Effects of carboxytherapy on skin laxity

Abstract

Background Carboxytherapy is capable of inducing tissue repair which results in an increase in elastic and collagen fibers. Objectives To evaluate the effects of carboxytherapy upon human skin collagen and elastic fiber synthesis. Methods Case study of nine volunteers who received a single application of carboxytherapy in the left infraumbilical region, with infusion rate of 100 mL/min and 0.6 mL/kg weight over an area of 25 cm2. After 60 days on average, the skin was collected for histological analysis and stained with picrosirius red for collagen and Verhoeff for elastic fibers. The percentage of fibers found was marked by the Image J® program and recorded in a Microsoft Excel spreadsheet. Statistical analysis was performed using SPSS (version 20), with a significance level of 95%. Results An increase in the collagen and elastic fibers sample was observed in the treated group. Morphometrically, a significant increase in the percentage of collagen in the Carboxytherapy group (41.44 ± 4.50%) was observed compared with the control group (37.44 ± 3.87%) with P = .04; for elastic fibers, the percentage showed no significant difference between the control group (10.55 ± 4.33%) and the carboxytherapy group (10.44 ± 3.71%). Conclusions Carboxytherapy with the parameters used in this study was able to stimulate collagen and elastic fiber synthesis, with significant differences in the morphometry for collagen fibers.

Carboxytherapy in dermatology: A systematic review

“…A case series by Oliveira et al 16 carried out a single session of carboxytherapy on the hypogastric region of nine females with a mean age of 45 years and evaluated the histological and histomorphometric changes 60 days after. They found that except for one case (Fitzpatrick skin phototype III), the rest showed significant collagen synthesis improvement.…”

Objective, measurable assessment of the elasticity of the skin around the eyes following the carboxytherapy treatment

“…The authors observed partial remodeling of the dermis and thickening of the epidermis. Oliveira et al 9 using histomorphometric evaluation reported a significant increase in the percentage of collagen after single carbon dioxide therapy. El‐Domyati et al revealed an improvement in facial texture and wrinkles correlating with clinical improvement in skin condition in the analysis performed with the use of 3D camera.…”

Associação de Carboxiterapia, Endermologia e Ativos no Tratamento de Estrias Albas: Uma Revisão de Literatura / Associação de Carboxiterapia, Endermologia e Ativos no Tratamento de Estrias Albas: Uma Revisão de Literatura

“…A administração de CO2 estimula um maior fluxo sanguíneo para a área injetada, aumentando consequentemente a formação de colágeno (HODEIB et al, 2018;OLIVEIRA et al, 2020). Segundo Pacheco (2011), o mecanismo de ação da carboxiterapia é, sobretudo, na microcirculação vascular do tecido conectivo, promovendo uma vasodilatação e um aumento da drenagem venolinfática.…”

“…A administração via subcutânea do CO2 promove aumento do fluxo sanguíneo oxigenado para a região afetada que se difunde para a microcirculação cutânea local, ocasionando a correção do desequilíbrio dos níveis de oxigênio e dióxido de carbono, fornecendo oxigênio e nutrientes para a pele e os vasos. Além disso, a administração local do CO2 estimula a síntese de colágeno pelos fibroblastos e a neoangiogênese, que combinados ao aumento do fluxo sanguíneo contribuem para a melhora do aspecto da pele (OLIVEIRA et al, 2020).…”