Effects of brotizolam on the sleep of chronic insomniacs.

Mamelak, Mortimer; Csima, Adele; Price, Victoria

doi:10.1111/j.1365-2125.1983.tb02313.x

Cited by 8 publications

(1 citation statement)

References 5 publications

(5 reference statements)

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“…However, unlike the case with many short-acting benzodiazepine hypnotics, with drawal insomnia was not found with zopi clone [5,6], This confers an important clini cal advantage on this drug. The effects of zopiclone on sleep morphology were consis tent with its short half-life and were compa rable to those of short-acting benzodiazepine hypnotics [7,8], Zopiclone decreased the du ration of stage 1, increased the duration of stage 2, and slightly, but definitely, decreased the duration of stages 3 and 4. There was no significant effect on REM sleep.…”

Section: Discussionmentioning

confidence: 99%

Effects of Zopiclone on the Sleep of Chronic Insomniacs

1983

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The purpose of this study was to evaluate the short- and intermediate-term (21 days) effectiveness, as well as the carryover and withdrawal effects of 7.5 mg of zopiclone, a new short-acting hypnotic agent. 6 patients with chronic insomnia, ranging in age from 33 to 57, participated in the study. Both EEG sleep recordings and subjective rating scales were used to evaluate the drug. Zopiclone increased the total sleep time throughout its 3-week administration period although only during the short-term period was this increase statistically above baseline. There was no carryover effect nor rebound insomnia upon drug withdrawal. The drug significantly increased the duration of stage 2 sleep, decreased stages 3 and 4 sleep, and had no effect on the duration of REM sleep. There were no reported side effects.

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Section: Discussionmentioning

confidence: 99%

Effects of Zopiclone on the Sleep of Chronic Insomniacs

1983

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Sleep and Psychiatric Disorders

Benca

Obermeyer²,

Thisted³

et al. 1992

Arch Gen Psychiatry

1,352

623

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Alprazolam: Effects on Sleep and Withdrawal Phenomena

Kales

Bixler

Vela‐Bueno

et al. 1987

The Journal of Clinical Pharma

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Alprazolam was evaluated in chronic insomniacs in a 1-mg bedtime dose. The 16-night sleep laboratory protocol included four placebo-baseline nights followed by seven nights of drug administration and five placebo-withdrawal nights. On the first three drug nights (nights 5 to 7), the drug was highly effective in inducing and maintaining sleep with this short-term use. By the end of the one week of administration (nights 9 to 11), however, the drug had lost about 40% of its efficacy. During drug use, one subject reported some difficulty in controlling expression of inappropriate emotions when interacting with others, which suggested the presence of disinhibition. On the third night following drug termination, there was a significant increase in sleep difficulty above baseline levels (rebound insomnia). This worsening was of comparable magnitude to the peak improvement of sleep with drug administration. Thus, the clinical utility of alprazolam when administered to insomniac patients appears to be limited because of a relatively rapid development of tolerance and possible disinhibitory reactions during drug use and the occurrence of rebound insomnia following withdrawal.

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Effects of brotizolam on the sleep of chronic insomniacs.

Cited by 8 publications

References 5 publications

Effects of Zopiclone on the Sleep of Chronic Insomniacs

Effects of Zopiclone on the Sleep of Chronic Insomniacs

Sleep and Psychiatric Disorders

Alprazolam: Effects on Sleep and Withdrawal Phenomena

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