Effects of Calorie Restriction on Preserving Male Fertility Particularly in a State of Obesity

Zafar, Mohammad Ishraq; Chen, Xiao

doi:10.1007/s13679-024-00557-0

Cited by 1 publication

(2 citation statements)

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“…CR can negatively impact sperm quality by inducing metabolic and hormonal changes. CR leads to a metabolic shift from glucose-dependent to lipid-dependent pathways, activating AMPK and inhibiting the mTOR pathway [ 122 ]. This metabolic alteration reduces protein synthesis and increases autophagy, which, while beneficial for cellular health, can impair spermatogenesis [ 122 ].…”

Section: Nutritional Impact On Hormonal Regulationmentioning

confidence: 99%

“…CR leads to a metabolic shift from glucose-dependent to lipid-dependent pathways, activating AMPK and inhibiting the mTOR pathway [ 122 ]. This metabolic alteration reduces protein synthesis and increases autophagy, which, while beneficial for cellular health, can impair spermatogenesis [ 122 ]. Additionally, CR influences the hormonal balance by increasing cortisol levels and altering the secretion of gonadotropins, which can disrupt the HPG axis [ 114 ].…”

Section: Nutritional Impact On Hormonal Regulationmentioning

confidence: 99%

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Obesity, Dietary Patterns, and Hormonal Balance Modulation: Gender-Specific Impacts

Mazza,

Troiano,

Ferro

et al. 2024

Nutrients

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Understanding the intricate relationship between nutrition, hormonal balance, and gender-specific factors is crucial for developing targeted interventions to mitigate obesity-related endocrine disruptions and improve metabolic health. This narrative review examines the impact of various dietary patterns on hormonal regulation in both men and women, focusing on their effects on hormonal balance and metabolic health in the context of obesity. Calorie restriction, the Western diet, high-fat diets, low-CHO diets, plant-based diets, and the Mediterranean diet are analyzed in relation to their influence on obesity-related endocrine disruptions and metabolic health. Future research directions include investigating the specific mechanisms underlying dietary influences on hormonal regulation, addressing the gender-specific metabolic differences and body fat distribution, and exploring the dietary needs of individuals undergoing gender transition. Personalized dietary interventions tailored to individual metabolic and hormonal profiles are essential for optimizing health outcomes across the gender spectrum. By integrating gender-specific considerations into dietary recommendations, healthcare professionals can better support individuals in achieving optimal metabolic health and hormonal balance.

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Section: Nutritional Impact On Hormonal Regulationmentioning

confidence: 99%