Effects of bupropion on simulated demand for cigarettes and the subjective effects of smoking

Madden, Gregory J.; Kalman, David

doi:10.1093/ntr/ntq018

Cited by 103 publications

(54 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although HPTs are becoming increasingly popular in behavioral economic research on addictions (Bickel et al, 2011;Bickel et al, 2014;Jarmolowicz et al, 2016) and behavioral health in general , as of yet only one study has validated the TPT against two commonly used questionnaires in substance use disorder research. Given the growing number of validation studies in the substance use literature (e.g., alcohol and tobacco; Amlung et al, 2012;Amlung & MacKillop, 2014;Amlung et al, 2015;MacKillop et al, 2007;MacKillop & Lisman, 2008;MacKillop et al, 2010;Madden & Kalman, 2010), future research may attempt to validate the TPT with tanning specific addiction tools such as the Structured Interview for Tanning Abuse and Dependence (Hillhouse, Baker, Turrisi, Shields, Stapleton, Jain, & Longacre, 2012), the Tanning Pathology Scale (Heckman et al, 2014;Hillhouse et al, 2010), and experiential tasks.…”

Section: Discussionmentioning

confidence: 99%

An Initial Investigation of the Effects of Tanning-Related Cues on Demand and Craving for Indoor Tanning

2017

View full text Add to dashboard Cite

Melanoma and other skin cancers have become the most commonly diagnosed cancers in the United States. Despite the well-established link between skin cancer and indoor tanning, approximately 30 million Americans report engaging in indoor tanning each year, and the majority of these users are white females aged 16 to 29 years. Although some studies have suggested that exposure to ultraviolet radiation may produce reinforcing effects in frequent tanners paralleling the characteristic features of substance use disorders, no previous study has explored the impact of tanningrelated cues on demand for tanning. The aim of the present study was to examine the effects of tanning-related cues on participants' behavioral economic demand and craving for indoor tanning. Participants were 23 undergraduate students (22 females, one male), each of whom underwent a cueexposure procedure consisting of experiencing neutral-and tanning-related cues. Results suggest that participants exhibited an increase in behavioral economic demand and selfreported craving in the condition associated with tanningrelated cues relative to neutral-cues. We conclude by discussing notable limitations and offering directions for future research.

show abstract

Section: Discussionmentioning

confidence: 99%

An Initial Investigation of the Effects of Tanning-Related Cues on Demand and Craving for Indoor Tanning

2017

View full text Add to dashboard Cite

show abstract

“…The Cigarette Purchase Task (CPT ; MacKillop et al, 2008 ) is based on a model of drug reward assessment that has been successfully used with several drugs including heroin ( Jacobs & Bickel, 1999 ;Petry & Bickel, 1998 ), tobacco ( Jacobs & Bickel, 1999 ;MacKillop et al, 2008 ;Madden & Kalman, 2010 ), and alcohol ( MacKillop et al, 2008 ;Murphy & MacKillop, 2006 ;Murphy, MacKillop, Skidmore, & Pederson, 2009 ). Participants indicated how many cigarettes they would purchase at each of the following 18 prices: 0.01, 0.5, 0.1, 0.3, 0.5, 1,2,3,4,5,6,11,35,70,140,280,560, and 1120 US $ / cigarette.…”

Section: Nicotine and Tobacco Researchmentioning

confidence: 99%

“…Another possible explanation for the CPT results is that the smoker becomes , generally , more sensitive to price for any commodity, which could also be tested by including other choice options besides cigarettes in future studies. Interestingly, a recent study showed that bupropion had no effect on demand elasticity or demand intensity for cigarettes ( Madden & Kalman, 2010 ), which suggests that this effect may be unique to varenicline.…”

Section: Smoking Rewardmentioning

confidence: 99%

Effects of Varenicline on Abstinence and Smoking Reward Following a Programmed Lapse

McClure

Vandrey

Johnson

et al. 2012

Nicotine & Tobacco Research

106

View full text Add to dashboard Cite

Introduction: Varenicline (Chantix®) is an effi cacious fi rstline medication for smoking cessation. Studies suggest that one mechanism by which varenicline facilitates sustained smoking abstinence is by reducing the likelihood of relapse to smoking when a lapse, or slip, occurs during a quit attempt. The present study extends this line of research by conducting a prospective laboratory study to examine the relapse prevention effects of varenicline following a programmed lapse. Methods:Daily smokers ( N = 47) completed a 5-week outpatient study in which they were randomized to receive varenicline or placebo. The fi rst week was a medication induction period that was immediately followed by a 4-week quit attempt. A programmed lapse (2 cigarettes smoked in the laboratory) occurred on the second day of the quit attempt.Results: Participants receiving varenicline were slower to relapse and had greater total abstinence rates following lapse exposure. Participants in the varenicline group rated lapse cigarettes lower on measures of reward and intoxication and showed increased behavioral economic demand elasticity for cigarettes (reduced cigarette purchasing at higher prices) compared with those receiving placebo.Conclusions: These results demonstrate a relapse prevention effect of varenicline following smoking lapse exposure and suggest that an attenuation of reward from smoking and the blunting of subjective effects of smoking may underlie and/or contribute to this effect.

show abstract

“…The CPT has been increasingly used to examine smoking reinforcement (e.g., Bidwell et al, 2012; MacKillop et al, 2008; Madden & Kalman, 2010) to address questions ranging from reliability of the CPT (Few et al, 2011) to evaluating the impact of changes in tobacco control policy (MacKillop et al, 2012; O'Connor et al, 2012). In a recent clinical trial, Madden and Kalman (2010) found that greater increases in elasticity during the week prior to a quit attempt were associated with greater success in quitting.…”

Section: Introductionmentioning

confidence: 99%

“…In a recent clinical trial, Madden and Kalman (2010) found that greater increases in elasticity during the week prior to a quit attempt were associated with greater success in quitting. These data broadly support the predictive validity of the CPT; however, bupropion had no effect on CPT reinforcement parameters.…”

Section: Introductionmentioning

confidence: 99%

The impact of pre-cessation varenicline on behavioral economic indices of smoking reinforcement

Schlienz

Hawk

Tiffany

et al. 2014

Addictive Behaviors

View full text Add to dashboard Cite

Background Varenicline was developed to aid smoking cessation by reducing smoking reinforcement. The present study tests this reinforcement-reduction hypothesis among smokers preparing to quit. Method After a one-week baseline, treatment-seeking smokers were randomized to receive three weeks of varenicline or placebo (Weeks 2-4). During each of the four weeks of the study, smokers completed a hypothetical cigarette purchase task (CPT) via handheld device in their natural environment. Behavioral economic measures of simulated smoking if cigarettes were free (demand intensity), sensitivity of consumption to increasing price (elasticity), and price at which purchases would drop to 0 (breakpoint) were estimated. Results Exponential demand equations fit the purchase task data well across subjects and time. As predicted, demand intensity decreased and sensitivity to price (elasticity) increased over time. However, changes in demand intensity did not differ by treatment group. Contrary to our hypothesis that varenicline would increase sensitivity to price, the placebo group tended to become more elastic in their purchases during Weeks 2 and 3; the groups did not differ in elasticity at Week 4. Breakpoint did not vary by group, time, or their interaction. Conclusion Simulated smoking demand can be validly assessed in the natural environment of treatment-seeking smokers. Simulated demand indices of smoking reinforcement diminished as smokers approached their target quit date. However, there was no evidence that varenicline facilitated these changes over a three week period, leaving open the mechanisms by which varenicline reduces smoking rate prior to cessation and improves long-term abstinence.

show abstract

Effects of bupropion on simulated demand for cigarettes and the subjective effects of smoking

Cited by 103 publications

References 44 publications

An Initial Investigation of the Effects of Tanning-Related Cues on Demand and Craving for Indoor Tanning

An Initial Investigation of the Effects of Tanning-Related Cues on Demand and Craving for Indoor Tanning

Effects of Varenicline on Abstinence and Smoking Reward Following a Programmed Lapse

The impact of pre-cessation varenicline on behavioral economic indices of smoking reinforcement

Contact Info

Product

Resources

About