Effects of Caffeine and Coffee on Incident Heart Failure in General Population. Role of the CYP1A2 -163C&gt;A Polymorphism

Casíglia, Edoardo; Tikhonoff, Valérie; Albertini, Federica; Montagnana, Martina; Danese, Elisa; Mazza, Alberto; Favaro, Jacopo; Finatti, Francesco; Benati, Marco; Maso, Lorenzo; Gasparotti, Federica; Spinella, Paolo; Palatini, Paolo

doi:10.31871/wjrr.5.1.15

Cited by 3 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present analysis is based on unselected men and women living in an area of about 550 km 2 in northeast Italy and sharing a homogeneous lifestyle, randomly taken from the adult general population in the frame of an epidemiological study whose protocol has been described elsewhere. 11,13 All individuals aged 18 years and over residing in the municipalities of Torrebelvicino and Valli del Pasubio were identified through the register office and were invited by letter and then by phone call to take part in the study, irrespective of any personal characteristic. The 1475 who accepted (73%), aged 60.0 AE 16.7 years (range 19.4-93.9), constituted the population-based cohort object of the present study.…”

Section: General Protocolmentioning

confidence: 99%

“…1 This polymorphism cannot be disregarded, because caffeine effects can be very different in the so-called 'fast metabolisers' (AA homozygous) and 'slow metabolisers' (carrying the C allele). 11,12 This study is aimed at evaluating the effects of caffeine consumption on incident AF in a cohort of unselected men and women from the general population across the -163C > A polymorphism of CYP1A2 gene.…”

Section: Introductionmentioning

confidence: 99%

“…Exploring the effects of caffeine in a series of papers, 11,[14][15][16] we observed an increasing interest about the possible arrhythmogenic action of caffeine. Unfortunately, the studies available in the literature on this topic are limited in number and contradictory Table 1.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Caffeine intake reduces incident atrial fibrillation at a population level

Casíglia

Tikhonoff

Albertini

et al. 2018

Eur J Prev Cardiolog

Self Cite

View full text Add to dashboard Cite

Background The general belief is that caffeine increases the risk of hyperkinetic arrhythmias, including atrial fibrillation. The aim of this study is to investigate the effect of chronic caffeine intake on incident atrial fibrillation in general population. Design and methods A population cohort of 1475 unselected men and women observed for 12 years and left free to intake food or beverages containing caffeine was studied. Subjects were stratified into tertiles of caffeine intake both in the whole cohort and after genotyping for the -163C > A polymorphism of the CYP1A2 gene, regulating caffeine metabolism. Results In the whole cohort, the 12-year incidence of atrial fibrillation was significantly lower in the third (2.2%) than in the first (10.2%) or second (5.7%) tertile of caffeine intake ( P < 0.001). The same trend was observed in all genotypes; the apparently steeper reduction of atrial fibrillation in slow caffeine metabolisers found at univariate analysis was proved wrong by multivariate Cox analysis. Age, chronic pulmonary disease, history of heart failure and of coronary artery disease, and systolic blood pressure - but not the genotype or the caffeine × CYP1A2 interaction term - were significant confounders of the association between incident atrial fibrillation and being in the third tertile of caffeine intake (hazard ratio 0.249, 95% confidence intervals 0.161-0.458, P < 0.01). Conclusions A higher caffeine intake (>165 mmol/day or > 320 mg/day) is associated with a lower incidence of atrial fibrillation in the 12-year epidemiological prospective setting based on the general population.

show abstract

Section: General Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Caffeine intake reduces incident atrial fibrillation at a population level

Casíglia

Tikhonoff

Albertini

et al. 2018

Eur J Prev Cardiolog

Self Cite

View full text Add to dashboard Cite

show abstract

“…[ 49 ] However, in male carriers of the CYP1A2 rs762551 C‐allele, increased consumption of coffee and caffeine was probable with a decreased risk of heart failure. [ 51 ]…”

Section: Resultsmentioning

confidence: 99%

“…Of these, 24 studies were related to cancer ( Table 1 ), [ 17–40 ] and 50 studies to cardiometabolic diseases ( Table 2 ). [ 41–90 ]…”

Section: Methodsmentioning

confidence: 99%

Inter‐Individual Variation in Cancer and Cardiometabolic Health Outcomes in Response to Coffee Consumption: A Critical Review

Visser

Geleijnse

Roos

2020

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope: Coffee is associated with a lower risk of cancer, cardiovascular disease, and type 2 diabetes at the population level. However, individual susceptibility to the effects of coffee consumption will cause heterogeneity in health responses between individuals. In this critical review determinants of inter-individual variability in cancer and cardiometabolic health outcomes in response to coffee and caffeine consumption are systematically evaluated. Methods and results: Embase and MEDLINE are searched for observational studies and clinical trials that examined variation in the response to coffee consumption. A total of 74 studies meet the inclusion criteria, which report variation in cancer (n = 24) and cardiometabolic health (n = 50) outcomes. The qualitative analysis shows that sex, BMI, smoking, alcohol intake, menopausal status, and genetic polymorphisms are probable or possible determinants of inter-individual variability in cancer and cardiometabolic health outcomes in response to coffee and caffeine consumption, albeit the majority of studies have insufficient statistical power to detect significant interaction between these factors and coffee consumption. Conclusion: Several genetic and non-genetic determinants of inter-individual variability in the responses to coffee and caffeine consumption are identified, indicating that some of the health benefits of coffee may only occur in a subgroup of subjects.

show abstract

The impact of genetic variability on the relationship between caffeine and cardiometabolic outcomes: A systematic review

et al. 2023

View full text Add to dashboard Cite

The relationship between caffeine consumption and cardiometabolic health has been reported, however with heterogenous results. Discrepancies in study results may be due to inter‐individual variability between study participants. This systematic review aimed to identify the impact of genetics on the relationship between caffeine consumption and cardiometabolic outcomes. Electronic databases (PubMed and EMBASE) were searched for studies published until July 2021. Selected studies were of both intervention and observational design and included (1) analysis of at least one of the selected cardiometabolic outcome (type 2 diabetes, glucose/insulin levels, cardiovascular disease [CVD], blood pressure [BP] or hypertension, and blood lipid and catecholamine levels), (2) adults aged 18–65 years, and (3) genetic analysis of individuals consuming caffeine. Seventeen studies were included: four randomised controlled trials and an interventional and quasi‐experimental study, six population‐based prospective cohort studies, three cross‐sectional studies, and three case–control studies. CYP1A2 rs762551 and ADORA rs5751876 were associated with glucose response when caffeine was consumed with carbohydrates. CYP1A2 rs762551 moderated the association between coffee intake and hypertension. Moreover, ADORA2A rs5751876 and the ADRA2B I variants moderated the associations between caffeine and BP. Studies that investigated the effects of genetic variations on CVD and caffeine consumption reported equivocal findings (CYP1A2) or warrant replication (COMT, ADORA and TRIB1). Elucidating the extent to which these genes moderate the association between caffeine and cardiometabolic outcomes will enable caffeine consumption advice to be tailored to specific individuals to optimise health.

show abstract

Effects of Caffeine and Coffee on Incident Heart Failure in General Population. Role of the CYP1A2 -163C>A Polymorphism

Cited by 3 publications

References 0 publications

Caffeine intake reduces incident atrial fibrillation at a population level

Caffeine intake reduces incident atrial fibrillation at a population level

Inter‐Individual Variation in Cancer and Cardiometabolic Health Outcomes in Response to Coffee Consumption: A Critical Review

The impact of genetic variability on the relationship between caffeine and cardiometabolic outcomes: A systematic review

Contact Info

Product

Resources

About