Effects of calcium and magnesium-balanced deep sea water on antioxidation in kidney cells

), 조소민 ( So Min Jo; 남자인,; 박건희,; 김병구,; 정귀화,; 허병석,; 김지연,

doi:10.3839/jabc.2021.024

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…Megalin and clathrin are key players in apical endocytosis in PT and reduction of these proteins is related to a reduction in albumin endocytosis 94,95 . Megalin is downregulated with HS diets even in salt insensitive Wistar or SD rats and in the absence of increased urinary albumin excretion 96,97 . However, as discussed earlier, the fact that the expression of transporter genes in the renal cortical proximal tubules appear to be decreased while the expression of genes distal to the TAL is increased suggests that proteolysis may be shifted to the distal tubules.…”

Section: Compensatory Mechanisms To Protect From Hypertension and Kid...mentioning

confidence: 99%

Metabolic responses of normal rat kidneys to a high salt intake

Shimada

Yang

Kurth

et al. 2023

Preprint

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In the present study, novel methods were developed which allowed continuous (24/7) measurement of blood pressure (BP) and renal blood flow (RBF) in freely moving rats and the intermittent collection of arterial and renal venous blood to estimate kidney metabolic fluxes of O2 and metabolites. The study determined the effects of a high salt (HS) diet upon whole kidney O2 consumption and the metabolomic profiles of normal Sprague Dawley (SD) rats. A separate group of rats was studied to determine changes in the cortex (Cx) and outer medulla (OM) tissue metabolomic and mRNAseq profiles before and following the switch from a 0.4% to a 4.0% NaCl diet. Significant changes in the metabolomic and transcriptomic profiles occurred with feeding of the HS diet. A progressive increase of kidney O2 consumption was found despite a reduction in expression of most of the mRNA encoding enzymes of TCA cycle. Increased glycolysis was evident with the elevation of mRNA expression encoding key glycolytic enzymes and release of pyruvate and lactate from the kidney in the renal venous blood. Glycolytic production of NADH is used in either the production of lactate or oxidized via the malate aspartate shuttle. Aerobic glycolysis (e.g., Warburg-effect) may account for the needed increase in cellular energy. The study provides interesting and provocative new data of how normal kidneys respond to a HS diet and guides us toward deeper mechanistic studies examining the effects of a HS diet upon kidney metabolism.

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Section: Compensatory Mechanisms To Protect From Hypertension and Kid...mentioning

confidence: 99%

Metabolic responses of normal rat kidneys to a high salt intake

Shimada

Yang

Kurth

et al. 2023

Preprint

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Effect of Mineral-Balanced Deep-Sea Water on Kidney Function and Renal Oxidative Stress Markers in Rats Fed a High-Salt Diet

Nam

Park

et al. 2021

IJMS

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This study investigated the effect of mineral-balanced deep-sea water (DSW) on kidney health using an animal model of kidney injury due to a high-sodium diet. High magnesium/low sodium (HMLS) and high magnesium/high calcium (HMHC) DSW samples with different mineral contents were prepared. Sprague–Dawley rats were fed an 8% sodium chloride (NaCl) diet for four weeks to induce kidney injury, and each group was supplied with purified water or mineral water. Kidney injury was observed in the NaCl group according to increased kidney injury markers and malondialdehydes, providing evidence of oxidative stress. However, the kidney injury was repaired by the intake of mineral-balanced DSW. It was confirmed that the HMLS and HMHC groups showed improved Na+ excretion through the urine. Kidney injury markers in urine decreased and upregulation of low-density lipoprotein receptor-related protein2 mRNA expression was observed in the HMLS and HMHC groups. In addition, superoxide dismutase activity was increased in the HMHC groups. The gene expression patterns of the RNA sequencing were similar between the CON and HMLS groups. These results suggest that DSW has beneficial effects on kidney health due to the balanced magnesium and calcium levels in models of kidney injury caused by excessive sodium intake.

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Effects of calcium and magnesium-balanced deep sea water on antioxidation in kidney cells

Cited by 2 publications

References 27 publications

Metabolic responses of normal rat kidneys to a high salt intake

Metabolic responses of normal rat kidneys to a high salt intake

Effect of Mineral-Balanced Deep-Sea Water on Kidney Function and Renal Oxidative Stress Markers in Rats Fed a High-Salt Diet

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