Effects of calcitriol on calbindins gene expression and lipid peroxidation in human placenta

Halhali, Ali; Figueras, Ana Guadalupe; Díaz, Lorenza; Avila, Euclides; Barrera, David; Hernández, Guillermo; Larrea, Fernando

doi:10.1016/j.jsbmb.2010.03.008

Cited by 33 publications

(19 citation statements)

References 27 publications

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“…of MDA and ox-LDL. In accordance with our findings, calcitriol at physiological levels had no significant effect on MDA concentrations in cultured syncitiotrophoblast cells (Halhali et al, 2010). We found no significant change in circulating ox-LDL concentrations.…”

Section: Denotes the Significance Of Changes Between Dd And Cdd (One-supporting

confidence: 92%

“…However, based on our findings, the antioxidative action of vitamin D is less effective against lipid peroxidation, as judged by circulating levels of MDA and ox‐LDL. In accordance with our findings, calcitriol at physiological levels had no significant effect on MDA concentrations in cultured syncitiotrophoblast cells (Halhali et al ., ). We found no significant change in circulating ox‐LDL concentrations.…”

Section: Resultsmentioning

confidence: 97%

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Daily intake of vitamin D‐ or calcium‐vitamin D‐fortified Persian yogurt drink (doogh) attenuates diabetes‐induced oxidative stress: evidence for antioxidative properties of vitamin D

Nikooyeh

Neyestani

Tayebinejad

et al. 2013

J Human Nutrition Diet

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Section: Denotes the Significance Of Changes Between Dd And Cdd (One-supporting

confidence: 92%

Section: Resultsmentioning

confidence: 97%

Daily intake of vitamin D‐ or calcium‐vitamin D‐fortified Persian yogurt drink (doogh) attenuates diabetes‐induced oxidative stress: evidence for antioxidative properties of vitamin D

Nikooyeh

Neyestani

Tayebinejad

et al. 2013

J Human Nutrition Diet

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“…Many genes involved in placental Ca transport are known to be up‐regulated by 1,25(OH) 2 D/VDR activity. These include the Ca import protein TRPV6 (18, 38) and the Ca‐chaperone proteins calbindin D9K and D28K (19, 39). 1,25(OH) 2 D treatment of the placental syncytiotrophoblast cell line (JEG‐3) leads to a dose‐dependent increase in Ca uptake (20).…”

Section: Discussionmentioning

confidence: 99%

Placental vitamin D receptor (VDR) expression is related to neonatal vitamin D status, placental calcium transfer, and fetal bone length in pregnant adolescents

et al. 2014

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The purpose of the study was to identify determinants of placental vitamin D receptor (VDR) expression and placental calcium (Ca) transfer among pregnant adolescents. Placental tissue was obtained in 94 adolescents (≤18 yr) at term. In 12 of these teens, stable Ca isotopes were given intravenously ((42)Ca) and orally ((44)Ca) early in labor. Placental VDR expression was assessed via Western blot and validated by RT-PCR. Maternal-to-fetal Ca transfer was calculated as the enrichment in cord blood at delivery relative to maternal serum enrichment 2 h postdosing. Isotopic study outcomes were examined in relation to fetal long bone length, placental VDR, serum 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)2D], and parathyroid hormone (PTH) in maternal circulation and cord blood at delivery. Placental VDR expression was inversely associated with neonatal 25(OH)D (P=0.012) and positively with neonatal 1,25(OH)2D (P=0.006). Placental VDR was a positive predictor of fetal femur length Z score (P=0.018; R(2)=0.06) and was positively correlated with maternal-to-fetal transfer of intravenous (42)Ca (P=0.004; R(2)=0.62). The fetus may regulate placental VDR expression given the significant associations with neonatal vitamin D metabolites. The association between placental VDR and fetal long bone length may indicate a role for VDR in fetal bone development, potentially by mediating transplacental Ca transfer.

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“…20 Calcitriol also stimulates antioxidant gene expression in syncytiotrophoblast cells in a dose response, making it a potential target as a pharmacologic pro-oxidant. 21 The role of vitamin D in decreasing inflammation may be translated to a potential similar role in bladder wall pathophysiology associated with overactive bladder and cystitis.…”

Section: Vitamin D and Obstetric And Other Medical Conditionsmentioning

confidence: 99%

Vitamin D status: a review with implications for the pelvic floor

2012

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Effects of calcitriol on calbindins gene expression and lipid peroxidation in human placenta

Cited by 33 publications

References 27 publications

Daily intake of vitamin D‐ or calcium‐vitamin D‐fortified Persian yogurt drink (doogh) attenuates diabetes‐induced oxidative stress: evidence for antioxidative properties of vitamin D

Daily intake of vitamin D‐ or calcium‐vitamin D‐fortified Persian yogurt drink (doogh) attenuates diabetes‐induced oxidative stress: evidence for antioxidative properties of vitamin D

Placental vitamin D receptor (VDR) expression is related to neonatal vitamin D status, placental calcium transfer, and fetal bone length in pregnant adolescents

Vitamin D status: a review with implications for the pelvic floor

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