Effects of Calcium Gluconate, a Water Soluble Calcium Salt on the Collagen-Induced DBA/1J Mice Rheumatoid Arthritis

Sohn, Ki Cheul; Kang, Su Jin; Kim, Joo Wan; Kim, Ki Young; Ku, Sae Kwang; Lee, Young Joon

doi:10.4062/biomolther.2013.040

Cited by 9 publications

(5 citation statements)

References 34 publications

(43 reference statements)

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“…Previous studies have found that dietary calcium supplementation can prevent osteoporosis and osteoarthritis in vivo 32,33 . In addition, it has been found that calcium gluconate had favorable effects on Collagen‐induced arthritis (CIA) mice, which were mediated by its anti‐inflammatory, anti‐oxidative, and immunomodulatory properties 9 . Nevertheless, the effect of calcium on osteoclastogenesis and bone resorption was not mentioned.…”

Section: Discussionmentioning

confidence: 99%

“…32,33 In addition, it has been found that calcium gluconate had favorable effects on Collageninduced arthritis (CIA) mice, which were mediated by its anti-inflammatory, anti-oxidative, and immunomodulatory properties. 9 Nevertheless, the effect of calcium on osteoclastogenesis and bone resorption was not mentioned. Besides synovial inflammation, joint bone erosion is another apparent characteristic of RA.…”

Section: Discussionmentioning

confidence: 99%

“…A randomized clinical trial indicated that an increased calcium intake has a significant impact on bone accretion in children with juvenile RA 8 . Moreover, an experimental study in vivo found that calcium gluconate, a kind of water‐soluble calcium salt, suppressed the production of IL‐6 and TNFα, and reduced the local inflammatory response in collagen‐induced arthritis (CIA) mice 9 . However, the role of calcium and the molecular mechanisms of its action in the development of RA has not been clearly identified.…”

Section: Introductionmentioning

confidence: 99%

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A rescue diet raises the plasma calcium concentration and ameliorates rheumatoid arthritis in mice: Role of CaSR ‐mediated inhibition of osteoclastogenesis

Yang

Zhao

et al. 2022

The FASEB Journal

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Calcium modulates bone cell recruitment, differentiation, and function by binding to the calcium‐sensing receptor (CaSR). However, the function of CaSR induced by high extracellular calcium (Ca2+e) in the regulation of osteoclast formation in rheumatoid arthritis (RA) remains unknown. Here, we used TNFα‐transgenic (TNFTG) RA mice and their wildtype (WT) littermates fed a normal or a rescue diet (high calcium, high phosphorus, and high lactose diet, termed rescue diet) to compare their joint bone phenotypes. In comparison to TNFTG mice fed the normal diet, articular bone volume and cartilage area are increased, whereas inflamed area, eroded surface, TRAP+ surface, and osteoclast‐related genes expression are decreased in TNFTG mice fed the rescue diet. Besides, TNFTG mice fed the rescue diet were found to exhibit more CaSR+ area and less NFATc1+/TRAP+ area. Furthermore, at normal Ca2+e concentrations, osteoclast precursors (OCPs) from TNFTG mice formed more osteoclasts than OCPs from WT mice, but the number of osteoclasts gradually decreased when the Ca2+e concentration increased. Meanwhile, the expression of CaSR increased responding to a high level of Ca2+e, whereas the expression of NF‐κB/NFATc1 signaling molecules decreased. At last, the knockdown of CaSR blocked the inhibition of osteoclast differentiation attributed to high Ca2+e. Taken together, our findings indicate that high Ca2+e inhibits osteoclast differentiation in RA mice partially through the CaSR/NF‐κB/NFATc1 pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A rescue diet raises the plasma calcium concentration and ameliorates rheumatoid arthritis in mice: Role of CaSR ‐mediated inhibition of osteoclastogenesis

Yang

Zhao

et al. 2022

The FASEB Journal

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“…In another study, calcium gluconate has been reported to produce pancreatitis in cats. 8 Current study was aimed at answering a few important questions and issues. If calcium is able to enhance effect of etoricoxib as it has been shown to enhance nonselective NSAID, aspirin, it might be possible to use calcium to enhance anti-inflammatory effect of etoricoxib.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the effect of calcium on the anti-inflammatory activity of etoricoxib in albino rats

Naringrekar¹,

Mamtora²

2021

Int J Basic Clin Pharmacol

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Background: It would be worthwhile to investigate if it is possible to obtain an anti-inflammatory effect with a lower dose of etoricoxib after it has been combined with calcium, the effect of which is equivalent to higher dose of etoricoxib. Hence the aim was to study effect of calcium and calcium gluconate on the anti-inflammatory activity of etoricoxib.Methods: Animals were distributed in five groups each group containing six rats. Experiments were conducted between 9:00 to 16:00 hours. All animal procedures were performed in accordance with the recommendations for proper care and use of laboratory animal .The doses of drugs employed in the study were based upon the human dose after conversion to that of rat.Results: The results of present study indicate that calcium gluconate (50 mg/kg) combined with etoricoxib (5 mg/kg) possesses significant anti-inflammatory property both in acute and subacute models of inflammation which was comparable to that of etoricoxib (8 mg/kg).Conclusions: From the present study it is concluded that calcium gluconate (50 mg/kg) possesses an anti-inflammatory activity. Lower dose of etoricoxib (5 mg/kg) if combined with calcium gluconate (50 mg/kg) can produce significant anti-inflammatory effect. The advantages of such combined preparations are obviously a reduction in the dose of etoricoxib that could still produce significant anti-inflammatory action and a possible protection against COX -2 inhibitor induced prothrombotic events. It is worthwhile to evaluate such preparations through clinical trials.

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“…Calcium salts have been shown to exhibit anti-inflammatory activity [15,16,17]. The anti-inflammatory activity of calcium gluconate has been shown to enhance that of non-steroidal anti-inflammatory drugs [18], as well as to mitigate ligation-induced periodontitis and related alveolar bone loss [7] and collagen-induced rheumatoid arthritis [19] via anti-oxidant and anti-inflammatory mechanisms.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Topical Application of Polycal (a 2:98 (g/g) Mixture of Polycan and Calcium Gluconate) on Experimental Periodontitis and Alveolar Bone Loss in Rats

et al. 2016

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Abstract:The aim of this study was to observe whether Polycal has inhibitory activity on ligationinduced experimental periodontitis and related alveolar bone loss in rats following topical application to the gingival regions. One day after the ligation placements, Polycal (50, 25, and 12.5 mg/mL solutions at 200 µL/rat) was topically applied to the ligated gingival regions daily for 10 days. Changes in bodyweight, alveolar bone loss index, and total number of buccal gingival aerobic bacterial cells were monitored, and the anti-inflammatory effects were investigated via myeloperoxidase activity and levels of the pro-inflammatory cytokines IL-1β and TNF-α. The activities of inducible nitric oxide synthase (iNOS) and lipid peroxidation (MDA) were also evaluated. Bacterial proliferation, periodontitis, and alveolar bone loss induced by ligature placements were significantly inhibited after 10 days of continuous topical application of Polycal. These results indicate that topical application of Polycal has a significant inhibitory effect on periodontitis and related alveolar bone loss in rats mediated by antibacterial, anti-inflammatory, and anti-oxidative activities.

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Effects of Calcium Gluconate, a Water Soluble Calcium Salt on the Collagen-Induced DBA/1J Mice Rheumatoid Arthritis

Cited by 9 publications

References 34 publications

A rescue diet raises the plasma calcium concentration and ameliorates rheumatoid arthritis in mice: Role of CaSR ‐mediated inhibition of osteoclastogenesis

A rescue diet raises the plasma calcium concentration and ameliorates rheumatoid arthritis in mice: Role of CaSR ‐mediated inhibition of osteoclastogenesis

Assessment of the effect of calcium on the anti-inflammatory activity of etoricoxib in albino rats

The Effects of Topical Application of Polycal (a 2:98 (g/g) Mixture of Polycan and Calcium Gluconate) on Experimental Periodontitis and Alveolar Bone Loss in Rats

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