Effects of calcium and verapamil on vesicourethral smooth muscle of rabbits

Khanna, Om P.; Barbieri, E; Moss, Marc; Son, Daniel L.; McMichael, Robert

doi:10.1016/0090-4295(83)90088-2

Cited by 25 publications

(14 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These contractions have a requirement for calcium, which has been known for sometime. Khanna et al [1983] demonstrated that spontaneous detrusor contractions were abolished in calcium-deprived media. This ¢nding has been recon¢rmed recently in cultured human bladder smooth muscle cells [Chambers et al, 1996] in which the investigators demonstrated an increase in intracellular calcium produced byATP.…”

Section: Discussionmentioning

confidence: 98%

Differing effects of N^G‐monomethyl L‐arginine and 7‐nitroindazole on detrusor activity

Theobald

2002

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

Differing effects of N^G‐monomethyl L‐arginine and 7‐nitroindazole on detrusor activity

Theobald

2002

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

“…In urinary tract smooth muscle, nifedipine at 1 X 10~7 M has been shown to reduce the contractile re sponse of human bladder muscle strips to various stimuli [6]. Verapamil at similar con centrations has demonstrated the capacity to inhibit contractions of rabbit vesicourethral smooth muscle in a noncompetitive manner [7].…”

Section: Discussionmentioning

confidence: 99%

“…5). Recent investigations have revealed that the calcium antagonists verapamil and nifedipine can affect urinary tract smooth muscle in vivo and in vitro [6][7][8][9]; less is known with regard to the effect of diltiazem on this smooth muscle system.…”

mentioning

confidence: 99%

Effect of Diltiazem on in vitro Rabbit Bladder Function

Wein¹,

Brendler²,

Levin³

1985

Pharmacology

View full text Add to dashboard Cite

The relationship between extracellular calcium and urinary bladder function was investigated by studying the effect of the specific calcium antagonist diltiazem on the functional ability of the in vitro whole rabbit urinary bladder to empty in response to pharmacological stimulation. The bladder was found to require an extracellular calcium concentration of 4.5 × 10^–4M to elicit near complete cholinergic-mediated emptying. Diltiazem (1 × 10^–6–1 × 10^–4M) inhibition of bladder function was competitively antagonized by increasing the extracellular calcium concentration (0.45 × 10^–4–3.6 × 10^–4M). In the absence of diltiazem, alterations in the extracellular calcium concentration between 0.45 × 10^–4 and 3.6 × 10^–4M had no significant effects on bladder response to bethanechol.

show abstract

“…Norepinephrine and phenylephrine are both a-adrenergic agonists with (3-adrenergic agonist activities. i32-Adrenergic receptors are known to mediate relaxation of the detrusor muscle (15). Therefore, the contraction of the detrusor muscle induced by norepine phrine and phenylephrine was interfered by the relaxation due to their 3-adrenergic receptor activation.…”

mentioning

confidence: 99%

In vitro characterization of .ALPHA.-adrenergic receptor in rabbit detrusor muscle.

1987

View full text Add to dashboard Cite

Abstract-In the isolated detrusor smooth muscle of the rabbit urinary bladder, acetylcholine, prostaglandin (PG) F2a, histamine and methoxamine produced dose-dependent contractions. The order of efficacy was acetylcholine>PGF2a> histamine>methoxamine.Acetylcholine and oxotremorine increased tension remarkably in the rabbit detrusor muscle; and McN-A-343 also developed tension, but with weaker sensitivity and efficacy. The contractile response to acetylcholine was competitively antagonized by atropine (pA2 9.24) and pirenzepine (pA2 6.96), respectively. Histamine and 2-pyridylethylamine caused dose-dependent contractions. On the other hand, dimaprit caused no response in this tissue. Mepyramine (pA2 8.80) competitively antagonized the contraction induced by histamine, whereas cimetidine failed to antagonize the contraction even at a high concentration of 10-5 M. Norepinephrine, phenylephrine and methoxamine have greater efficacies in the ability to contract than clonidine. R(-) and S(+)-YM 12617 and YM-12617 (pA2 10.4, 8.31 and 9.75, respectively) and prazosin (pA2 8.13), phentolamine (pA2 7.55) and yohimbine (pA2 6.44) competitively an tagonized the contraction elicited by methoxamine. These results suggest that the contraction of rabbit detrusor muscle can be mediated by a1-adrenergic receptors as well as M2-muscarinic and H1-histaminergic receptors and suggest that the contractile force mediated by a, -adrenergic receptor agonist i s smaller than those stimulated by the other receptor agonists.

show abstract

Effects of calcium and verapamil on vesicourethral smooth muscle of rabbits

Cited by 25 publications

References 21 publications

Differing effects of N^G‐monomethyl L‐arginine and 7‐nitroindazole on detrusor activity

Differing effects of N^G‐monomethyl L‐arginine and 7‐nitroindazole on detrusor activity

Effect of Diltiazem on in vitro Rabbit Bladder Function

In vitro characterization of .ALPHA.-adrenergic receptor in rabbit detrusor muscle.

Contact Info

Product

Resources

About

Effects of calcium and verapamil on vesicourethral smooth muscle of rabbits

Cited by 25 publications

References 21 publications

Differing effects of NG‐monomethyl L‐arginine and 7‐nitroindazole on detrusor activity

Differing effects of NG‐monomethyl L‐arginine and 7‐nitroindazole on detrusor activity

Effect of Diltiazem on in vitro Rabbit Bladder Function

In vitro characterization of .ALPHA.-adrenergic receptor in rabbit detrusor muscle.

Contact Info

Product

Resources

About

Differing effects of N^G‐monomethyl L‐arginine and 7‐nitroindazole on detrusor activity

Differing effects of N^G‐monomethyl L‐arginine and 7‐nitroindazole on detrusor activity