Effects of cadmium and zinc ions on mice brain lipid peroxidation and amounts of thiol-rich compounds

Enhanced Zinc Intake Protects against Oxidative Stress and Its Consequences in the Brain: A Study in an In Vivo Rat Model of Cadmium Exposure

“…Available data, including the findings of our studies, indicate many beneficial effects of Zn administration also in the alleviation of toxicity of heavy metals, including cadmium (Cd) [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Chronic exposure to Cd of the general population is a global health concern and, despite numerous efforts to restrict its release into the environment, prognoses suggest that human’s intoxication with this toxic element will elevate because it does not undergo biodegradation [ 23 ].…”

“…Recently growing attention has been focused on Cd as a risk factor for neurodegenerative diseases [ 30 , 31 , 32 , 33 ]. Although so far the unfavorable influence of Cd on the nervous system has been revealed in only a few epidemiological studies [ 29 , 30 , 31 ], this effect has been reported in some investigations carried out in animal models [ 18 , 22 , 31 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. The injurious action of this heavy metal on the central nervous system is multidirectional and complex [ 18 , 22 , 31 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ].…”

“…Although so far the unfavorable influence of Cd on the nervous system has been revealed in only a few epidemiological studies [ 29 , 30 , 31 ], this effect has been reported in some investigations carried out in animal models [ 18 , 22 , 31 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. The injurious action of this heavy metal on the central nervous system is multidirectional and complex [ 18 , 22 , 31 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. Literature data indicate that Cd may stimulate the generation of reactive oxygen species (ROS) leading to oxidative stress and interact with essential elements (including calcium—Ca) in the nervous tissue, as well as impair neurogenesis, induce apoptosis of neurons, and influence the glutamatergic system, gene expression, and homeostasis of neurotransmitters, including acetylcholinesterase [ 18 , 22 , 31 , 34 , 35 , 36 , 37 , 38 , 39 , 40 …”

The Effects of Buckwheat Leaf and Flower Extracts on Antioxidant Status in Mouse Organs

“…GSH content was evaluated using the method described by Bernotiene et al [ 15 ]. The removed mouse brain/liver was weighed and homogenized in 6 volumes (as compared with tissue weight) of 5% trichloroacetic acid solution.…”

“…The final product of lipid peroxidation, MDA, forms a complex with TBA (thiobarbituric acid), and the content of it can be determined spectrophotometrically; the results are expressed as nmol/g of the wet weight of the tissue [ 15 ]. The brain/liver was removed and homogenized with 9 volumes (as compared with tissue weight) of cold 1.15% KCl to make 10% homogenate.…”