Effects of cannabis use on age at onset in schizophrenia and bipolar disorder

Hert, Marc De; Wampers, Martien; Jendričko, Tihana; Franić, Tomislav; Vidović, Domagoj; Vriendt, N. De; Sweers, Kim; Peuskens, Joseph; Winkel, Ruud van

doi:10.1016/j.schres.2010.07.003

Cited by 82 publications

(51 citation statements)

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“…Thus, regular cannabis use may render individuals gradually more sensitive to dopamine-induced perceptual and cognitive abnormalities (De Hert et al, 2011), Indeed, Henquet et al (2006 reported that while baseline cannabis use was significantly associated with mania symptoms at follow-up, a similar association between follow-up cannabis use and mania was not observed. This supports that the effects of cannabis use on manic symptoms may result from long term rather than acute exposure…”

Section: Potential Mechanisms Underlying the Association Between Cannmentioning

confidence: 99%

Cannabis use and mania symptoms: A systematic review and meta-analysis

Gibbs

Winsper

Marwaha

et al. 2015

Journal of Affective Disorders

173

121

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(2015) Cannabis use and mania symptoms : a systematic review and meta-analysis. Journal of Affective Disorders, Volume 171 . pp. 39-47. Permanent WRAP url:http://wrap.warwick.ac.uk/64733 Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work of researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-forprofit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. Publisher statement: NOTICE: this is the author's version of a work that was accepted for publication in Journal of Affective Disorders. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in http://dx.doi.org/10.1016/j.jad.2014.09.016 A note on versions:The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP url' above for details on accessing the published version and note that access may require a subscription. 2 Background: Whilst cannabis use appears to be a causal risk factor for the development of schizophrenia-related psychosis, associations with mania remain relatively unknown. This review aimed to examine the impact of cannabis use on the incidence of manic symptoms and on their occurrence in those with pre-existing bipolar disorder Methods: A systematic review of the scientific literature using the PRISMA guidelines.PsychINFO, Cochrane, Scopus, Embase and MEDLINE databases were searched for prospective studies.Results: Six articles met inclusion criteria. These sampled 2,391 individuals who had experienced mania symptoms. The mean length of follow up was 3.9 years.Studies support an association between cannabis use and the exacerbation of manic symptoms in those with previously diagnosed bipolar disorder. Furthermore, a meta-analysis of two studies suggests that cannabis use is associated with an approximately 3-fold (Odds Ratio: 2.97; 95% CI: 1.80 to 4.90) increased risk for the new onset of manic symptoms. Limitations:We were only able to identify a small number of studies of variable quality, thus our conclusions remain preliminary. Conclusions:Our findings whilst tentative, suggest that cannabis use may worsen the occurrence of manic symptoms i...

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Section: Potential Mechanisms Underlying the Association Between Cannmentioning

confidence: 99%

Cannabis use and mania symptoms: A systematic review and meta-analysis

Gibbs

Winsper

Marwaha

et al. 2015

Journal of Affective Disorders

173

121

View full text Add to dashboard Cite

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“…One of the factors associated with an earlier age at first psychotic episode is cannabis use (Buhler et al 2002 ;Veen et al 2004 ;Barnes et al 2006 ;Mauri et al 2006 ;Addington & Addington, 2007 ;González-Pinto et al 2008 ;Ongur et al 2009 ;Sugranyes et al 2009 ;Barrigon et al 2010 ;Foti et al 2010 ;Pelayo-Terán et al 2010 ;De Hert et al 2011 ;Large et al 2011). In a recent meta-analysis, the mean age at onset of psychosis was 2.70 years lower in cannabis users compared to non-users (Large et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Age at onset of non-affective psychosis in relation to cannabis use, other drug use and gender

et al. 2012

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Background. Cannabis use is associated with an earlier age at onset of psychotic illness. The aim of the present study was to examine whether this association is confounded by gender or other substance use in a large cohort of patients with a non-affective psychotic disorder.Method. In 785 patients with a non-affective psychotic disorder, regression analysis was used to investigate the independent effects of gender, cannabis use and other drug use on age at onset of first psychosis.Results. Age at onset was 1.8 years earlier in cannabis users compared to non-users, controlling for gender and other possible confounders. Use of other drugs did not have an additional effect on age at onset when cannabis use was taken into account. In 63.5 % of cannabis-using patients, age at most intense cannabis use preceded the age at onset of first psychosis. In males, the mean age at onset was 1.3 years lower than in females, controlling for cannabis use and other confounders.Conclusions. Cannabis use and gender are independently associated with an earlier onset of psychotic illness. Our findings also suggest that cannabis use may precipitate psychosis. More research is needed to clarify the neurobiological factors that make people vulnerable to this precipitating effect of cannabis.

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“…In addition, the damage has to happen in specific stages of neurodevelopment. For example, a number of data indicate that substance abuse (particularly cannabis) during adolescence increases the risk of SCH and BD (De Hert et al 2011), while mothers' substance abuse during pregnancy may produce neurological syndromes in the future unborn, but it not certain the association with SCH and BD. Similarly, influenza epidemics in mothers increase the risk of SCH in offspring, but there is no effect of this virus in childhood or adolescence, while cytomegalovirus infections increase the risk of schizophrenia only if they happen during childhood (Brown 2011).…”

Section: Discussionmentioning

confidence: 99%