Effects of Carbamazepine/Oxycodone Coadministration in the Treatment of Trigeminal Neuralgia

Abstract

Treatment with a combination of carbamazepine, a sodium channel blocker, and oxycodone, a mixed κ- and μ-opioid receptor agonist, may be useful in alleviating symptoms of trigeminal neuralgia.

B vitamins relieve neuropathic pain behaviors induced by infraorbital nerve constriction in rats

“…Currently, anticonvulsant drugs are commonly used to control symptoms in neuropathic pain, especially for their ability to reduce neuronal excitability by acting through different mechanisms (Attal et al, 2010;Delzell and Grelle, 1999;Finnerup et al, 2010aFinnerup et al, , 2010bGill et al, 2011;Martin and Forouzanfar, 2011;Willimann, 2011;Zakrzewska and McMillan, 2011). The most studied agents are carbamazepine, gabapentin and pregabalin, but lamotrigine, topiramate and oxcarbazepine have also shown analgesic potential in different pain models and in clinical studies (Ambrósio et al, 2002;Cheng and Chiou, 2006;Cheshire, 2002;Czapinski et al, 2005;Lynch and Watson, 2006;Siniscalchi et al, 2011;Wilhelmus and Forouzanfar, 2011). Indeed, carbamazepine is currently the first choice for treatment of trigeminal neuralgia, as it has been shown to reduce pain symptoms in about 70% of the cases, and it is also used to diagnose the condition (Ambrósio et al, 2002;Kleef et al, 2009).…”

Manejo del dolor en el síndrome de Guillain-Barré. Revisión sistemática

“…Tal es el caso de la combinación de pregabalina y oxicodona, que ha mostrado resultados favorables en el control del dolor neuropático tanto oncológico como no oncológico, como se evidencia en el estudio prospectivo aleatorizado realizado por Garassino et al 36 , el reporte de un caso con cáncer de pulmón y exacerbación de una ciática publicado por Baba y Gomwo 37 , y el estudio prospectivo realizado por Gatti et al 38 . La combinación de carbamazepina y oxicodona consiguió una resolución completa del dolor secundario a neuralgia del trigémino en un reporte de caso publicado por Siniscalchi et al 39 . Carbamazepina podría potenciar el efecto analgésico de la morfina en modelos de ratas con dolor posoperatorio, como lo demuestra el estudio realizado por Naseri et al 40 .…”

The serotonin transporter gene polymorphism is associated with the susceptibility and the pain severity in Idiopathic Trigeminal Neuralgia patients

“…TN is defined as sudden, usually unilateral, severe, brief, stabbing recurrent episodes of pain within the distribution of one or more branches of the trigeminal nerve [3,4]. carbamazepine (CBZ) is currently widely used for the treatment of TN, although treatment response varies among individual patient [5-8]. …”