Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats

Abstract

Little is known about the effects of methamphetamine (Meth) and buprenorphine (Bup) on memory and learning in rats. The aim of this investigation was to examine the impact of Meth and Bup on memory and learning. Fourteen male Wistar rats weighing 250–300 g were assigned to four groups: Sham, Meth, Bup, and Meth + Bup and were treated for 1 week. Spatial learning and memory, avoidance learning, and locomotion were assessed using the Morris water maze, passive avoidance learning, and open field tests, respectively. Meth and Bup impaired spatial learning and memory in rats. Co-administration of Meth + Bup did not increase the time spent in the target quadrant compared to Meth alone in the MWM. The Bup and Meh + Bup groups were found with an increase in step-through latency (STLr) and a decrease in the time spent in the dark compartment (TDC). Meth and Bup had no effects on locomotor activity in the open field test. Bup showed a beneficial effect on aversive memory. Since Bup demonstrates fewer side effects than other opioid drugs, it may be preferable for the treatment of avoidance memory deficits in patients with Meth addiction.

CCL2 is required for initiation but not persistence of HIV infection mediated neurocognitive disease in mice

“…Buprenorphine treatment also reduced HIV burdens and inflammatory monocyte levels in the brain 56 , suggesting that continuing migration of HIV-infected monocytes to the brain is required to maintain HIV-NCI. However, since buprenorphine also affects various aspects of behavior 57 , 58 , additional mechanisms may apply. The ability to reverse NCI is consistent with the state of brain neuropathology in PLWH with mild NCI and in our model of mice with EcoHIV NCI.…”

CCL2 is required for initiation but not persistence of HIV infection mediated neurocognitive disease in mice

“…EcoHIV NCI in mice 54 ; possibly through its action on CCL2 expression 38 . This suggests that buprenorphine reverses NCI through inhibition of monocyte migration, however, buprenorphine also has effects within the brain upon various aspects of behavior 55,56 , so the mechanism of buprenorphine action upon EcoHIV NCI remains under study.…”

Short- and long-term administration of buprenorphine improved gene expression of P2X4 and GABAA receptors in the hippocampus of methamphetamine rats

“…Nevertheless, clinical investigations have also demonstrated a moderate dose METH enhances learning and memory function, including visuospatial perception and response speed [ 49 ]. There are also claims that preadolescent METH exposure improves the spatial learning of male rats [ 50 , 51 ]. Conversely, some studies demonstrated various effects of different doses of METH on the nervous system [ 1 , 52 , 53 , 54 ].…”