Effects of Campomanesia xanthocarpa on biochemical, hematological and oxidative stress parameters in hypercholesterolemic patients

Klafke, Jonatas Zeni; Silva, Mariane Arnoldi da; Panigas, Tiago Facchini; Belli, Karlyse Claudino; Oliveira, Marileides Facco de; Barichello, Márcia Meister; Rigo, Flávia Karine; Rossato, Mateus; Santos, Adair R.S.; Pizzolatti, Moacir Geraldo; Ferreira, Juliano; Viecili, Paulo Ricardo Nazário

doi:10.1016/j.jep.2009.11.004

Cited by 60 publications

(44 citation statements)

References 28 publications

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“…Scientific studies with human beings showed that treatment with C. xanthocarpa reduced blood triglycerides and LDL levels in hypercholesterolemic individuals [10]. In addition to its effect on cholesterol levels, this plant showed potential anti-inflammatory because reduced oxidative stress in hypercholesterolemic patients improving the levels of NOx [11].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

et al. 2016

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Campomanesia xanthocarpa (Myrtaceae) is used in Brazilian traditional medicine against fever, diabetes, hypercholesteremic, obesity, and urinary diseases. In the present study, the compounds 2',6'-dihydroxy-3'-methyl-4'-metoxychalcone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone were identified for the first time in leaves of the C. xanthocarpa. These compounds and the hydroethanolic extract (HECX) significantly inhibited paw edema and reduced both leukocyte migration and the leakage of protein into the pleural cavity. No toxicity was detected by HECX in an acute toxicity test.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

et al. 2016

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“…Moreover, the plant is popularly used for weight loss and in the control of a number of conditions associated with obesity (Dickel et al, 2007). According to Klafke et al (2010), the treatment with encapsulated C. xanthocarpa reduced blood total cholesterol and LDL levels in hypercholesterolemic patients. Furthermore, the fruits of Campomanesia spp.…”

Section: Introductionmentioning

confidence: 99%

Genotoxic effects ofCampomanesia xanthocarpaextracts onAllium cepavegetal system

Pastori

Flôres

Boligon

et al. 2013

Pharmaceutical Biology

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Context: Campomanesia xanthocarpa Berg. (Myrtaceae), popularly known in Brazil as guabiroba, is a plant used as antidiarrheic, anti-inflammatory and antirheumatic agents, and in stomach and hepatic disorders. Objective: The antiproliferative and genotoxic effects of aqueous extracts and essential oil of C. xanthocarpa were evaluated. Materials and methods: Cytotoxicity and genotoxicity of the aqueous extracts (6 and 30 mg/mL) and essential oil (0.25%, v/v) obtained from leaves of C. xanthocarpa were evaluated using the Allium cepa L. (Amaryllidaceae) assay. Mitotic index was calculated as the percentage of dividing cells of total cells observed; chromosome abnormalities were observed and counted during cell division. Additionally, the composition of the essential oil and the quantification of the main compounds of the extracts were determined by gas chromatography/mass spectrometry and high performance liquid chromatography coupled with diode array detector, respectively. Results and discussion: Aqueous extracts (6 and 30 mg/mL) led to a reduction of 67.7% and 34.1% of the mitotic index, respectively, whereas the treatment with essential oil caused a 48.2% reduction in the mitotic index, when compared with negative control. Chromosomal mutations were observed and included anaphase bridges, delay chromosome, break chromosome, as well as metaphase with disorganized chromosomal and binuclear cells. The main compounds of the essential oil were b-caryophyllene (8.87%), viridiflorol (6.40%), spathulenol (5.16%), d-cadinene (4.92%), linalool (4.46%) and a-cadinol (4.25%). Gallic acid (3.19%), chlorogenic acid (1.04%), quercetin (2.97%) and rutin (4.82%) were identified in an aqueous extract (30 mg/mL). Conclusion: Our results demonstrated that genotoxic and antiproliferative activities are present in C. xanthocarpa infusions using the in vivo onion root-tip cell test.

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“…As aplicações testadas para bracatinga incluem ação antiviral contra a febre amarela (Ono et al, 2003) (Pereira et al, 2012), já foi descrita para redução dos níveis de colesterol no sangue (Klafke et al, 2010;Viecili et al, 2014). Os efeitos de extratos da guavirova foram investigados em ratos alimentados com dieta hipercalórica, sendo constatada redução significativa no ganho de peso, em comparação ao grupo controle (Biavatti et al, 2004).…”

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Potencial Terapêutico de Espécies Arbóreas em Fragmentos de Floresta Ombrófila Mista

et al. 2016

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RESUMOObjetivou-se levantar o potencial terapêutico de espécies arbóreas presentes em remanescentes de Floresta Ombrófila Mista (FOM) localizados no Planalto Sul Catarinense, destacando as que possuem ações terapêuticas atestadas em ensaios científicos, assim como, aquelas com potencial medicinal segundo registros etnobotânicos. Para amostrar a composição florística arbórea foi empregado o método de quadrantes, registrando-se os indivíduos mais próximos do ponto central, que apresentassem DAP ≥ 5 cm. A amostragem foi realizada em Áreas de Preservação Permanente (APP's) e/ou Reserva Legal, com o auxílio de 20 transecções contendo 20 pontos quadrantes cada, totalizando 2,61 hectares. Dentre as 97 espécies registradas e identificadas no levantamento, 16 possuem ação medicinal descrita e atestada em literatura e 12 espécies são descritas como potenciais de acordo com conceitos etnobotânicos. O presente estudo mostrou que pequenos remanescentes florestais podem contribuir para a manutenção de espécies da FOM e basear futuros estudos sobre plantas medicinais ou com outros potenciais bioativos.Palavras-chave: floresta com araucária, conservação florestal, etnobotânica. Therapeutic Potential of Tree Species in Araucaria Forest Fragments ABSTRACTThis study aimed to evaluate the medicinal potential of tree species in Araucaria Forest (FOM) remnants in Santa Catarina Plateau, highlighting those with therapeutic actions attested in scientific trials, as well as those with medicinal potential according to ethnobotanical records. The floristic composition was sampled through the point-centered quarter method, registering the individuals with DBH ≥ 5 cm closest to the center point. Sampling was conducted in Permanent Preservation Areas (APP's) and/or Legal Reserve, with the help of 20 transects with 20 points quadrants each, totaling 2.61 hectares. Among the species recorded and identified, 16 of them, classified into 13 plant families, have medicinal potential described and attested in literature and 12 species within 10 families, are suggested as potential, according to ethnobotanical concepts. The present study showed that these sites may contribute to the maintenance of species of FOM and to base future studies on medicinal plants and/or other bioactive potential.

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Effects of Campomanesia xanthocarpa on biochemical, hematological and oxidative stress parameters in hypercholesterolemic patients

Abstract: Confirming its popular use, the treatment with Campomanesia xanthocarpa encapsulated reduced blood TC and LDL levels in hypercholesterolemic patients.

Cited by 60 publications

References 28 publications

Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

Genotoxic effects ofCampomanesia xanthocarpaextracts onAllium cepavegetal system

Potencial Terapêutico de Espécies Arbóreas em Fragmentos de Floresta Ombrófila Mista

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