Effects of Carbon Dioxide Arterial Infusion on Hepatic Biochemistry and Histology in a Rabbit Model

Mladinich, Christopher R.J.; Hawkins, Irvin F.; Heaton-jones, Terrell G.; Shiroma, Jonathan T.; Weingarten, Karl E.; Kiehl, Anita R.; Mays, M. B. Calderwood; Kublis, Paul

doi:10.1097/00004424-199503000-00010

Cited by 7 publications

(4 citation statements)

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“…A rabbit study demonstrated no significant hepatic toxicity [28]. Early in our experience, we were fearful that CO 2 cerebral injections or reflux into the cerebral circulation may cause neurotoxicity.…”

Section: Safetymentioning

confidence: 91%

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Carbon dioxide (CO 2 ) digital subtraction angiography: 26-year experience at the University of Florida

1998

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Although the vascular system is presently being imaged by multiple high technology modalities, contrast angiography continues to be the gold standard; however, severe complications rarely occur. During the last 25 years (in over 1400 patients), CO2 has proven to be extremely safe (no allergy or renal failure). However, it is imperative to understand CO2's physical properties and potential dangers. Recently, CO2 is being routinely utilized not only because of safety, but for detection of minute amounts of bleeding, better collateral filling, and for most interventional procedures since unlimited volumes of CO2 can be injected between the catheter and guidewire. Presently, safe, reliable and "user-friendly" delivery systems are now commercially available. CO2 DSA images are now nearly comparable to iodinated contrast, and improvement in DSA images are evolving, including "stacking" software.

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Section: Safetymentioning

confidence: 91%

“…Because of the possibility of neurotoxicity [28], the cerebral arterial circulation should never be exposed to CO 2 .…”

Section: Contraindicationsmentioning

confidence: 99%

Carbon dioxide (CO 2 ) digital subtraction angiography: 26-year experience at the University of Florida

1998

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“…Thus, the CO 2 gas was injected at a dose of 12.6-16.2 ml/kg without severe complications, although hepatic isozymes were not measured. A previous report described a rabbit experimental model of intra-arterial CO 2 gas injection at a dose of 10 ml/kg in which no subacute hepatic adverse effects were observed (30).…”

Section: Discussionmentioning

confidence: 99%

Intra-arterially infused carbon dioxide-saturated solution for sensitizing the anticancer effect of cisplatin in a rabbit VX2 liver tumor model

Katayama

Sugimoto

Okada

et al. 2017

International Journal of Oncology

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The present study aimed to evaluate the efficacy of an intra-arterially infused carbon dioxide (CO2)-saturated solution in sensitizing the anticancer effect of cisplatin in a rabbit VX2 liver tumor model. Forty VX2 liver tumor-bearing Japanese white rabbits were randomly divided into four groups and infused via the proper hepatic artery with a saline solution (control group), CO2-saturated solution (CO2 group), cisplatin solution (cisplatin group), or CO2-saturated solution and cisplatin solution (combined group). The tumor volume (TV) and the relative tumor volume (RTV), RTV = (TV on day 3 or 7)/(TV on day 0) x 100, were calculated using contrast-enhanced computed tomography. Hypoxia-inducible factor-1α (HIF‑1α) and carbonic anhydrase IX (CA IX) staining were used to evaluate cellular hypoxia. Cleaved caspase-3 and cleaved caspase-9 were analyzed to assess tumor apoptosis. The mean RTV on days 3 and 7 were 202.6±23.7 and 429.2±94.8%, respectively, in the control group; 172.2±38.1 and 376.5±61.1% in the CO2 group; 156.1±15.1 and 269.6±45.2% in the cisplatin group; and 118.3±28.1 and 210.3±55.1% in the combined group. RTV was significantly lower in the CO2 group than in the control group (day 3; P<0.05), and in the combined group than in the cisplatin group (days 3 and 7; P<0.05). HIF-1α and CA IX suppression, and increased cleaved caspase-3 and cleaved caspase-9 expression, were detected in the CO2 and combined groups, compared with the other two groups. An intra-arterially infused CO2-saturated solution inhibits liver VX2 tumor growth and sensitizes the anticancer effect of cisplatin.

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“…In order to obtain optimal portal venograms in the procedure of CO 2 wedged hepatic venous portography, a single end-hole angiographic catheter is generally placed in the peripheral part and close to the liver capsule. Mladinich et al [23] reported the evaluation of CO 2 arterial infusion in a rabbit model and demonstrated no CO 2 -related histopathologic damages and no long-term effect on hepatic biochemistry. Semba et al [20] and Taylor et al [21] reported hepatic laceration and peritoneal extravasation related to the procedure of CO 2 wedged hepatic venography, even with the result of fatality.…”

Section: Discussionmentioning

confidence: 99%

Fine-needle percutaneous transhepatic parenchymal portal venography by using carbon dioxide: a pilot study in pigs

et al. 2003

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Our purpose was to evaluate the feasibility and safety of carbon dioxide (CO 2 ) in fine-needle percutaneous transhepatic parenchymal portal venography and its potential clinical applications. Three Belgian landrace pigs received fine-needle percutaneous transhepatic parenchymal portal venography by using CO 2 as a contrast agent. Under fluoroscopic and B-mode ultrasonic guidance, right or left lobe of liver was punctured with a 22-G Chiba needle, through which CO 2 was injected with a dedicated CO 2 injector at injection rate of 20 ml/s for 20 ml, 40 ml/s for 40 ml, 40 ml/s for 60 ml, and 40 ml/s for 80 ml, respectively. The portal venograms were obtained by use of digital subtraction angiography (DSA) system with animal in supine position. In one pig transarterial portal venography was per-formed, in addition, using iodinated contrast agent. The portal vein was visualized in each run of venography. Optimal images of portal tree structure up to four-order branches were obtained in all those with CO 2 injection rate of 40 ml/s, which appeared much better in quality than those obtained by cranial mesenteric arteriography with iodinated contrast agent. No extravasation of CO 2 , liver laceration, or any other complication occurred during the procedures. The technique we proposed demonstrated optimal portography, which appeared to be safe, minimally invasive, less time-consuming, cost-effective, and easy to perform, with great potential in clinical applications.

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Effects of Carbon Dioxide Arterial Infusion on Hepatic Biochemistry and Histology in a Rabbit Model

Cited by 7 publications

References 0 publications

Carbon dioxide (CO 2 ) digital subtraction angiography: 26-year experience at the University of Florida

Carbon dioxide (CO 2 ) digital subtraction angiography: 26-year experience at the University of Florida

Intra-arterially infused carbon dioxide-saturated solution for sensitizing the anticancer effect of cisplatin in a rabbit VX2 liver tumor model

Fine-needle percutaneous transhepatic parenchymal portal venography by using carbon dioxide: a pilot study in pigs

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