science, Embase, Cochrane Library, Google Scholar, and three trial registries were searched up to September 2020 to find RCTs evaluating glutamate receptor modulators for resistant depression. The difference between intervention and control groups in changing depression scores from baseline to endpoint was considered the primary outcome. Version 2 of the Cochrane risk-of-bias tool for randomized trials was used to assess the quality of the RCTs. No funding was received. Results: Thirty-eight RCTs were included. Based on the included studies, compelling evidence was found for ketamine (with or without electroconvulsive therapy, intravenous or other forms), nitrous oxide, amantadine, and rislenemdaz (MK-0657); the results for MK-0657, amantadine, and nitrous oxide were only based on one study for each. Lithium, lanicemine, D-cycloserine, and decoglurant showed mixed results for efficacy, and, riluzole, and 7-chlorokynurenic acid were mostly comparable to placebo. A limited number of studies were available that addressed drugs other than ketamine. Conclusion: The study cannot determine the difference between statistical and clinical significance between the agents and placebo due to high heterogeneity among the RCTs. Nevertheless, ketamine could be used as an efficacious drug in TRD; still, additional studies are needed to delineate the optimum dosage, duration of efficacy, and intervals. Further studies are also recommended on the effectiveness of glutamatergic system modulators other than ketamine on treatment-resistant depression.

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Carnosine as an effective neuroprotector in brain pathology and potential neuromodulator in normal conditions

et al. 2018

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Effects of carnosine on long-term plasticity of medial perforant pathway/dentate gyrus synapses in urethane-anesthetized rats: an in vivo model

Cited by 10 publications

References 40 publications

Effects of cold exposure on behavioral and electrophysiological parameters related with hippocampal function in rats

Effects of cold exposure on behavioral and electrophysiological parameters related with hippocampal function in rats

Ketamine and other Glutamate Receptor Modulating Agents for Treatment-Resistant Depression: A Systematic Review of Randomized Controlled Trials

Carnosine as an effective neuroprotector in brain pathology and potential neuromodulator in normal conditions

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