Effects Of Cannabidiol Supplementation On The Skeletal Muscle Regeneration After Intensive Resistance Training

Isenmann, Eduard; Veit, Sebastian; Diel, Patrick

doi:10.1249/01.mss.0000683540.93433.31

Cited by 8 publications

(12 citation statements)

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“…Regarding performance outcomes, a significant decrease was observed in 1RM but not in CMJ. The results of 1RM are confirmed with observations of previous studies [ 1 , 3 , 52 , 56 ]. However, the decrease in performance in the CBD group is smaller than that in the pilot study [ 52 ].…”

Section: Discussionsupporting

confidence: 91%

“…The results of 1RM are confirmed with observations of previous studies [ 1 , 3 , 52 , 56 ]. However, the decrease in performance in the CBD group is smaller than that in the pilot study [ 52 ]. This may be due to different performance levels of the subjects.…”

Section: Discussionsupporting

confidence: 91%

“…The results clearly show an increase in CK and Myo concentration in both groups at all time points (T24, T48, T72) with significant differences between the groups at T72 ( ES : CK = −0.24, Myo = −0.21). The exercise induced muscle damage and the increase in CK and Myo concentration after T24 confirms observations from previous studies [ 1 , 2 , 3 , 52 ]. However, a single supplementation of CBD did not reduce muscle damage within 48 h. A longer time interval of at least 72 h, however, might be sufficient for effects of CBD to occur to detectable extend.…”

Section: Discussionsupporting

confidence: 90%

“…However, a single supplementation of CBD did not reduce muscle damage within 48 h. A longer time interval of at least 72 h, however, might be sufficient for effects of CBD to occur to detectable extend. Therefore, this study cannot confirm the inhibitory effect of CBD on CK concentrations after 24 h as observed in a pilot project with very well-trained strength athletes [ 52 ]. Furthermore, it can be assumed that different nutritional supplements can promote recovery at different rates despite similar mechanisms.…”

Section: Discussionmentioning

confidence: 86%

“…In untrained males, the intake of CBD oil after six sets of ten maximal eccentric isokinetic elbow flexions did not result in any significant differences in perceived soreness, arm circumference, hanging joint angle, and peak torque between the groups [ 51 ]. In contrast, a pilot study [ 52 ] in highly trained men (>150% of body weight in the back squat [ 53 ]), showed an inhibitory effect of CBD on serum creatine kinase (CK) concentrations after three sets of 12 back squats at 70% 1RM plus three sets of 15 drop jumps landed in a deep squat. Consequently, based on the current lack of data, no definite conclusion can be drawn concerning the effects of CBD supplementation to promote regeneration processes after intensive strength training.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Cannabidiol Supplementation on Skeletal Muscle Regeneration after Intensive Resistance Training

et al. 2021

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Cannabidiol supplements (CBD) are increasingly consumed by athletes to improve regeneration. However, the evidence for the pro-regenerative effects of CBD in sports is quite limited. Therefore, our aim was to investigate the effects of a single CBD supplementation in a six-arm placebo-controlled crossover study after resistance training on performance and muscle damage. Before and after the resistance training, one-repetition maximum in the back squat (1RM BS), countermovement jump (CMJ), and blood serum concentrations of creatine kinase (CK) and myoglobin (Myo) were measured in healthy, well-trained participants. Sixteen of 21 participants completed the study and were included in the analysis. In 1RM BS, a significant decrease was observed after 24 h (p < 0.01) but not 48 or 72 h. A significant group difference was detected after 72 h (p < 0.05; ES = 0.371). In CMJ, no significant changes were observed. The CK and Myo concentrations increased significantly after 24 h (CK: p < 0.001; Myo: p < 0.01), 48 h (CK: p < 0.001; Myo: p < 0.01) and 72 h (CK: p < 0.001; Myo: p < 0.001). After 72 h, a significant group difference was observed in both muscle damage biomarkers (CK: p < 0.05 ES = 0.236; Myo: p < 0.05; ES = 0.214). The results show small and significant effects on muscle damage and recovery of squat performance after 72 h. However, more data are necessary for clearer statements about the pro-regenerative effects of CBD supplementation after resistance training.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Effects of Cannabidiol Supplementation on Skeletal Muscle Regeneration after Intensive Resistance Training

et al. 2021

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Does a broad‐spectrum cannabidiol supplement improve performance in a 10‐min cycle ergometer performance‐test?

Gillham,

Starke,

Welch

et al. 2024

European Journal of Sport Science

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Cannabidiol (CBD) is a non‐intoxicating phytocannabinoid which has been proposed to possess anti‐inflammatory and analgesic properties. Given the potential for perceptions of pain to limit exercise performance, the aim of the present study was to investigate if 3 weeks of daily CBD supplementation (150 mg day−1) improved performance in a 10‐min performance‐trial on a cycle ergometer. In a randomized, double‐blind and placebo‐controlled study, 22 healthy participants (n = 11 male and n = 11 female) completed two 10‐min performance trials on a WattBike cycle ergometer interspersed with a 3‐week supplementation period. Supplementation involved either 150 mg day−1 oral CBD or 150 mg day−1 of a visually identical placebo (PLA). During trials, ratings of perceived exertion (RPE [6–20]), heart rate (HR) and blood lactate (BLa) were collected every 2 min. Mean power (W) was also taken throughout the exercise at each time point. All data were analyzed using two‐way ANOVAs. There were no significant differences (P > 0.05) between CBD or PLA groups for mean power (W) during the 10‐min performance trial. There were also no significant differences (P > 0.05) in any of the physiological or perceptual parameters (HR, BLa and RPE) between conditions. Three weeks supplementation of a broad‐spectrum CBD supplement did not improve performance via any change in RPE during a 10‐min time trial on a cycle ergometer, and as such, this evidence does not support the claim that broad‐spectrum CBD supplements could be performance‐enhancing in this exercise modality.

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Cannabis and Athletic Performance

et al. 2021

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Cannabis is widely used for both recreational and medicinal purposes on a global scale. There is accumulating interest in the use of cannabis and its constituents for athletic recovery, and in some instances, performance. Amidst speculation of potential beneficial applications, the effects of cannabis and its two most abundant constituents, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), remain largely un-investigated. The purpose of this review is to critically evaluate the literature describing the effects of whole cannabis, THC, and CBD, on athletic performance and recovery. While investigations of whole cannabis and THC have generally shown either null or detrimental effects on exercise performance in strength and aerobic-type activities, studies of sufficient rigor and validity to conclusively declare ergogenic or ergolytic potential in athletes are lacking. The ability of cannabis and THC to perturb cardiovascular homeostasis warrants further investigation regarding mechanisms by which performance may be affected across different exercise modalities and energetic demands. In contrast to cannabis and THC, CBD has largely been scrutinized for its potential to aid in recovery. The beneficial effects of CBD on sleep quality, pain, and mild traumatic brain injury may be of particular interest to certain athletes. However, research in each of these respective areas has yet to be thoroughly investigated in athletic populations. Elucidating the effects of whole cannabis, THC, and CBD is pertinent for both researchers and practitioners given the widespread use of these products, and their potential to interact with athletes’ performance and recovery.

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Effects Of Cannabidiol Supplementation On The Skeletal Muscle Regeneration After Intensive Resistance Training

Cited by 8 publications

References 0 publications

Effects of Cannabidiol Supplementation on Skeletal Muscle Regeneration after Intensive Resistance Training

Effects of Cannabidiol Supplementation on Skeletal Muscle Regeneration after Intensive Resistance Training

Does a broad‐spectrum cannabidiol supplement improve performance in a 10‐min cycle ergometer performance‐test?

Cannabis and Athletic Performance

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