Effects of caffeine and chlor-desmethyldiazepam on fighting behavior of mice with different reactivity baselines

Differential effects of ethyl (R,S)-nipecotate on the behaviors of highly and minimally aggressive female golden hamsters

“…However, other behavioral and physiological treatments in this laboratory have been found to suppress aggression in both minimally and highly aggressive animals. A related interpretation is based on analogy to schedule-controlled behaviors: If the number of attacks in 10 min is interpreted as a rate, there is a formal similarity between the present observations and the often reported "rate-sensitivity" of drug effects on these behaviors (cf, Traversa et al 1985). However, the same trend for differential drug effects appeared in locomotor activity in which there were no baseline differences.…”

“…It has recently been reported that a factor which is important in drug effects on aggression in mice is the animal's baseline level of aggressiveness (Traversa et al 1985), Since we have routinely found that hamsters identified as highly or minimally aggressive on initial screening remain so on subsequent tests, our experimental situation lends itself to a test of the cross-species generality of this phenomenon too. A differential response to GABAergic agents would strenghten the hypothesis that differences in GABAergic mechanisms account for the differences between highly and minimally aggressive animals; it would also suggest that a common mechanism underlying both the baseline differences and the differential drug sensitivity could be sought.…”

Caffeinated coffee enhances co-operative behavior in the Mixed Motive Game in healthy volunteers

“…1 Aside from studies on the effects of caffeinated drinks on mood, attention, degree of arousal and anxiety, 2 research that examines the effects of these drinks on social behavior among human beings has received little attention. 3 Empirical findings in animal studies showed that caffeine treatment increased aggressive behavior; 4,5 however, no such enhancement was observed in humans after administration of caffeine. 6 Cherek et al 6 reported that consumption of regular coffee significantly reduced aggressive behavior toward fictitious game partners and increased tendencies towards a behavior that is beneficial for their own monetary gains during a laboratory task.…”