Effects of carboxymethyl-glucan from Saccharomyces cerevisiae on the peripheral blood cells of patients with advanced prostate cancer

Magnani, Marciane; Castro-Gomez, Raul Hernan; Aoki, Mateus Nóbrega; Gregório, Émerson Pereira; Libos, Farid; Watanabe, Maria Angélica Ehara

doi:10.3892/etm.2010.121

Cited by 15 publications

(17 citation statements)

References 17 publications

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“…In this regard, administration of carboxymethyl-glucan (CM-G), a water-soluble derivative of Saccharomyces cerevisiae, to advanced prostate cancer patients, has been reported to enhance hematopoietic regeneration. After CM-G administration, the total leukocyte, red blood cell and platelet counts, as well as hematocrit and hemoglobin increased significantly independently of changes in the lifestyle habits of patients [87].…”

Section: In Vivo Effects In Cancer Patientsmentioning

confidence: 96%

Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer?

Cornò

Gessani

Conti

2020

Cancers

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β-glucans represent a heterogeneous group of naturally occurring and biologically active polysaccharides found in many kinds of edible mushrooms, baker’s yeast, cereals and seaweeds, whose health-promoting effects have been known since ancient times. These compounds can be taken orally as food supplements or as part of daily diets, and are safe to use, nonimmunogenic and well tolerated. A main feature of β-glucans is their capacity to function as biological response modifiers, exerting regulatory effects on inflammation and shaping the effector functions of different innate and adaptive immunity cell populations. The potential to interfere with processes involved in the development or control of cancer makes β-glucans interesting candidates as adjuvants in antitumor therapies as well as in cancer prevention strategies. Here, the regulatory effects of dietary β-glucans on human innate immunity cells are reviewed and their potential role in cancer control is discussed.

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Section: In Vivo Effects In Cancer Patientsmentioning

confidence: 96%

Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer?

Cornò

Gessani

Conti

2020

Cancers

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“…The binding of lentinan, the β-glucan found in Lentinus edodes and in LEM, to CD14+ monocytes appeared to correlate with an improved quality of life as observed in patients with colorectal cancer [97]. Furthermore, an increase in total leukocyte count was found in patients with prostate adenocarcinoma who received carboxymethyl-glucan [100], and an increase in monocyte count was observed in breast cancer patients who received Imuneks β-glucan [101]. Besides changes in frequencies of immune cells, Imuneks also resulted in decreased levels of IL-4 and increased levels of IL-12 in serum from breast cancer patients, measured during two courses of chemotherapy [102].…”

Section: β-Glucans As Adjuvants To Anti-cancer Therapymentioning

confidence: 99%

Consumption of β-glucans to spice up T cell treatment of tumors: a review

Graaff

Govers

Wichers

et al. 2018

Expert Opinion on Biological Therapy

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Adoptive T-cell treatments of solid cancers have evolved into a robust therapy with objective response rates surpassing those of standardized treatments. Unfortunately, only a limited fraction of patients shows durable responses, which is considered to be due to a T cell-suppressive tumor microenvironment (TME). Here we argue that naturally occurring β-glucans can enable reversion of such T cell suppression by engaging innate immune cells and enhancing numbers and function of lymphocyte effectors. Areas covered: This review summarizes timely reports with respect to absorption, trafficking and immune stimulatory effects of β-glucans, particularly in relation to innate immune cells. Furthermore, we list effects toward well-being and immune functions in healthy subjects as well as cancer patients treated with orally administered β-glucans, extended with effects of β-glucan treatments in mouse cancer models. Expert opinion: Beta-glucans, when present in food and following uptake in the proximal gut, stimulate immune cells present in gut-associated lymphoid tissue and initiate highly conserved pro-inflammatory pathways. When tested in mouse cancer models, β-glucans result in better control of tumor growth and shift the TME toward a T cell-sensitive environment. Along these lines, we advocate that intake of β-glucans provides an accessible and immune-potentiating adjuvant when combined with adoptive T-cell treatments of cancer.

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“…Glucans, especially β-glucan, belong to the most studied immunomodulators both generally, and in the field of the pharmacological modulation of radiation damage. β-glucans are known as cell wall constituents of bacteria [ 9 ], yeast [ 10 ], fungi [ 11 ], and plants [ 12 ]. Early hematological studies have revealed that β-glucan stimulates proliferation of non-irradiated mouse pluripotent stem cells, as well as of several hematopoietic progenitor cell lineages, namely those of granulocytes, granulocytes/macrophages, macrophages, and erythrocytes e.g., [ 13 ].…”

Section: Immunomodulatorsmentioning

confidence: 99%

Pharmacological Modulation of Radiation Damage. Does It Exist a Chance for Other Substances than Hematopoietic Growth Factors and Cytokines?

Höfer

Hoferová

Falk

2017

IJMS

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In recent times, cytokines and hematopoietic growth factors have been at the center of attention for many researchers trying to establish pharmacological therapeutic procedures for the treatment of radiation accident victims. Two granulocyte colony-stimulating factor-based radiation countermeasures have been approved for the treatment of the hematopoietic acute radiation syndrome. However, at the same time, many different substances with varying effects have been tested in animal studies as potential radioprotectors and mitigators of radiation damage. A wide spectrum of these substances has been studied, comprising various immunomodulators, prostaglandins, inhibitors of prostaglandin synthesis, agonists of adenosine cell receptors, herbal extracts, flavonoids, vitamins, and others. These agents are often effective, relatively non-toxic, and cheap. This review summarizes the results of animal experiments, which show the potential for some of these untraditional or new radiation countermeasures to become a part of therapeutic procedures applicable in patients with the acute radiation syndrome. The authors consider β-glucan, 5-AED (5-androstenediol), meloxicam, γ-tocotrienol, genistein, IB-MECA (N6-(3-iodobezyl)adenosine-5’-N-methyluronamide), Ex-RAD (4-carboxystyryl-4-chlorobenzylsulfone), and entolimod the most promising agents, with regards to their contingent use in clinical practice.

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Effects of carboxymethyl-glucan from Saccharomyces cerevisiae on the peripheral blood cells of patients with advanced prostate cancer

Cited by 15 publications

References 17 publications

Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer?

Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer?

Consumption of β-glucans to spice up T cell treatment of tumors: a review

Pharmacological Modulation of Radiation Damage. Does It Exist a Chance for Other Substances than Hematopoietic Growth Factors and Cytokines?

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