Effects of callosal lesions in a model of letter perception

Shevtsova, Natalia A.; Reggia, James A.

doi:10.3758/cabn.2.1.37

Cognitive, Affective, & Behavioral Neuroscience

2002

DOI: 10.3758/cabn.2.1.37

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Effects of callosal lesions in a model of letter perception

Natalia A. Shevtsova

James A. Reggia

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Cited by 2 publications

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References 47 publications

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“…This population of projection neurons connects homotopic areas of neocortex in opposite hemispheres, and, although their precise function has not been fully delineated, it has been suggested that these neurons participate in motor coordination (Bury and Jones, 2002;Gerloff and Andres, 2002;Rouiller et al, 1994) as well as higher associative and cognitive processes (Hasegawa et al, 1998;Hampel et al, 2002;Kennedy and Dehay, 1988;Larson et al, 2002;Shevtsova and Reggia, 2002).…”

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Large‐scale maintenance of dual projections by callosal and frontal cortical projection neurons in adult mice

Mitchell

Macklis

2004

J of Comparative Neurology

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Integration of sensory-motor information in premotor cortex of rodents occurs largely through callosal and frontal cortical association projections directed in a hierarchically organized manner. Although most anatomical studies in rodents have been performed in rats, mammalian genetic models have focused on mice, because of their successful manipulation on the genetic and cell biological levels. It is therefore important to establish the normal patterns of anatomical connectivity in mice, which potentially differ from those in rats. The goal of this study is to investigate the anatomical development of callosal and frontal premotor projection neurons (CPN and FPN, respectively) in mouse sensory-motor and premotor cortex and to investigate quantitatively the potential laminar differences between these neurons with simultaneous callosal and frontal projections during development. The retrograde tracers Fluoro-Gold and DiI were injected into sensory-motor and premotor cortices, respectively, C57Bl/6 mice at different developmental times (P2, P8, P21, adult). We found that, in contrast to the case in primate and cat, there is widespread overlap in populations of long-distance projection neurons in mice; many projection neurons have simultaneous projections to both contralateral somatosensory cortex and ipsilateral frontal cortex, and a considerable number of these dual projections persist into adulthood. In addition, there are significant laminar differences in the percentage of neurons with simultaneous callosal and frontal projections, and an isolated population of layer V FPN has bilateral projections to both premotor cortical hemispheres. Taken together, our results indicate that a large proportion of individual projection neurons maintains simultaneous callosal and frontal projections in adult mice, suggesting that these dual projections might serve the critical function of integrating motor coordination information with multimodal association areas.

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Large‐scale maintenance of dual projections by callosal and frontal cortical projection neurons in adult mice

Mitchell

Macklis

2004

J of Comparative Neurology

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“…The largest collection of these tracts comprises the corpus callosum (CC), a structure bridging the two cortical hemispheres and providing interhemispheric communication essential for cognitive and associative processes12, as well as several higher-order sensory and motor functions345678.…”

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Proteome dynamics during postnatal mouse corpus callosum development

Son

Suto

et al. 2017

Sci Rep

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Formation of cortical connections requires the precise coordination of numerous discrete phases. This is particularly significant with regard to the corpus callosum, whose development undergoes several dynamic stages including the crossing of axon projections, elimination of exuberant projections, and myelination of established tracts. To comprehensively characterize the molecular events in this dynamic process, we set to determine the distinct temporal expression of proteins regulating the formation of the corpus callosum and their respective developmental functions. Mass spectrometry-based proteomic profiling was performed on early postnatal mouse corpus callosi, for which limited evidence has been obtained previously, using stable isotope of labeled amino acids in mammals (SILAM). The analyzed corpus callosi had distinct proteomic profiles depending on age, indicating rapid progression of specific molecular events during this period. The proteomic profiles were then segregated into five separate clusters, each with distinct trajectories relevant to their intended developmental functions. Our analysis both confirms many previously-identified proteins in aspects of corpus callosum development, and identifies new candidates in understudied areas of development including callosal axon refinement. We present a valuable resource for identifying new proteins integral to corpus callosum development that will provide new insights into the development and diseases afflicting this structure.

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Effects of callosal lesions in a model of letter perception

Cited by 2 publications

References 47 publications

Large‐scale maintenance of dual projections by callosal and frontal cortical projection neurons in adult mice

Large‐scale maintenance of dual projections by callosal and frontal cortical projection neurons in adult mice

Proteome dynamics during postnatal mouse corpus callosum development

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