Effects of carbamazepine in aquatic biota

Baali, Hugo; Cosio, Claudia

doi:10.1039/d1em00328c

Cited by 6 publications

(2 citation statements)

References 76 publications

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“…Gabapentin (Neurontin) and carbamazepine (Tegretol) are commonly detected in downstream urban freshwaters at maximum concentrations of up to 400 ng/L and 11,600 ng/L, respectively [ 14 , 32 ]. Our analysis revealed no alterations in spontaneous swimming activity or thermal preference behaviors in hatched zebrafish larvae after exposure to both gabapentin (400 ng/L) and carbamazepine (3000 ng/L) during embryogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…Urban wastewater treatment plants (WWTPs) are the main emitters of such pollutants into freshwater ecosystems [ 11 , 12 ]. Anticonvulsants, antidepressants, and psychostimulants are becoming pervasive micropollutants of urban waters since a majority of existing technologies are inadequate, providing a removal rate of less than 90% for most pharmaceuticals [ 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Sensory-Motor Perturbations in Larval Zebrafish (Danio rerio) Induced by Exposure to Low Levels of Neuroactive Micropollutants during Development

Henry

Bai

Kreuder

et al. 2022

IJMS

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Due to increasing numbers of anthropogenic chemicals with unknown neurotoxic properties, there is an increasing need for a paradigm shift toward rapid and higher throughput behavioral bioassays. In this work, we demonstrate application of a purpose-built high throughput multidimensional behavioral test battery on larval stages of Danio rerio (zebrafish) at 5 days post fertilization (dpf). The automated battery comprised of the established spontaneous swimming (SS), simulated predator response (SPR), larval photomotor response (LPR) assays as well as a new thermotaxis (TX) assay. We applied the novel system to characterize environmentally relevant concentrations of emerging pharmaceutical micropollutants including anticonvulsants (gabapentin: 400 ng/L; carbamazepine: 3000 ng/L), inflammatory drugs (ibuprofen: 9800 ng/L), and antidepressants (fluoxetine: 300 ng/L; venlafaxine: 2200 ng/L). The successful integration of the thermal preference assay into a multidimensional behavioral test battery provided means to reveal ibuprofen-induced perturbations of thermal preference behaviors upon exposure during embryogenesis. Moreover, we discovered that photomotor responses in larval stages of fish are also altered by the as yet understudied anticonvulsant gabapentin. Collectively our results demonstrate the utility of high-throughput multidimensional behavioral ecotoxicity test batteries in prioritizing emerging risks associated with neuroactive drugs that can perturb neurodevelopment. Moreover, we showcase the added value of thermotaxis bioassays for preliminary screening of emerging contaminants.

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Section: Discussionmentioning

confidence: 99%