Effects of Carbogen on Cochlear Blood Flow and Hearing Function Following Acute Acoustic Trauma in Guinea Pigs

Zhao, Jing; Sun, Jiayu; Yang, Liu

doi:10.1016/j.arcmed.2012.10.003

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…Mechanistically, the intense metabolic activity induced by noise stimulation may make hair cells undergo oxidative stress, resulting in the cell death leading to noise-induced hearing loss (NIHL). In addition, blood flow in the cochlea has been well known as an critical factor for hearing function, and vasoconstriction induced by noise clearly contributes to NIHL [ 2 – 4 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Yang Mi Ryung® Extract on Noise‐Induced Hearing Loss in Mice

Kim

Kwak

Baek

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Noise-induced hearing loss (NIHL) results from the damage of the delicate hair cells inside the ear after excessive stimulation of noise. Unlike certain lower animals such as amphibians, fishes, and birds, in humans, hair cells cannot be regenerated once they are killed or damaged; thus, there are no therapeutic options to cure NIHL. Therefore, it is more important to protect hair cells from the noise before the damage occurs. In this study, we report the protective effect of Yang Mi Ryung extract (YMRE) against NIHL; this novel therapeutic property of YMRE has not been reported previously. Our data demonstrates that the hearing ability damaged by noise is markedly restored in mice preadministrated with YMRE before noise exposure, to the level of normal control group. Our study also provides the molecular mechanism underlying the protective effect of YMRE against NIHL by showing that YMRE significantly blocks noise-induced apoptotic cell death and reduces reactive oxygen species (ROS) production in cochleae. Moreover, quantitative polymerase chain reaction (qPCR) analysis demonstrates that YMRE has anti-inflammatory properties, suppressing the mRNA levels of TNFα and IL-1β induced by noise exposure. In conclusion, YMRE could be a useful preventive intervention to prevent hearing impairment induced by the exposure to excessive noise.

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Section: Introductionmentioning

confidence: 99%