Effects of cadmium on the function and structure of the rat salivary glands

Chiarenza, A.P.; Elverdín, Juan C.; Espinal, E G; Giglio, M.J.

doi:10.1016/0003-9969(89)90059-9

Cited by 10 publications

(9 citation statements)

References 11 publications

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“…This process has been described as apoptosis in a number of tissues and the apoptotic bodied which are found in small numbers in normal tissues are greatly increased in tissues which have been subjected to chemotherapy. So ,in this study the salivary gland cells affected by 6MP were underwent either cell death or injury which causes damage (5,9,23) . Other possible mechanism of these changes in salivary glands was injury of the gland cells and to epithelium of salivary gland ducts which is associated with inflammation and fibrosis with raised possibility of autoimmune response (17,24) .…”

Section: Discussionmentioning

confidence: 95%

Effects of 6– Mercaptopurine on Salivary Glands in Rabbit

Al-Moula¹,

Al-Mashhadane²,

Mammdoh³

2012

RDENTJ

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Fayhaa A Al-Mashhadane BDS, MSc (Lec.) Jawna'a K Mammdoh BDS, MSc (Lec.) cavage needle) t ABSTRACT Aims: To study the effect of 6 -Mercaptopurine on salivary glands of rabbits. Materials and Methods:This study was carried out on 6 young rabbits of both sexes, aged 2 -3 months, and weighing 1.250-1.350 Kg. They were divided into control group (4 rabbits) which received no any treatment, and treatment group (4 rabbits) that were treated by 6 -MP in dose of 9 mg/Kg for duration of 2 weeks,the drug was administered orally by cavage needle. All animals were dissected and salivary glands (parotid and submandibular glands) were removed from right and left sides, then slides were made and morphometric analysis were made using filar micrometer, a photographs were done and ttest analysis was used to compare two groups. Results: There was loss of architecture of both parotid and submandibular salivary glands with disarrangement of acini. Acinar cells become smaller in diameter that was associated with increase in the interstitial spaces. There was atrophy and shrinkage of striated ducts and all these changes were significant compared to control group except that for parotid gland which showed no significant differences in height of intercalated duct cells compared to control group. Conclusions: Daily administrations of 6 MP for rabbits produced severe degenerative changes in the salivary glands.

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Section: Discussionmentioning

confidence: 95%

Effects of 6– Mercaptopurine on Salivary Glands in Rabbit

Al-Moula¹,

Al-Mashhadane²,

Mammdoh³

2012

RDENTJ

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“…La densidad volumétrica del parénquima glandular era menor, con mayor proporción de estroma. Estas alteraciones confirman la literatura, señalando alteraciones de la glándula submandibular causadas por el Cd (Chiarenza et al, 1989;Pinto et al, 1998;Paula Lopes et al, 1999;Braga et al, 2001).…”

Section: Discussionunclassified

“…El volumen relativo del estroma era mayor que el del parénquima. Estos hallazgos coinciden con los de Chiarenza et al (1989) que relataron en la parótida, adenómeros menores y conductos con retención de secreción, áreas hemorrágicas, edema e infiltrado inflamatorio.…”

Section: Discussionunclassified

Efectos del Cadmio Sobre las Glándulas Salivales de Rata, Durante la Lactancia

et al. 2009

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“…Subcutaneous administration of cadmium to rats produced histologic signs of tubular and acinar damage in salivary glands. Furthermore, cadmium exposure depressed salivary secretions and reduced the concentration of the major salivary digestive enzyme, amylase, in parotid gland saliva (Chiarenza et al 1989). It has been suggested that these effects of cadmium may be attributable to the inhibition of acetylcholine release and the disruption of parasympathetic impulses, which play a major role in regulating salivary secretions (Cooper and Manalis 1983).…”

Section: Discussionmentioning

confidence: 99%

“…Shearer et al (1980a) showed that exposure to cadmium in rats during the neonatal period resulted in the development of severe dental caries, and this caries-promoting effect of cadmium was not negated by the addition of fluoride to drinking water. Administration of cadmium also disrupted salivary gland function in rats (Abdollahi et al 2000; Chiarenza et al 1989). …”

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confidence: 99%

Association of Environmental Cadmium Exposure with Pediatric Dental Caries

Arora

Weuve²,

Schwartz

et al. 2008

Environ Health Perspect

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BackgroundAlthough animal experiments have shown that cadmium exposure results in severe dental caries, limited epidemiologic data are available on this issue.ObjectivesWe aimed to examine the relationship between environmental cadmium exposure and dental caries in children 6–12 years of age.MethodsWe analyzed cross-sectional data, including urine cadmium concentrations and counts of decayed or filled tooth surfaces, from the Third National Health and Nutrition Examination Survey. We used logistic and zero-inflated negative binomial (ZINB) regression to estimate the association between urine cadmium concentrations and caries experience, adjusting these analyses for potential confounders including environmental tobacco smoke (ETS).ResultsUrine cadmium concentrations ranged from 0.01 to 3.38 ng/mL. Approximately 56% of children had experienced caries in their deciduous teeth, and almost 30% had been affected by caries in their permanent dentition. An interquartile range (IQR) increase in creatinine-corrected cadmium concentrations (0.21 μg/g creatinine) corresponded to a 16% increase in the odds of having experienced caries in deciduous teeth [prevalence odds ratio (OR) = 1.16; 95% confidence interval (CI), 0.96–1.40]. This association was statistically significant in children with low ETS exposure (prevalence OR = 1.30; 95% CI, 1.01–1.67). The results from the ZINB regression indicated that, among children with any caries history in their deciduous teeth, an IQR increase in cadmium was associated with 17% increase in the number of decayed or filled surfaces. We observed no association between cadmium and caries experience in permanent teeth.ConclusionsEnvironmental cadmium exposure may be associated with increased risk of dental caries in deciduous teeth of children.

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Effects of cadmium on the function and structure of the rat salivary glands

Cited by 10 publications

References 11 publications

Effects of 6– Mercaptopurine on Salivary Glands in Rabbit

Effects of 6– Mercaptopurine on Salivary Glands in Rabbit

Efectos del Cadmio Sobre las Glándulas Salivales de Rata, Durante la Lactancia

Association of Environmental Cadmium Exposure with Pediatric Dental Caries

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