Effects of buprenorphine on motor activity of the sphincter of Oddi in man

Cuer, J. C.; Dapoigny, Michel; Ajmi, S.; Larpent, J. L.; Lunaud, B.; Ferrier, Catherine; Bommelaer, Gilles

doi:10.1007/bf00609196

Cited by 32 publications

(15 citation statements)

References 6 publications

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“…meperidine), buprenorphine and tramadol did not stimulate sphincter of Oddi motility in such a profound manner. 8,18,20,21 Furthermore, two recent investigations had found that the synthetic opioid, meperidine, did not alter the sphincter of Oddi baseline pressure, but stimulated the phasic sphincter contraction frequency. 22,23 In contrast to these ®ndings, Staritz et al (by endoscopic manometry) and Tanaka (by post-operative manometry via T-tube) showed that 30 mg of the opioid analgesic pentazocine i.v.…”

Section: Discussionmentioning

confidence: 99%

Tilidine does not affect human sphincter of Oddi motility—a randomized, controlled study

Wehrmann

Rausch

Seiler³

et al. 1997

Aliment Pharmacol Ther

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Aim: To investigate the effects of intravenous pentazocine and tilidine on sphincter of Oddi motility. Methods: Twenty patients with suspected sphincter of Oddi dysfunction were enrolled in a prospective, double‐blind study. Sphincter of Oddi motility was assessed by means of endoscopic manometry after injection of 0.9% saline, as well as after randomized dosing with either 30 mg pentazocine i.v. (n = 10) or 50 mg tilidine i.v. (n = 10). Results: Pentazocine significantly increased the sphincter of Oddi baseline pressure from 32 ± 21 mmHg (saline) to 41 ± 19 mmHg (P = 0.002), whereas tilidine did not alter the sphincter baseline pressure (34 ± 15 mmHg saline vs. 36 ± 16 mmHg tilidine, P = 0.16). Furthermore, pentazocine increased the phasic sphincter contraction amplitude (108 ± 16 mmHg saline vs. 121 ± 18 mmHg pentazocine, P = 0.004), but tilidine was without any effect (125 ± 24 mmHg saline vs. 125 ± 21 mmHg tilidine, P = 0.93). The phasic sphincter of Oddi contraction frequency and duration were not influenced either by pentazocine or by tilidine. Conclusion: In contrast to 30 mg of pentazocine, 50 mg of tilidine does not affect sphincter of Oddi motility. Therefore, tilidine can be used during endoscopic manometry and for analgesia in pancreatobiliary disease.

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Section: Discussionmentioning

confidence: 99%

Tilidine does not affect human sphincter of Oddi motility—a randomized, controlled study

Wehrmann

Rausch

Seiler³

et al. 1997

Aliment Pharmacol Ther

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“…In recent decades, morphine, the 'gold standard' for general pain relief, has been excluded from acute pancreatitis based on indirect findings of spasm in the SO [3,4] . However, in manometric studies only high doses of morphine had been able to significantly increase basal pressure in the SO [8][9][10][11][12][13][14] . In addition, nobody has provided evidence that this possible morphine spasmodic effect on the SO would induce a worse clinical evolution or complications in acute pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

“…However, biochemical and neurological changes can regulate antinociceptive response and modify narcotic adverse event in painfully conditions. When direct measurements of SO dynamics were assessed, the behaviour of morphine was controversial [9][10][11][12][13][14] . In short, there is not enough evidence that supports the contraindication or limitation of morphine for acute pancreatitis pain treatment.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Tolerance of Metamizole versus Morphine for Acute Pancreatitis Pain

Peiró

Martínez

et al. 2008

Pancreatology

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“…Es exis tie ren kei ne Stu di en bei Kin dern oder Er wach se nen, die die Über-le gen heit ei nes be stimm ten Opio ids be legen (Über sicht bei [40]). Tra ma dol scheint den Sphinc ter Oddi zu re la xie ren, und Bup re nor phin scheint kei nen Ein fluss auf den Mus kel to nus des Sphinc ter Oddi zu ha ben [10,36]. Ob die Be ein flus sung des Sphinc ter-Oddi-To nus in ei nem Zu sammen hang mit dem Hei lungs ver lauf ei ner Pank re a ti tis steht, ist völ lig un klar.…”

Section: Pank Re a Ti Tisunclassified

Praktische Schmerztherapie in der pädiatrischen Onkologie

Zernikow

Schießl

Wamsler

et al. 2006

Schmerz

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In pediatric oncology, optimal pain control is still a challenge. A structured pain history and the regular scoring of pain intensity using age-adapted measuring tools are hallmarks of optimal pain control. Psychological measures are as important as drug therapy in the prophylaxis or control of pain, especially when performing invasive procedures. Pain control is oriented toward the WHO multistep therapeutic schedule. On no account should the pediatric patient have to climb up the "analgesic ladder" - strong pain requires the primary use of strong opioids. Give opioids preferably by the oral route and by the clock - short-acting opioids should be used to treat breakthrough pain. Alternatives are i.v. infusion, patient-controlled analgesia, and transdermal applications. Constipation is the adverse effect most often seen with (oral) opioid therapy. Adverse effects should be anticipated, and prophylactic treatment should be given consistently. The assistance of pediatric nurses is of the utmost importance in pediatric pain control. Nurses deliver the basis for rational and effective pain control by scoring pain intensity and documenting drug administration as well as adverse effects. The nurses' task is also to prepare the patient for and monitor the patient during painful procedures. It is the responsibility of both nurse and doctor to guarantee emergency intervention during sedation whenever needed. In our guideline we comment on drug selection and dosage, pain measurement tools, and documentation tools for the purpose of pain control. Those tools may be easily integrated into daily routine.

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Effects of buprenorphine on motor activity of the sphincter of Oddi in man

Cited by 32 publications

References 6 publications

Tilidine does not affect human sphincter of Oddi motility—a randomized, controlled study

Tilidine does not affect human sphincter of Oddi motility—a randomized, controlled study

Efficacy and Tolerance of Metamizole versus Morphine for Acute Pancreatitis Pain

Praktische Schmerztherapie in der pädiatrischen Onkologie

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