Effects of cadmium and zinc ions on purified lamb kidney cortex glucose-6-phosphate dehydrogenase activity

Tandogan, Berivan; Ulusu, Nuriye Nuray

doi:10.1080/14756360500480533

Cited by 12 publications

(7 citation statements)

References 44 publications

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“…Understanding the mechanism of inhibition is necessary in order to know how to regenerate the activity of the inhibited enzyme. In general, in the case of metal cations, the interaction mechanism is not completely known, but the action revealed by different metals on the activity of oxidases and dehydrogenases is usually by binding of the metal salts to the thiol groups of the proteins [26][27][28]. The affinity of Pb 2+ and Cd 2+ for SH groups and of Zn 2+ for carboxyl groups has already been reported [29].…”

Section: Repeatability Reproducibility and Stability Of The Biosensormentioning

confidence: 99%

Glucose oxidase inhibition in poly(neutral red) mediated enzyme biosensors for heavy metal determination

Ghica

Brett

2008

Microchim Acta

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A biosensor for the determination of heavy metal cations based on glucose oxidase enzymatic inhibition has been developed. The biosensor was assembled on carbon film electrode supports with glucose oxidase immobilised by cross-linking with glutaraldehyde on top of a film of poly(neutral red) as redox mediator, prepared by electropolymerisation. The biosensor was used to determine the metallic cations, cadmium, copper, lead and zinc in the presence of chosen amounts of glucose. The detection limits were found to be 1 μg L −1 for cadmium, 6 μg L −1 for copper, 3 μg L −1 for lead and 9 μg L −1 for zinc. Inhibition constants were determined by using the Dixon plot, and the type of inhibition induced by the metallic cations was evaluated from Cornish-Bowden plots plus Dixon plots, it being found that the inhibition is reversible and competitive for cadmium, mixed for copper and lead and uncompetitive for zinc. Copper-inhibited glucose oxidase to a greater extent followed by cadmium, lead and zinc. Regeneration of the glucose oxidase response was studied by using Ethylene diamine tetracetic acid metal-chelating agent and the nonionic surfactant Triton X-100. The suitability of the biosensor for determination in foodstuffs or beverages which contain trace concentrations of metals was investigated by performing recovery tests in commercial milk samples.

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Section: Repeatability Reproducibility and Stability Of The Biosensormentioning

confidence: 99%

Glucose oxidase inhibition in poly(neutral red) mediated enzyme biosensors for heavy metal determination

Ghica

Brett

2008

Microchim Acta

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“…Treatment with zinc and H 2 O 2 at the same time has caused higher H 2 O 2 toxicity than H 2 O 2 alone, suggesting that zinc is a direct pro-oxidant in combination with H 2 O 2 in vitro [64]. High zinc doses may be harmful on human health, because zinc can generate methemoglobin increase and oxidative stress via free radical in normal human erythrocytes, impaired immune and inflammatory responses (following an excess dose of 300 mg/day) and copper deficiency-related hemolytic anemia, because zinc may impair gastrointestinal copper absorption and inhibits G6PD activity, as observed in in vitro studies, leading to oxidative damage and consequent hemolytic anemia in G6PD deficient people [65].…”

Section: Mineralsmentioning

confidence: 99%

COVID-19 Drugs and Glucose-6-phosphate Dehydrogenase Deficiency: A Matter of Life Threatening And Public Health

Ioscoa¹,

Eason²,

Gueyec

et al. 2021

ABCMed

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Background: The current COVID-19 pandemic has created significant health consequences for the world population. Therapies and drugs are being continuously developed in an effort to implement the most effective treatment. G6PD deficiency is the most prevalent human enzymatic defect, affecting more than 500 million people worldwide, but is infrequently taken into consideration in healthcare practice. Purpose: The aim of this review is collecting and assembling the most relevant information about safety of current drugs and nutraceuticals, proposed or already used for COVID-19 treatment, with regard to G6PD deficient people, in order to know possible drug-induced adverse effects. Methods: An extensive literature search was performed through scientific papers, unsafe drug lists, drug datasheets, drug databases, National Public Health institutional websites. Results: Methylene blue, ozone, chloroquine and hydroxychloroquine administration should be avoided in G6PD deficient patients. The other reviewed drugs should be administered at therapeutic doses under medical supervision. Conclusion: The list of drugs and nutraceuticals for use in COVID-19 here provided, usefully brought to Healthcare personnel’s and patients’ awareness before any drug administration, may allow you to avoid or at least manage any possible drug-associated symptoms - particularly hemolytic crisis, which is a potentially fatal risk for G6PD deficient patients.

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“…Aluminum also causes encephalopathy, anemia, and bone diseases (21). Heavy metals are generally known as enzyme inhibitors but various heavy metals, including bromine, zinc exist in the polypropylene and are categorized as endocrine disruptors and impairs thyroid hormone metabolism in the organisms (28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). Additionally, zinc and cadmium impair mineral metabolism and parathyroid hormone function leading to the dysfunction in the endocrine metabolism in the organisms (32,41).…”

Section: Surgical Masks and Endocrine Disruptorsmentioning

confidence: 99%

Fate of the face masks in the environment affect human and wildlife: tons of face masks are new source for the endocrine disrupting chemicals

Aydemir

Ulusu

2022

Journal of Basic and Clinical Health Sciences

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COVID-19 pandemic has become a major public health problem affecting the lives of billions of people worldwide. There is an effective vaccine treatment for the coronavirus infection, but self-isolation and selfprotection are the important options to stop the spread of the virus. Usage of the surgical and other face masks are must during COVID-19 pandemic and millions of used masks are accumulating as trash in the environment every day worldwide. Face masks are made of plastic materials mainly polypropylene which is categorized as endocrine disruptor affecting both humans and wildlife. Contamination of face masks to soil, oceans, sea and air may have increased the amount of microplastics concentration and these microplastics from the face masks may have various negative effects on the environment. However, what needs to be done to protect the environment and public health is to dispose of these masks in a very convenient way. Therefore, accurate elimination and collection of used face masks from the environment should be considered to protect our world. Nowadays there are different types of vaccines are in the protecting against death, hospitalization and seriousness of the COVID-19 infection but using face masks are simple, seems safe and effective way from protection against the disease. In this review, we aimed to draw attention to the fact that a using a face mask is very important for staying safe, but they may cause environmental pollution and have adverse effects on directly health and environment.

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Effects of cadmium and zinc ions on purified lamb kidney cortex glucose-6-phosphate dehydrogenase activity

Cited by 12 publications

References 44 publications

Glucose oxidase inhibition in poly(neutral red) mediated enzyme biosensors for heavy metal determination

Glucose oxidase inhibition in poly(neutral red) mediated enzyme biosensors for heavy metal determination

COVID-19 Drugs and Glucose-6-phosphate Dehydrogenase Deficiency: A Matter of Life Threatening And Public Health

Fate of the face masks in the environment affect human and wildlife: tons of face masks are new source for the endocrine disrupting chemicals

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