Effects of cachaça, a typical Brazilian alcoholic beverage, on submandibular glands of rats: a histomorphometric and biochemical study

Prá, Ketelin Juliane Dal; Silva, Aneliza de Fatima Moraes da; Chaves‐Neto, Antônio Hernandes; Soubhia, Ana Maria Pires

doi:10.1007/s00784-020-03290-9

Clin Oral Invest

2020

DOI: 10.1007/s00784-020-03290-9

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Effects of cachaça, a typical Brazilian alcoholic beverage, on submandibular glands of rats: a histomorphometric and biochemical study

Ketelin Juliane Dal Prá

Aneliza de Fatima Moraes da Silva

Antônio Hernandes Chaves‐Neto

et al.

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Cited by 5 publications

References 29 publications

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Reversal of Valproate‐Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats

Cergel,

Tuzuner,

Turkyilmaz

et al. 2024

Chemistry & Biodiversity

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This study aimed to explore the potential protective impacts of Moringa oleifera extract on major alteration in salivary glands of rats exposed to sodium valproate (VA). Groups were defined as control, control + moringa extract, sodium valproate, and sodium valproate + moringa extract. Antioxidant and oxidant status, activities of digestive and metabolic enzymes were examined. VA treatment led to various biochemical changes in the salivary glands, including decreased levels of antioxidants like glutathione, glutathione‐S‐transferase, and superoxide dismutase (except for sublingual superoxide dismutase). Conversely, a decrease in alpha‐amylase, alkaline and acid phosphatase, lactate dehydrogenase, protease, and maltase activities were observed. The study also demonstrated that VA induces oxidative stress, increases lipid peroxidation, sialic acid, and nitric oxide levels in the salivary glands. Total oxidant capacity was raised in all glands except in the sublingual gland. The electrophoretic patterns of proteins were similar. Moringa oleifera extract exhibited protective properties, reversing these VA‐induced biochemical changes due to its antioxidant and therapeutic attributes. This research suggests that moringa extract might serve as an alternative treatment approach for individuals using VA and experiencing salivary gland issues, although further research is necessary to confirm these findings in human subjects.

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Reversal of Valproate‐Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats

Cergel,

Tuzuner,

Turkyilmaz

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

Assessment of redox state and biochemical parameters of salivary glands in rats treated with anti-obesity drug sibutramine hydrochloride

et al. 2022

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The effect of long-term alcohol intoxication on the morphological structures and enzymatic activity of rat salivary glands

Sorkina

Зайцева

Khudyakov

2022

Alcohol

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Effects of cachaça, a typical Brazilian alcoholic beverage, on submandibular glands of rats: a histomorphometric and biochemical study

Cited by 5 publications

References 29 publications

Reversal of Valproate‐Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats

Reversal of Valproate‐Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats

Assessment of redox state and biochemical parameters of salivary glands in rats treated with anti-obesity drug sibutramine hydrochloride

The effect of long-term alcohol intoxication on the morphological structures and enzymatic activity of rat salivary glands

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