Effects of Camphor on Enzymes, Hormones and Liver Tissues of Male White Mice

doi:10.21608/asejaiqjsae.2017.4045

Cited by 2 publications

(2 citation statements)

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“…The value of FSH levels if > 10.36 mIU/ml has a sensitivity of 82.1% with a specificity of 79.5% for azoospermia [12]. Similar studies also found that increasing FSH levels could adversely affect the reproduction of male mice [30]. The American Society for Reproductive Medicine and Society for Male Reproduction and Urology found that an FSH level that is twice as high indicates spermatogenic failure [31].…”

Section: Effect Of Administration Of Ethanol Extract Of Marigold Leav...mentioning

confidence: 76%

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2023

J. Med. Chem. Sci.

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Cigarette smoke produces particles such as nicotine, tar, and cadmium which can damage male germ cells and interfere with the hypothalamus, pituitary, and testicles which cause spermatogenesis disorders. The study aimed to analyze the differences in FSH levels in each group of mice (Mus musculus) exposed to cigarette smoke by administering ethanol extract from marigold leaves (Tegetes erecta). The laboratory experimental research method used a Randomized post-test-only control group design with exposure to one cigarette smoke 1 cigarette per day and administration of ethanol extract of marigold leaves (Tegetes erecta). The grouping of research samples used simple random sampling in 5 groups with experimental mice (Mus Musculus) males aged 8-12 weeks and weighing 20-25 grams which were divided into 5 groups, namely K(-) (placebo), K(+) (smoked cigarettes and placebo), P1 (cigarette smoke and marigold leaf extract dose 0.25 g/kg-BW), P2 (smoked cigarettes and marigold leaf extract dose 0.50 g/kg-BW), and P3 (smoked cigarettes and marigold leaf extract dose 1, 0 g/kg-BW). FSH levels were examined using ELISA. The results of the analysis of examining FSH levels showed an average of K(-): 0.80 mIU/ml, K(+): 0.60 mIU/ml, P1: 0.54 mIU/ml (dose 0.25 g/kg-BW), P2:0.60 mIU/ml (dose of 0.50 g/kg-BW), and P3:0.55 mIU/ml (dose of 1.0 g/kg-BW) with p-value ≤0.05. In conclusion, there was a significant effect of the administration of ethanol extract of marigold leaves (Tegetes erecta) on the FSH levels of mice exposed to cigarette smoke.

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Section: Effect Of Administration Of Ethanol Extract Of Marigold Leav...mentioning

confidence: 76%

Untitled

2023

J. Med. Chem. Sci.

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“…Based on our gas-chromatographic studies, the likely reason for these elevated values is the high concentration of camphor. Several other studies have suggested liver damage associated with camphor intake, although the exact mechanism of its toxicity is not fully established [ 57 , 58 , 59 , 60 , 61 , 62 ]. On the other hand, hepatoprotective properties are attributed to certain other components of the EO.…”

Section: Resultsmentioning

confidence: 99%

A Study of the Chemical Composition, Acute and Subacute Toxicity of Bulgarian Tanacetum parthenium Essential Oil

Lechkova,

Karcheva-Bahchevanska,

Ivanov

et al. 2023

Molecules

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Background: Tanacetum parthenium (L.) Sch.Bip. (T. parthenium) is an aromatic perennial plant belonging to the Asteraceae family, also known as feverfew. It is widely distributed in various regions of Europe and other parts of the world. The plant has a rich background in the traditional medicine of many nations and has been used as a remedy for fever, pain, inflammation, asthma, rheumatism, menstrual disorders, etc. Methods: GC–MS analysis was conducted to determine the chemical composition of the isolated essential oil (EO). Using the method proposed by Litchfield and Wilcoxon, the average lethal dose (LD50) of the EO on Wistar rats was determined for two routes of administration: oral (p.o.) and intraperitoneal (i.p.). The subacute toxicity of the EO was also tested by oral administration of a daily dose of 1.0 g/kg body weight (BW) for 28 days. The toxicity of the EO was evaluated by observing and evaluating changes in behavior, body weight, basic hematological and serum biochemical parameters, and histopathological changes of the internal organs. Results: Thirty-seven volatile organic compounds representing 94.58% of the total oil composition were tentatively detected in the obtained T. parthenium EO. The dominant compounds were camphor (45.47%), trans-chrisantenyl acetate (21.65%), camphene (9.48%), and cis-isogeraniol (5.42%). The results showed that the EO was not toxic when administered in acute oral doses. The acute mean lethal dose for intraperitoneal administration was LD50 i.p. = 2.13 g/kg BW. In the subacute study involving administration of an oral dose of EO for 28 days, there were a number of changes in the hematological and serum biochemical parameters of the blood compared with the control group of animals. However, no symptoms of toxicity, changes in the body weight of the rats, death, or pathological changes in the histological indicators of the examined organs—brain, heart, stomach, liver, spleen and kidney—were found. Extrapolating the results obtained from the rat experiments, we can state that the EO is safe for use in doses below 1 g/kgBW for a period not exceeding one month.

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Effects of Camphor on Enzymes, Hormones and Liver Tissues of Male White Mice

Cited by 2 publications

References 7 publications

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A Study of the Chemical Composition, Acute and Subacute Toxicity of Bulgarian Tanacetum parthenium Essential Oil

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