Effects of Cang-Ai volatile oil on depressed mood and cortical excitability in human

Wei, Yuanyuan; Cui, Jieqiong; Fu, Chenyang; Xu, Bonan; Shi, Mingqin; Dai, Youwu; Huang, Xin; Hai, Qingshan; Ni, Anqi; Chen, Bojun; Xiong, Lei; Qin, Dongdong

doi:10.1016/j.prmcm.2023.100215

Cited by 2 publications

(1 citation statement)

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“…In asthmatic mice, intragastric CAVO treatment significantly improves airway remodeling and inflammation, and suppresses the immune responses dominated by alveolar macrophages ( Yu, 2023 ). Functional near-infrared spectroscopy was used to show that inhaling CAVO alleviates depression mood and cortical excitability ( Wei et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Cang-ai volatile oil alleviates nasal inflammation via Th1/Th2 cell imbalance regulation in a rat model of ovalbumin-induced allergic rhinitis

Zhou,

Chen,

et al. 2024

Front. Pharmacol.

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We previously revealed that Cang-ai volatile oil (CAVO) regulates T-cell activity, enhancing the immune response in people with chronic respiratory diseases. However, the effects of CAVO on allergic rhinitis (AR) have not been investigated. Herein, we established an ovalbumin (OVA)-induced AR rat model to determine these effects. Sprague–Dawley (SD) rats were exposed to OVA for 3 weeks. CAVO or loratadine (positive control) was given orally once daily for 2 weeks to OVA-exposed rats. Behavior modeling nasal allergies was observed. Nasal mucosa, serum, and spleen samples of AR rats were analyzed. CAVO treatment significantly reduced the number of nose rubs and sneezes, and ameliorated several hallmarks of nasal mucosa tissue remodeling: inflammation, eosinophilic infiltration, goblet cell metaplasia, and mast cell hyperplasia. CAVO administration markedly upregulated expressions of interferon-γ, interleukin (IL)-2, and IL-12, and downregulated expressions of serum tumor necrosis factor-α, IL-4, IL-5, IL-6, IL-13, immunoglobulin-E, and histamine. CAVO therapy also increased production of IFN-γ and T-helper type 1 (Th1)-specific T-box transcription factor (T-bet) of the cluster of differentiation-4+ T-cells in splenic lymphocytes, and protein and mRNA expressions of T-bet in nasal mucosa. In contrast, levels of the Th2 cytokine IL-4 and Th2-specific transcription factor GATA binding protein-3 were suppressed by CAVO. These cumulative findings demonstrate that CAVO therapy can alleviate AR by regulating the balance between Th1 and Th2 cells.

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Section: Introductionmentioning

confidence: 99%

Cang-ai volatile oil alleviates nasal inflammation via Th1/Th2 cell imbalance regulation in a rat model of ovalbumin-induced allergic rhinitis

Zhou,

Chen,

et al. 2024

Front. Pharmacol.

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Exploring the Therapeutic Potential of Terpenoids for Depression and Anxiety

Noor

2024

Chemistry & Biodiversity

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This review focus on the terpenoids as potential therapeutic agents for depression and anxiety disorders, which naturally found in a variety of plants and exhibit a wide range of biological activities. Among the terpenoids discussed in this review are α‐pinene, β‐caryophyllene, α‐phellandrene, limonene, β‐linalool, 1, 8‐cineole, β‐pinene, caryophyllene oxide, p‐cymene, and eugenol. All of these compounds have been studied extensively regarding their pharmacological properties, such as neuroprotective effect, anti‐inflammation, antibacterial, regulation of neurotransmitters and antioxidant effect. Preclinical evidence are reviewed to highlight their diverse mechanisms of action and therapeutic potential to support antidepressant and anxiolytic properties. Additionally, challenges and future directions are also discussed to emphasize therapeutic utility of terpenoids for mental health disorders. Overall, this review provides a promising role of terpenoids as novel therapeutic agents for depression and anxiety, with potential implications for the development of more effective and well‐tolerated treatments in the field of psychopharmacology.

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Effects of Cang-Ai volatile oil on depressed mood and cortical excitability in human

Cited by 2 publications

References 50 publications

Cang-ai volatile oil alleviates nasal inflammation via Th1/Th2 cell imbalance regulation in a rat model of ovalbumin-induced allergic rhinitis

Cang-ai volatile oil alleviates nasal inflammation via Th1/Th2 cell imbalance regulation in a rat model of ovalbumin-induced allergic rhinitis

Exploring the Therapeutic Potential of Terpenoids for Depression and Anxiety

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