Effects of branched‐chain amino acid‐enriched nutrient for patients with hepatocellular carcinoma following radiofrequency ablation: A one‐year prospective trial

Kuroda, Hidekatsu; Ushio, Akira; Miyamoto, Yukio; Sawara, Kei; Oikawa, Kanta; Kasai, Kazuhiro; Endo, Ryujin; Takikawa, Yasuhiro; Kato, Akinobu; Suzuki, Kazuyuki

doi:10.1111/j.1440-1746.2010.06306.x

Cited by 46 publications

(45 citation statements)

References 28 publications

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“…The effect of BCAAs on HCC recurrence after radiofrequency ablation (RFA) remains unclear. Two prospective studies showed that BCAA supplementation improved nutritional state and liver function, but its effect on HCC recurrence was not determined [78,79] . However, a recent retrospective study showed that oral BCAA supplementation after RFA improved 1 year (61.8% vs 52.0%) and 3-year (28.0% vs 12.0%) progression-free survival rates compared with a control group after RFA (P = 0.013) [80] .…”

Section: Bcaas For Liver Cirrhosismentioning

confidence: 99%

Branched-chain amino acids in liver diseases

Tajiri¹,

Shimizu²

2018

Transl. Gastroenterol. Hepatol.

100

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Branched chain amino acids (BCAAs) have been shown to affect gene expression, protein metabolism, apoptosis and regeneration of hepatocytes, and insulin resistance. They have also been shown to inhibit the proliferation of liver cancer cells in vitro , and are essential for lymphocyte proliferation and dendritic cell maturation. In patients with advanced chronic liver disease, BCAA concentrations are low, whereas the concentrations of aromatic amino acids such as phenylalanine and tyrosine are high, conditions that may be closely associated with hepatic encephalopathy and the prognosis of these patients. Based on these basic observations, patients with advanced chronic liver disease have been treated clinically with BCAA-rich medicines, with positive effects.© 2013 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Liver disease; Branched chain amino acids; Gene expression; Hepatocyte apoptosis; Hepatocyte regeneration; Immunity; Treatment Core tip: Advanced liver diseases are commonly accompanied by nutritional disturbances, which worsen the prognosis of the patients. Serum levels of branchedchain amino acids (BCAAs) are decreased in patients with liver cirrhosis, and the amino acids imbalance could affect the clinical picture of the disease and the prognosis of the patients. However, there are few comprehensive reviews on the biological activities of BCAAs. In this review, we summarize the biological activities of BCAAs, and discuss possible applications of BCAAs for the management of patients with advanced liver diseases with a list of clinical trials of BCAA administration.Tajiri K, Shimizu Y. Branched-chain amino acids in liver diseases. World

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Section: Bcaas For Liver Cirrhosismentioning

confidence: 99%

Branched-chain amino acids in liver diseases

Tajiri¹,

Shimizu²

2018

Transl. Gastroenterol. Hepatol.

100

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“…In general, energy metabolism is evaluated according to the non-protein respiratory quotient (npRQ) based on indirect calorimetry (11)(12)(13). Moreover, recent studies have shown that supplementation with BCAA-enriched nutrients improves the npRQ in HCC patients after RFA (14). However, no studies have examined whether BCAA granule supplementation improves the npRQ in HCC patients after RFA.…”

Section: Introductionmentioning

confidence: 99%

Branched-chain Amino Acid Granules Improve the Non-protein Respiratory Quotient after Radiofrequency Ablation

et al. 2014

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Objective The supplementation of oral branched-chain amino acid (BCAA) granules is known to improve energy metabolism in cirrhotic patients, but not those with hepatocellular carcinoma (HCC). We aimed to clarify whether BCAA granules improve energy metabolism in HCC patients after radiofrequency ablation (RFA). Methods We performed a prospective cohort study (UMIN000004624) involving 40 HCC patients who underwent RFA at Kobe University Hospital. Indirect calorimetry and urinary/blood biochemical examinations were performed before and seven days after RFA. Blood biochemical examinations were also conducted three months after RFA. The patients treated with and without BCAA supplementation were compared, and univariate factors were statistically examined. Results The non-protein respiratory quotient (npRQ) and albumin levels before RFA were significantly lower in the BCAA group than in the control group (p=0.024 and 0.005). The npRQ ratio (seven days after/ before RFA) was significantly higher in the BCAA group than in the control group (p=0.019). In addition, the albumin ratio (three months after/before RFA) was significantly higher in the BCAA group than in the control group (p=0.018). Conclusion Supplementation with BCAA granules improves energy metabolism in addition to the liver function after RFA. Improvements in the liver function may result in consistently adequate treatment for HCC recurrence after RFA.

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“…In these patients with underlying PEM, RFA therapy may further worsen their nutritional condition and even occasionally lead to the development of ascites and jaundice, resulting in an irreversible outcome. [8][9][10] Supplementation with BCAA for the treatment of patients with liver disorder has been attracting attention. BCAA has a variety of pharmacological effects.…”

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confidence: 99%

The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation

Nishikawa

Osaki

Iguchi

et al. 2013

Journal of Clinical Gastroenterology

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Effects of branched‐chain amino acid‐enriched nutrient for patients with hepatocellular carcinoma following radiofrequency ablation: A one‐year prospective trial

Abstract: Supplementation with BCAA-enriched nutrients for one year in cirrhotic patients with HCC after RFA therapy can perform safety and improve both nutritional state and quality of life.

Cited by 46 publications

References 28 publications

Branched-chain amino acids in liver diseases

Branched-chain amino acids in liver diseases

Branched-chain Amino Acid Granules Improve the Non-protein Respiratory Quotient after Radiofrequency Ablation

The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation

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