Effects of caffeic acid phenethyl ester and melatonin on distraction osteogenesis: an experimental study

Erdem, Mehmet; Gülabi, Deniz; Şen, Cengiz; Sahin, Seyit Ahmet; Bozdağ, Ergün

doi:10.1186/2193-1801-3-8

Cited by 16 publications

(22 citation statements)

References 28 publications

(45 reference statements)

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“…These effects are likely a result of a reduction in bone resorption due to inhibition of NF-κB and free oxygen radicals. 128 The combination of melatonin and laser irradiation (808 nm, 80 mW, GaAlAs diode) markedly increased the expression of osterix, which promotes the differentiation and mineralization of MC3T3-E1 cells under hypoxic conditions. 129 Additionally, the combination of melatonin, strontium (citrate), vitamin D3, and vitamin K2 induced osteoblastogenesis, increased BMD, and improved quality of life in postmenopausal osteopenic women (ages .…”

Section: Prospects and Conclusionmentioning

confidence: 99%

“…Erdem et al discovered that combined treatment of caffeic acid phenethyl ester (CAPE) and melatonin promotes the maturation of new bone in distraction osteogenesis (Figure ). These effects are likely a result of a reduction in bone resorption due to inhibition of NF‐κB and free oxygen radicals . The combination of melatonin and laser irradiation (808 nm, 80 mW, GaAlAs diode) markedly increased the expression of osterix, which promotes the differentiation and mineralization of MC3T3‐E1 cells under hypoxic conditions .…”

Section: Prospects and Conclusionmentioning

confidence: 99%

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Melatonin: Another avenue for treating osteoporosis?

Tian

Jiang

et al. 2019

Journal of Pineal Research

110

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Melatonin is a signal molecule that modulates the biological circadian rhythms of vertebrates. Melatonin deficiency is thought to be associated with several disorders, including insomnia, cancer, and cardiovascular and neurodegenerative diseases. Accumulating evidence has also indicated that melatonin may be involved in the homeostasis of bone metabolism. Age‐related reductions in melatonin are considered to be critical factors in bone loss and osteoporosis with aging. Thus, serum melatonin levels might serve as a biomarker for the early detection and prevention of osteoporosis. Compared to conventional antiosteoporosis medicines, which primarily inhibit bone loss, melatonin both suppresses bone loss and promotes new bone formation. Mechanistically, by activating melatonin receptor 2 (MT2), melatonin upregulates the gene expression of alkaline phosphatase (ALP), bone morphogenetic protein 2 (BMP2), BMP6, osteocalcin, and osteoprotegerin to promote osteogenesis while inhibiting the receptor activator of NF‐kB ligand (RANKL) pathway to suppress osteolysis. In view of the distinct actions of melatonin on bone metabolism, we hypothesize that melatonin may be a novel remedy for the prevention and clinical treatment of osteoporosis.

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Section: Prospects and Conclusionmentioning

confidence: 99%

Section: Prospects and Conclusionmentioning

confidence: 99%

Melatonin: Another avenue for treating osteoporosis?

Tian

Jiang

et al. 2019

Journal of Pineal Research

110

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“…7,14,15,16,17 Nevertheless, the effects of systemic melatonin application in DO have rarely been studied. 8 The histopathological and immunohistochemical results of this study reveal that melatonin could increase bone formation in mandibular DO in rats. In one in vitro study, Roth et al 17 have reported that melatonin can increase MC3T3-E1 cell differentiation and mineralization.…”

Section: Discussionmentioning

confidence: 59%

“…Likewise, Erdem et al 8 reported in their experimental rat femur DO study that melatonin, caffeic acid, and phenyl ethyl ester all increased the maturation of NBF. They suggested that these effects likely stemmed from reducing the bone tissue's resorptive abilities by inhibiting NF-κβ and free oxygen radicals, as melatonin is known to be a significant free oxygen radical scavenger, and free oxygen radicals disrupt the bone tissue regeneration process.…”

Section: Discussionmentioning

confidence: 84%

Systemic melatonin application increases bone formation in mandibular distraction osteogenesis

et al. 2018

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This study aimed to investigate the effects of different doses of systemic melatonin application on new bone formation during mandibular distraction osteogenesis (DO) in rats. Mandibular DO was performed on 30 adult female Sprague-Dawley rats, which were randomly divided into three groups: control group (CNT), melatonin dose 1 (MLT-D1), and melatonin dose 2 (MLT-D2). A five-day latent waiting period and a ten-day distraction phase followed the surgery. After the surgery, rats from the MLT-D1 and MLT-D2 groups received 25 and 50 mg/kg melatonin, respectively, at 7, 14, 21, 28, and 35 days. The animals were euthanised 28 days after distraction, i.e. at 43 days after surgery. Histological and histomorphometric analyses revealed that the distracted bone area was completely filled with new bone formation in all three groups. The MLT-D2 group exhibited the most new bone formation, followed by MLT-D1 and CNT. The melatonin groups had more osteoclasts than the CNT (p < 0.05). The number of osteoblasts was higher in the melatonin groups than in the CNT group, and the MLT-D2 had more osteoclasts than the MLT-D1 group (p < 0.05). Finally, the osteopontin (OPN) and vascular endothelial growth factor (VEGF) levels were higher in the melatonin groups than in the CNT group, and the MLT-D2 had higher OPN and VEGF levels than the MLT-D1 (p < 0.05). This study suggests that systemic melatonin application could increase new bone formation in DO.

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“…Erdem and coworkers stated that use of CAPE can enhance the maturation of newly regenerated bone. 25 …”

Section: Discussionmentioning

confidence: 99%

Effects of caffeic acid phenethyl ester on palatal mucosal defects and tooth extraction sockets

Günay¹,

Arpağ²,

Atılgan³

et al. 2014

DDDT

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AimThe purpose of this study was to evaluate the effects of caffeic acid phenethyl ester (CAPE) on palatal mucosal defects and tooth extraction sockets in an experimental model.Materials and methodsForty-two male Sprague-Dawley rats with a mean age of 7 weeks and weighing 280–490 g were used in this study. The rats were randomly divided into two groups: group A (the control group, n=21) and group B (the experimental group, n=21). Under anesthesia with ketamine (8 mg/100 g, intraperitoneally), palatal mucosal defects were created and tooth extraction was performed in the rats in groups A and B. Group A received no treatment, whereas group B received CAPE. CAPE was injected daily (10 μmol/kg, intraperitoneally). The rats were killed on days 7, 14, and 30 after the procedures. Palatal mucosa healing and changes in bone tissue and fibrous tissue were evaluated histopathologically.ResultPairwise comparisons showed no statistically significant difference between days 7 and 14 in either group (P>0.05). At day 30, bone healing was significantly better in group B (CAPE) than in group A (control) (P<0.05). Fibrinogen levels at day 30 were significantly higher in group A (control) than in group B (CAPE) (P<0.05). Pairwise comparisons showed no statistically significant difference in palatal mucosa healing levels between days 7 and 14 in both groups (P>0.05).ConclusionIn conclusion, the findings of this study suggest that CAPE can significantly improve tooth socket healing.

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Effects of caffeic acid phenethyl ester and melatonin on distraction osteogenesis: an experimental study

Cited by 16 publications

References 28 publications

Melatonin: Another avenue for treating osteoporosis?

Melatonin: Another avenue for treating osteoporosis?

Systemic melatonin application increases bone formation in mandibular distraction osteogenesis

Effects of caffeic acid phenethyl ester on palatal mucosal defects and tooth extraction sockets

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