Effects of Cadmium on Liver Function and its Metabolomics Profile in the Guizhou Black Goat

Li, Yuanfeng; Shen, Xiaoyun

doi:10.3390/metabo13020268

Cited by 9 publications

(6 citation statements)

References 30 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the literature, Cd is a non-essential element of plants and enters into their roots through the absorption channels of Ca, Fe, Mn, Zn, and other essential elements [27]. For Cd-contaminated soil, the toxic effects of Cd on crops can be alleviated to a certain extent by applying a certain amount of exogenous substances (such as Ca, Fe, Zn, Mn, Mg, and other elements) to the contaminated soil [28][29][30]. Because the above elements and Cd have similar ionic radii and chemical properties, they can share many transport proteins, ion transport channels, and binding sites in crop roots, thereby inhibiting the accumulation and transport of Cd in crops [30].…”

Section: Effectiveness Of CD Removal From Paddy Soilmentioning

confidence: 99%

“…For Cd-contaminated soil, the toxic effects of Cd on crops can be alleviated to a certain extent by applying a certain amount of exogenous substances (such as Ca, Fe, Zn, Mn, Mg, and other elements) to the contaminated soil [28][29][30]. Because the above elements and Cd have similar ionic radii and chemical properties, they can share many transport proteins, ion transport channels, and binding sites in crop roots, thereby inhibiting the accumulation and transport of Cd in crops [30]. Therefore, it can be preliminarily speculated that under the application of GT, the migration and enrichment of Ca, Fe, Mn, Zn, and other metal elements in the soil inhibited the absorption of Cd by rice plants (especially in the roots), which resulted in the insignificant reduction of soil Cd content in the T2 experiment group.…”

Section: Effectiveness Of CD Removal From Paddy Soilmentioning

confidence: 99%

See 1 more Smart Citation

Removal of Heavy Metal Cd Element from Paddy Soil by Geo-Electrochemical Technology

Sun,

Wen,

Liu

et al. 2023

Applied Sciences

View full text Add to dashboard Cite

A Cd-contaminated paddy field at the Quanzhou County Institute of Agricultural Science in Guilin was selected as the research object, and geo-electrochemical technology (GT) was used to treat the Cd-contaminated paddy field in situ. The technology’s effectiveness in removing the heavy metal Cd element from paddy soil and the change rule of Cd accumulation and transport in various parts of rice plants under the action of an electric field were studied. That was to provide a theoretical basis and a new technical choice for remediating paddy soil polluted by Cd. The results showed that the GT effectively removed the heavy metal Cd element from the paddy soil. When the level of soil Cd in the paddy field was 0.58 mg/kg, after in situ treatment with the GT, the soil Cd decreased to 0.39 mg/kg, which met the requirements of soil contamination risk control for agricultural land. Geo-electrochemical technology effectively reduced the content of the Cd element in various tissues and organs of rice plants, made the Cd content in brown rice lower than the requirement of the national food pollutant limit standard of 0.2 mg/kg, and achieved the production of safe rice. Geo-electrochemical technology reduced the enrichment of Cd in the tissues and organs of the rice plants, including roots, stems, leaves, and grains, and at the same time affected the process of rice roots transporting Cd.

show abstract

Section: Effectiveness Of CD Removal From Paddy Soilmentioning

confidence: 99%

Section: Effectiveness Of CD Removal From Paddy Soilmentioning

confidence: 99%

Removal of Heavy Metal Cd Element from Paddy Soil by Geo-Electrochemical Technology

Sun,

Wen,

Liu

et al. 2023

Applied Sciences

View full text Add to dashboard Cite

show abstract

“…The feed formula was displayed in Table 1. [22], CdCl 2 (20 mg Cd•kg −1 •BW) was provided in the drinking water of goats in the Cd group, as described in the study of Li et al (2023) [23].…”

Section: Animal Management and Sample Preparationmentioning

confidence: 99%

“…Metabolites were confirmed using LS-MS/MS analysis. The analysis software (Compound Discoverer version 3.0, STRING software, et al), databases (GO, KEGG, and HMDB), and the detailed parameters were described in previous studies [23]. The p-value for differentially abundant proteins (DAPs) was calculated using the t-test.…”

Section: Identification and Bioinformatics Analysis Of Metabolites An...mentioning

confidence: 99%

Cadmium Exposure Affects Serum Metabolites and Proteins in the Male Guizhou Black Goat

Li,

Shen

2023

Animals

Self Cite

View full text Add to dashboard Cite

Food safety and environmental pollution are the hotspots of general concern globally. Notably, long-term accumulation of trace toxic heavy metals, such as cadmium (Cd), in animals may endanger human health via the food chain. The mechanism of Cd toxicity in the goat, a popular farmed animal, has not been extensively investigated to date. Therefore, in this study, ten male goats (Nubian black goat × native black goat) were exposed to Cd via drinking water containing CdCl2 (20 mg Cd·kg−1·BW) for 30 days (five male goats per group). In this study, we used an integrated approach combining proteomics and metabolomics to profile proteins and metabolites in the serum of Cd-exposed goats. It was found that Cd exposure impacted the levels of 30 serum metabolites and 108 proteins. The combined proteomic and metabolomic analysis revealed that Cd exposure affected arginine and proline metabolism, beta-alanine metabolism, and glutathione metabolism. Further, antioxidant capacity in the serum of goats exposed to Cd was reduced. We identified CKM and spermidine as potential protein and metabolic markers, respectively, of early Cd toxicity in the goat. This study details approaches for the early diagnosis and prevention of Cd-poisoned goats.

show abstract

“…Heavy metals, particularly, Lead and cadmium have a major impact on kidney function, though, lead is thought to have a more pronounced effect on kidney function than cadmium (Haneef et al, 1998). Oral administration of cadmium was shown to intervene with hepatic metabolism by reducing the liver immune function and consequently triggering hepatic damage (Li and Shen, 2023). Cadmium can accumulate in the liver and kidneys over a long period of time (McLaughlin et al, 1999) and interact with several minerals, including zinc, iron and copper, due to its chemical similarities and competition for binding sites which can affect the body's ability to absorb and utilize these essential minerals, leading to negative health effects (Liman et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Lead and Cadmium have an impact on Oxidative Stress, Rumen and Blood Serum Constituents in Grazing Nubian Goats

Oraby,

Baraka,

Salem

et al. 2023

Preprint

View full text Add to dashboard Cite

Environmental pollution, especially water pollution with heavy metals has a direct economic and health impact on the animal industry. This study investigated the impact of water pollution with heavy metals on grazing goats’ haemato-biochemical and oxidative stress parameters, as well as rumen function. Fifty Egyptian Nubian goats were divided into two groups: a control group (n = 13) raised indoors on clean tap water and an exposed group (n = 37) drinking from a polluted drainage water canal with cadmium (Cd) and Lead (Pb). The exposed goats showed significant reductions in RBCs, PCV, Hb, TLC, TP, albumin, globulin, Ca, and P, and significant elevations in MDA. Significant elevation in rumen pH in exposed goats compared to control goat was recorded. Significant reductions in TVFA, ammonia, AST, ALT, GGT, Ca and P were observed in exposed goats compared with the control goats. Positive correlation between Cd/Pb and rumen pH was recorded, while negative correlation was found in association with TVFA, Ammonia, AST, ALT, GGT, Ca and P. Pb and Cd levels were significantly elevated in the rumen and blood of exposed goats compared to control goats. The study concluded that goats watered in polluted areas suffered from alterations in hematological, serum biochemical, rumen fluid constituents, oxidative stress, and disturbance in mineral levels. These results highlight the harmful impact of heavy metals, particularly lead and cadmium, on goat’s health status and body function.

show abstract

Effects of Cadmium on Liver Function and its Metabolomics Profile in the Guizhou Black Goat

Cited by 9 publications

References 30 publications

Removal of Heavy Metal Cd Element from Paddy Soil by Geo-Electrochemical Technology

Removal of Heavy Metal Cd Element from Paddy Soil by Geo-Electrochemical Technology

Cadmium Exposure Affects Serum Metabolites and Proteins in the Male Guizhou Black Goat

Lead and Cadmium have an impact on Oxidative Stress, Rumen and Blood Serum Constituents in Grazing Nubian Goats

Contact Info

Product

Resources

About