Effects of carbon nanotubes on primary neurons and glial cells

Belyanskaya, Larisa; Weigel, Stefan; Hirsch, Cordula; Tobler, Ursina; Krug, Harald F.; Wick, Peter

doi:10.1016/j.neuro.2009.05.005

Cited by 169 publications

(130 citation statements)

References 54 publications

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“…15 (spherical) [6] 5-30 (width) [1][2][3][4] 24nm (hydrodynamic diameter) [7] 168 ± 13 [8] 20 (width) [5] 100 (width) [1][2][3][4] Core-size (nm) (DLS)…”

Section: Diameter (Nm) (Dls/tem/xdc)mentioning

confidence: 99%

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“…15 (spherical) [6] 5-30 (width) [1][2][3][4] 24nm (hydrodynamic diameter) [7] 168 ± 13 [8] 20 (width) [5] 100 (width) [1][2][3][4] Core-size (nm) (DLS)…”

Section: Diameter (Nm) (Dls/tem/xdc)mentioning

confidence: 99%

“…The specific methodology used to determine each property stated is detailed in the specific references provided [1][2][3][4][5][6][7][8] . 1-10…”

mentioning

confidence: 99%

Can the Ames test provide an insight into nano-object mutagenicity? Investigating the interaction between nano-objects and bacteria

et al. 2012

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“…When exposed to neuroblast-glioma cells in vitro, SWCNT induced DNA damage and cytotoxicity (Belyanskaya, Weigel et al 2009). Also SWCNT induced oxidative stress, cell membrane damage and DNA damage in neuronal pc12 cells (Zhang, Ali et al 2010).…”

Section: Neuronal Exposurementioning

confidence: 99%

Biological Activities of Carbon Nanotubes

Mishra¹,

Rojanasakul²,

Wang³

2012

The Delivery of Nanoparticles

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“…CNTs are hollow cylinders made of graphene sheets rolled in on themselves to form a tube [6]. They are categorized based on the number of carbon layers assembled together: single-walled (SW-CNTs), double-walled (DW-CNTs), and multi-walled (MW-CNTs) [7].…”

Section: Introductionmentioning

confidence: 99%

Glia and gliotransmitters on carbon nanotubes

Min

Yoon

2017

Nano Reviews & Experiments

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Introduction: Functionalised carbon nanotubes (CNTs) have been shown to be promising biomaterials in neural systems, such as CNT -based nerve scaffolds to drive nerve regeneration. CNTs have been shown to modulate neuronal growth and improve electrical conductivity of neurons.Methods: Cultured astrocytes on the functionalized CNTs (PEG, caroboxyl group) were assessed for distribution of GABA, glutamate uptake assay using isotope and change of conductance of CNTs by ATP. Immunostaining of GABA using anti-GABA (red), anti-GFAP (green) antibody in primary cortical astrocytes on MW-CNT and PDL coverslips.Results: The functionalization of CNTs has improved their solubility and biocompatibility and alters their cellular interaction pathways. Recently, CNTs have been shown to modulate morphofunctional characteristics of glia as well as neurons. Among the various types of glia, astrocytes express diverse receptors for corresponding neurotransmitters and release gliotransmitters, including glutamate, adenosine triphosphate, and γ-amino butyric acid. Gliotransmitters are primarily released from astrocytes and play important roles in glia–neuron crosstalk.Conclusion: This review focuses on the effects of CNTs on glial cells and discusses how functionalized CNTs can modulate morphology and gliotransmitters of glial cells. Based on exciting new findings, they look to be a promising material for use in brain disease therapy or neuroprosthetics.

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Effects of carbon nanotubes on primary neurons and glial cells

Cited by 169 publications

References 54 publications

Can the Ames test provide an insight into nano-object mutagenicity? Investigating the interaction between nano-objects and bacteria

Can the Ames test provide an insight into nano-object mutagenicity? Investigating the interaction between nano-objects and bacteria

Biological Activities of Carbon Nanotubes

Glia and gliotransmitters on carbon nanotubes

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