Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A2 and inflammatory cytokines in patients referred for coronary angiography

Khandouzi, Nafiseh; Zahedmehr, Ali; Nasrollahzadeh, Javad

doi:10.1186/s12944-020-01362-z

Cited by 10 publications

(14 citation statements)

References 53 publications

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“…The LpPLA 2 activity taking under consideration the LDL levels (LpPLA 2 -to-LDL ratio) was lower after consumption of the yogurt enriched with PAF inhibitors from olive pomace compared to the plain yogurt at the end of the intervention. This finding is in accordance with other studies where dietary interventions resulted in reduced LpPLA 2 levels/activity [47][48][49]. In volunteers with metabolic syndrome red yeast rice olive supplementation is reported to inhibit in vivo LpPLA 2 activity [50].…”

Section: Discussionsupporting

confidence: 92%

Consumption of Enriched Yogurt with PAF Inhibitors from Olive Pomace Affects the Major Enzymes of PAF Metabolism: A Randomized, Double Blind, Three Arm Trial

et al. 2021

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Platelet-activating factor (PAF), a proinflammatory lipid mediator, plays a crucial role in the formation of the atherosclerotic plaque. Therefore, the inhibition of endothelium inflammation by nutraceuticals, such as PAF inhibitors, is a promising alternative for preventing cardiovascular diseases. The aim of the present study was to evaluate the impact of a new functional yogurt enriched with PAF inhibitors of natural origin from olive oil by-products on PAF metabolism. Ninety-two apparently healthy, but mainly overweight volunteers (35–65 years) were randomly allocated into three groups by block-randomization. The activities of PAF’s biosynthetic and catabolic enzymes were measured, specifically two isoforms of acetyl-CoA:lyso-PAF acetyltransferase (LPCATs), cytidine 5′-diphospho-choline:1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase (PAF-CPT) and two isoforms of platelet activating factor acetylhydrolase in leucocytes (PAF-AH) and plasma (lipoprotein associated phospholipase-A2, LpPLA2). The intake of the enriched yogurt resulted in reduced PAF-CPT and LpPLA2 activities. No difference was observed in the activities of the two isoforms of lyso PAF-AT. In conclusion, intake of yogurt enriched in PAF inhibitors could favorably modulate PAF biosynthetic and catabolic pathways.

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Section: Discussionsupporting

confidence: 92%

Consumption of Enriched Yogurt with PAF Inhibitors from Olive Pomace Affects the Major Enzymes of PAF Metabolism: A Randomized, Double Blind, Three Arm Trial

et al. 2021

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“…The publication year of the eligible studies was between 1988 and 2020. Of thirty-four trials, seventeen trials were performed on healthy participants (33–37,39,42–45,47,50,51,53,56,57,59) , three trials on those with peripheral or coronary vascular disease (28,32,41) , seven in patients with dyslipidemia (31,40,46,48,49,52,58) , two in patients with type 2 diabetes (29,60) , and one in patients with metabolic syndrome (30) , rheumatoid arthritis (38) , non-communicable disease (54) , non-alcoholic fatty liver disease (55) , and polycystic ovary syndrome (61) . Six trials were conducted in populations with overweight/obesity (37,45,55–57,61) , nine in those with normal weight (34,36,39,43,44,52,53,58,59) and the rest in mixed populations (28–31,32,33,35,38,40–42,46–51,54,60) .…”

Section: Resultsmentioning

confidence: 99%

“…In the control groups, participants received usual diet (31,32,44,54,57) or different oils including canola oil (29,41,45,46,51,52,61) , rapeseed oil (30,39,40,45,52,53) , sunflower oil (28,29,31,33,39,53,55,61) , maize oil (46,48,58) , flaxseed oil (43,50) , palm olein (34,35,59) , maize oil (46,58) , cocoa butter (34,59) , extra virgin coconut oil (42) , butter (42) , soyabean oil (37) , peanut oil (44) , sesame oil (49) , hybrid palm oil (47) , evening promise oil (38) and virgin argan oil (36) . There were five trials with usual diet as control group.…”

Section: Resultsmentioning

confidence: 99%

“…For the analysis of serum TC, thirty-one trials with 1574 participants were included in analysis (28–41,42,43,45–50,52–55,57–61) . For each 10 g/d increment in olive oil consumption, TC concentration slightly increased serum (MD: 0·79 mg/dl; 95 % CI (−0·08, 1·66); I 2 = 57 %, online Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-one trials with 1547 participants assessed the effect of olive oil intake on LDL-cholesterol (28–37,39–41,42–50,52–60) . Each 10 g/d increment in olive oil consumption decreased LDL-cholesterol by 0·04 mg/dl (95 % CI (−1·01, 0·94); I 2 = 80 %, online Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

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The effects of olive oil consumption on blood lipids: a systematic review and dose–response meta-analysis of randomised controlled trials

2022

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We performed a systematic review and dose-response meta-analysis of randomized trials on the effects of olive oil consumption on blood lipids in adults. A systematic search was performed in PubMed, Scopus, and Web of Science databases until May 2021. Randomized controlled trials (RCT) evaluating the effect of olive oil intake on serum total cholesterol (TC), triglyceride, low- (LDL-C) and high-density lipoprotein cholesterol (HDL-C) in adults were included. The mean difference (MD) and 95%CI were calculated for each 10 g/d increment in olive oil intake using a random effects model. A total of 34 RCTs with 1730 participants were included. Each 10 g/d increase in olive oil consumption had minimal effects on blood lipids including TC (MD: 0.79 mg/dL; 95%CI: -0.08, 1.66; I2=57%; n=31, GRADE=low certainty), LDL-C (MD: 0.04 mg/dL, %95CI: -1.01, 0.94; I2=80%; n=31, GRADE=very low certainty), HDL-C (MD: 0.22 mg/dL; %95CI: -0.01, 0.45; I2=38%; n=33, GRADE=low certainty), and triglycerides (MD: 0.39 mg/dL; 95%CI: -0.33, 1.11; I2=7%; n=32, GRADE=low certainty). Levels of TC increased slightly with the increase in olive oil consumption up to 30 g/d (MD30g/d: 2.76 mg/dL, 95%CI: 0.01, 5.51), and then appeared to plateau with a slight downward curve. A trivial nonlinear dose-dependent increment was seen for HDL-C, with the greatest increment at 20 g/d (MD20g/d: 1.03 mg/dL, 95%CI: -1.23, 3.29). Based on existing evidence, olive oil consumption had trivial effects on levels of serum lipids in adults. More large-scale randomized trials are needed to present more reliable results.

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Effects of diets rich in ghee or olive oil on cardiometabolic risk factors in healthy adults: a two-period, crossover, randomised trial

Hosseinabadi

Nasrollahzadeh

2021

Br J Nutr

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This study aimed to evaluate the cardiovascular health-related effects of consuming ghee in the usual diet. Thirty healthy men and women were studied in a free-living outpatient regimen. The participants were instructed for the isocaloric inclusion of ghee or olive oil in their diets for 4 weeks using a randomized crossover design. At the end of run-in (baseline), 2-week wash-out, and interventions, fasting blood samples were drawn. In addition, 2-h postprandial blood samples were collected after ingestion of a meal containing olive oil or ghee at week 4 of each dietary intervention. Body weight was not different between the two interventions. Compared to the olive oil, the diet with ghee increased fasting plasma apolipoprotein-B (apo B) (0.09, 95% CI 0.02 to 0.17 g/L, p= 0.018) and non-high-density lipoprotein cholesterol (non-HDL-C) (0.53, 95% CI 0.01 to 1.05 mmol/L, p= 0.046) and low-density lipoprotein cholesterol did not differ significantly between diet groups (0.29, 95% CI –0.05 to 0.63 mmol/L, p= 0.092), but had no significant effect on total cholesterol/HDL-C ratio (0.75, 95% CI −0.24 to 1.74 mmol/L, p= 0.118). No significant difference was observed in fasting as well as 2-h postprandial plasma triacylglycerol, glucose, insulin, and plasminogen activator inhibitor-1 concentrations. This study showed that ghee which is predominantly saturated fats had an increasing effect on plasma apo B and non-HDL-C compared to olive oil, adding further evidence to the existing recommendations to replace dietary fats high in SFA with dietary fats high in unsaturated fats to reduce cardiovascular disease risk.

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Effects of canola or olive oil on plasma lipids, lipoprotein-associated phospholipase A2 and inflammatory cytokines in patients referred for coronary angiography

Cited by 10 publications

References 53 publications

Consumption of Enriched Yogurt with PAF Inhibitors from Olive Pomace Affects the Major Enzymes of PAF Metabolism: A Randomized, Double Blind, Three Arm Trial

Consumption of Enriched Yogurt with PAF Inhibitors from Olive Pomace Affects the Major Enzymes of PAF Metabolism: A Randomized, Double Blind, Three Arm Trial

The effects of olive oil consumption on blood lipids: a systematic review and dose–response meta-analysis of randomised controlled trials

Effects of diets rich in ghee or olive oil on cardiometabolic risk factors in healthy adults: a two-period, crossover, randomised trial

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