Effects of Cardiac Rehabilitation on High-Density Lipoprotein-mediated Cholesterol Efflux Capacity and Paraoxonase-1 Activity in Patients with Acute Coronary Syndrome

Furuyama, Fumiaki; Koba, Shinji; Yokota, Yuya; Tsunoda, Fumiyoshi; Miyake, Shoji; Kobayashi, Youichi

doi:10.5551/jat.41095

Cited by 17 publications

(14 citation statements)

References 55 publications

(63 reference statements)

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“…However, we found no correlation between circulating HDL cholesterol levels and cholesterol efflux capacity in control subjects and ACS patients. Furuyama F et al in their study on effect of cardiac rehabilitation on HDL function have also shown significant correlation of CEC and ARE with apoA-I levels rather than HDL-cholesterol levels [22]. This may be because cholesterol content makes up only about 20% of the HDL particle and even that proportion differs between different HDL particles.…”

Section: Discussionmentioning

confidence: 93%

HDL functions and their interaction in patients with ST Elevation Myocardial Infarction: a case control study

Thakkar

Vincent

Roy

et al. 2020

Preprint

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Background : Recent studies emphasize the importance of HDL function over HDL cholesterol measurement, as an important risk for cardiovascular diseases (CVD). We compared the HDL function of patients with Acute Coronary Syndrome (ACS) and healthy controls. Methods : We measured cholesterol efflux capacity of HDL using THP-1 macrophages labelled with fluorescently tagged (BODIPY) cholesterol. Paraoxonase and arylesterase activity of PON1 enzyme were assessed by spectrophotometric methods. Results : We recruited 151 ACS patients and 110 controls. The HDL function of all patients during acute phase and at six month follow-up was measured. The mean age of the patients and controls was 51.7 and 43.6 years respectively. The mean HDL cholesterol/apolipoprotein A-I levels (ratio) of patients during acute phase, follow-up and of controls were 40.2 mg/dl/ 112.5 mg/dl (ratio= 0.36), 38.3 mg/dl/ 127.2 mg/dl (ratio= 0.30) and 45.4 mg/dl/ 142.1 mg/dl (ratio=0.32) respectively. The cholesterol efflux capacity (CEC) of HDL was positively correlated with apolipoprotein A-I levels during acute phase (r = 0.19, p = 0.019), follow-up (r = 0.26, p = 0.007) and of controls (r = 0.3, p = 0.0012) but not with HDL-C levels (acute phase: r = 0.07, p = 0.47; follow-up: r = 0.1 , p = 0.2; control: r = 0.02, p = 0.82). Higher levels of cholesterol efflux capacity, PON1 activity and apolipoprotein A-I were associated with lower odds of development of ACS. We also observed that low CEC is associated with higher odds of having ACS if PON1 activity of HDL is also low and vice versa. Conclusion : ACS is associated with reduced HDL functions which improves at follow-up. The predicted probability of ACS depends upon individual HDL functions and the interactions between them.

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Section: Discussionmentioning

confidence: 93%

HDL functions and their interaction in patients with ST Elevation Myocardial Infarction: a case control study

Thakkar

Vincent

Roy

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…However, we found no correlation between circulating HDL cholesterol levels and cholesterol efflux capacity in control subjects and ACS patients. Furuyama F et al in their study on effect of cardiac rehabilitation on HDL function have also shown significant correlation of CEC and ARE with apoA-I levels rather than HDL-cholesterol levels [20]. This may be because cholesterol content makes up only about 20% of the HDL particle and even that proportion differs between different HDL particles.…”

Section: Discussionmentioning

confidence: 93%

HDL functions and their interaction in patients of ST Elevation MI Acute Coronary Syndrome: a case control study

Thakkar¹,

Vincent²,

Roy³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Recent studies emphasize the importance of HDL function over HDL cholesterol measurement, as an important risk for cardiovascular diseases (CVD). We compared the HDL function of patients with Acute Coronary Syndrome (ACS) and healthy controls. Methods:We measured cholesterol efflux capacity of HDL using THP-1 macrophages labelled with fluorescently tagged (BODIPY) cholesterol. Paraoxonase and arylesterase activity of PON1 enzyme were assessed by spectrophotometric methods. Results: We recruited 151 ACS patients and 110 controls. The HDL function of all patients during acute phase and at six month follow-up was measured. The mean age of the patients and controls was 51.7 and 43.6 years respectively. The mean HDL cholesterol/apolipoprotein A-I levels (ratio) of patients during acute phase, follow-up and of controls were 40.2 mg/dl/ 112.5 mg/dl (ratio= 0.36), 38.3 mg/dl/ 127.2 mg/dl (ratio= 0.30) and 45.4 mg/dl/ 142.1 mg/dl (ratio=0.32) respectively. The cholesterol efflux capacity (CEC) of HDL was positively correlated with apolipoprotein A-I levels duringacute phase (r = 0.19, p = 0.019), follow-up (r = 0.26, p = 0.007) and of controls (r = 0.3, p = 0.0012) but not with HDL-C levels (acute phase: r = 0.07, p = 0.47; follow-up: r = 0.1 , p = 0.2; control: r = 0.02, p = 0.82). Higher levels of cholesterol efflux capacity, PON1 activity and apolipoprotein A-I were associated with lower odds of development of ACS. We also observed that low CEC is associated with higher odds of having ACS if PON1 activity of HDL is also low and vice versa.Conclusion: ACS is associated with reduced HDL functions which improves at follow-up. The predicted probability of ACS depends upon individual HDL functions and the interactions between them.

show abstract

“…However, we found no correlation between circulating HDL cholesterol levels and cholesterol efflux capacity in control subjects and ACS patients. Furuyama F et al in their study on effect of cardiac rehabilitation on HDL function have also shown significant correlation of CEC and ARE with apoA-I levels rather than HDLcholesterol levels [22]. This may be because cholesterol content makes up only about 20% of the HDL particle and even that proportion differs between different HDL particles.…”

Section: Discussionmentioning

confidence: 94%

HDL functions and their interaction in patients with ST elevation myocardial infarction: a case control study

et al. 2020

View full text Add to dashboard Cite

Background: Recent studies emphasize the importance of HDL function over HDL cholesterol measurement, as an important risk for cardiovascular diseases (CVD). We compared the HDL function of patients with acute coronary syndrome (ACS) and healthy controls. Methods: We measured cholesterol efflux capacity of HDL using THP-1 macrophages labelled with fluorescently tagged (BODIPY) cholesterol. PON1 activities toward paraoxon and phenyl acetate were assessed by spectrophotometric methods. Results:We recruited 150 ACS patients and 110 controls. The HDL function of all patients during acute phase and at six month follow-up was measured. The mean age of the patients and controls was 51.7 and 43.6 years respectively. The mean HDL cholesterol/apolipoprotein A-I levels (ratio) of patients during acute phase, follow-up and of controls were 40.2 mg/dl/ 112.5 mg/dl (ratio = 0.36), 38.3 mg/dl/ 127.2 mg/dl (ratio = 0.30) and 45.4 mg/dl/ 142.1 mg/dl (ratio = 0.32) respectively. The cholesterol efflux capacity (CEC) of HDL was positively correlated with apolipoprotein A-I levels during acute phase (r = 0.19, p = 0.019), follow-up (r = 0.26, p = 0.007) and of controls (r = 0.3, p = 0.0012) but not with HDL-C levels (acute phase: r = 0.07, p = 0.47; follow-up: r = 0.1, p = 0.2; control: r = 0.02, p = 0.82). Higher levels of cholesterol efflux capacity, PON1 activity and apolipoprotein A-I were associated with lower odds of development of ACS. We also observed that low CEC is associated with higher odds of having ACS if PON1 activity of HDL is also low and vice versa.Conclusion: ACS is associated with reduced HDL functions which improves at follow-up. The predicted probability of ACS depends upon individual HDL functions and the interactions between them.

show abstract

Effects of Cardiac Rehabilitation on High-Density Lipoprotein-mediated Cholesterol Efflux Capacity and Paraoxonase-1 Activity in Patients with Acute Coronary Syndrome

Cited by 17 publications

References 55 publications

HDL functions and their interaction in patients with ST Elevation Myocardial Infarction: a case control study

HDL functions and their interaction in patients with ST Elevation Myocardial Infarction: a case control study

HDL functions and their interaction in patients of ST Elevation MI Acute Coronary Syndrome: a case control study

HDL functions and their interaction in patients with ST elevation myocardial infarction: a case control study

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