Effects of cadmium chloride and biofertilizer (Bacilar) on biochemical parameters of freshwater fish, Alburnus mossulensis

Banaee, Mahdi; Beitsayah, Amal; Prokić, Marko D.; Petrović, Tamara G.; Zeidi, Amir; Faggio, Caterina

doi:10.1016/j.cbpc.2023.109614

Cited by 12 publications

(11 citation statements)

References 51 publications

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“…To our knowledge, this study is the first to investigate the connections between the stress responses and microplastics in C. guichenoti . The selected enzymes in this study are commonly recognized as indicators of stress [ 54 , 55 , 56 , 57 , 58 ], effectively demonstrating the stress response of C. guichenoti after being exposed to microplastics.…”

Section: Discussionmentioning

confidence: 94%

Enzymatic Stress Responses of Coreius guichenoti to Microplastics with Different Particle Sizes

Wu,

Qiu,

Lin

et al. 2023

Toxics

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The wild population resources of Coreius guichenoti have sharply declined in recent decades, and any negative factors may have a significant impact on their survival. In this study, the enzymatic stress responses of C. guichenoti to 25 and 48 μm polyethylene fragments were explored for the first time. This was achieved by evaluating the changes in physiological and biochemical indicators of the species in response to the environmental stimuli of microplastics. In this study, we observed an early stress response in the external tissues of C. guichenoti following exposure to microplastics. The TP content in skin and muscle and the MDA content in skin, gill and muscle initially showed a significant increase. The skin, gill, and muscle exhibited greater stress responses to M5 particles, whereas M3 particles caused a greater response in the intestine and especially the liver. After the removal of microplastic exposure, the stress state of the C. guichenoti would be alleviated in a short period, but it could not fully recover to the pre-exposure level. In summary, microplastics pose a significant threat to C. guichenoti. While their negative effects can be alleviated by the removal of microplastics exposure, full recovery does not occur in a short period. Continuous monitoring of microplastics in natural waters and targeted aquatic ecological restoration are essential to ensure the normal growth and reproduction of the wild population of C. guichenoti.

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Section: Discussionmentioning

confidence: 94%

Enzymatic Stress Responses of Coreius guichenoti to Microplastics with Different Particle Sizes

Wu,

Qiu,

Lin

et al. 2023

Toxics

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“…However, TFN upregulated the mRNA expression of these key genes that regulate glucose and insulin homeostasis. mRNA expression of lactate dehydrogenase (LDH) was upregulated in the CdCl 2 group, resulting in oxidative stress, as reported in recent work . However, TEE treatment mitigated the expression of LDH.…”

Section: Discussionmentioning

confidence: 99%

“…mRNA expression of lactate dehydrogenase (LDH) was upregulated in the CdCl 2 group, resulting in oxidative stress, as reported in recent work. 43 However, TEE treatment mitigated the expression of LDH. CdCl 2 treatment upregulated the expression of angiotensin II receptors, leading to insulin insensitivity, impaired glucose transport in skeletal muscles, and abnormal pancreatic blood flow, which can result in the development of diabetes.…”

Section: ■ Discussionmentioning

confidence: 99%

Modulation of Metabolic Pathways and Protection against Cadmium-Induced Disruptions with Taxifolin-Enriched Extract

Khalid,

Akash,

Rehman

et al. 2024

ACS Omega

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Cadmium, a ubiquitous environmental pollutant, has been implicated in the disruption of various metabolic pathways, contributing to the development of insulin resistance, glucose intolerance, and associated metabolic disorders. This study aimed to investigate the cadmium chloride (CdCl 2 ) exposure on metabolic pathways and to assess the potential therapeutic efficacy of the taxifolin-enriched extract in mitigating these disruptions by modulating biochemical pathways. Taxifolin-enriched extract (TEE) was prepared from Pinus roxburghii bark using a green extraction method. About 60 Wistar albino rats were divided into six groups: the control group (n = 10), the CdCl 2 group (30 mg/kg) (n = 10), and four groups (each comprises n = 10) treated with 30 mg/kg CdCl 2 in combination with metformin (100 mg/kg), ascorbic acid, taxifolin (30 mg/kg), and TEE (30 mg/kg), respectively. After the treatment period of 1 month, a comprehensive assessment of metabolic biomarkers and gene expressions that regulate the metabolism of carbohydrates and lipids was conducted to evaluate the impact of CdCl 2 exposure and the potential protective effects of TEE. The results revealed that CdCl 2 exposure significantly increased (P < 0.001) serum levels of α-glucosidase, α-amylase, insulin, G6PC, hexokinases, TGs, LDL, HMG-CoA reductase, and pro-inflammatory cytokines such as IL-6 and TNF-α. Conversely, CdCl 2 exposure led to a reduction in HDL, antioxidant enzyme levels, phosphofructokinases, and glucose-6-phosphatase dehydrogenase. However, the administration of TEE alongside CdCl 2 substantially mitigated (P < 0.001) these fluctuations in metabolic and inflammatory biomarker levels induced by CdCl 2 exposure. Both TEE and taxifolin treatment effectively lowered the elevated levels of α-amylase, α-glucosidase, G6PC, insulin, TGs, HMG-CoA reductase, leptin, ALT, AST, blood urea nitrogen, creatinine, and pro-inflammatory cytokines while simultaneously enhancing levels of HDL cholesterol and antioxidant enzymes. Moreover, CdCl 2 exposure suppressed mRNA expression of critical metabolic biomarkers such as glucose transporter 2 (GLUT2), insulin-like growth factor 1 (IGF-1), lactate dehydrogenase, and HMG-CoA lyases while upregulating the mRNA expression of angiotensin receptor 2 and vasopressin, key metabolic biomarkers involved in glucose metabolism and insulin regulation. TEE demonstrated the potential to restore normal metabolic functions and reduce the adverse impacts caused by CdCl 2 exposure by mitigating disturbances in several metabolic pathways and restoring gene expression of critical metabolic biomarkers related to glucose metabolism and insulin regulation. Nevertheless, further investigation is warranted to comprehensively understand the underlying mechanisms and optimize the appropriate dosage and duration of TEE treatment for achieving the most effective therapeutic outcomes.

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“…Haematological parameters serve as highly effective indicators, offering valuable insights into fish health and enabling a comprehensive understanding of their homeostasis. This understanding, in turn, can significantly aid in the monitoring of pathophysiological changes related to factors such as nutrition, water quality, or disease, making it a pivotal tool in biomonitoring efforts [ 88 , 89 ]. Findings showed decreased TEC and Hb levels.…”

Section: Discussionmentioning

confidence: 99%

Mitigation of haemato-genotoxic and stress response effects in Cyprinus carpio via silymarin dietary supplementation following deltamethrin exposure

Jindal,

Sharma,

Kaur

et al. 2024

Heliyon

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Effects of cadmium chloride and biofertilizer (Bacilar) on biochemical parameters of freshwater fish, Alburnus mossulensis

Cited by 12 publications

References 51 publications

Enzymatic Stress Responses of Coreius guichenoti to Microplastics with Different Particle Sizes

Enzymatic Stress Responses of Coreius guichenoti to Microplastics with Different Particle Sizes

Modulation of Metabolic Pathways and Protection against Cadmium-Induced Disruptions with Taxifolin-Enriched Extract

Mitigation of haemato-genotoxic and stress response effects in Cyprinus carpio via silymarin dietary supplementation following deltamethrin exposure

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